Abstract：
:The relationship between Ni-induced hepatic lipid peroxidation (LPO) and the concentrations of Ni and trace elements was investigated in male ICR mice. The protective effects of antioxidants were also examined. Hepatic LPO and the concentrations of Ni, Fe, Cu, and Zn in the liver were enhanced after an ip injection of nickel chloride (NiCl2). Dose-response studies were conducted on male mice with different groups being injected with 50, 85, and 170 micromol Ni/kg. LPO increased significantly in a dose-dependent manner. In time-course studies, mice were administrated NiCl2 (170 micromol Ni/kg) and killed at intervals of 6, 12, 24, and 48 h after injection. Both LPO and the accumulation of Ni, Fe, Cu, and Zn in the liver showed a significantly positive time-course relationship after NiCl2 injection. At 1 h and 24 h after a single ip injection of 170 micromol Ni/kg, the mice were given an ip injection of ascorbic acid (vit C), glutathione (GSH), and selenium (Se). Vit C and GSH significantly decreased both the level of hepatic LPO and the concentration of Ni in the liver, but did not decrease the accumulation of Fe, Cu, and Zn. However, LPO in the experimental group of mice was different significantly from that in the control group. In conclusion, the results suggest that Ni-induced hepatic LPO may result from increasing the amounts of Ni, Fe, and Cu, since these elements are involved in the generation of hydroxyl radical by inducing the Fenton reaction, thus instigating the Ni-mediated hepatic LPO. The protective effects of vit C and GSH in hepatic LPO result not only from removing the oxygen reactive species, but also from decreasing the Ni concentration.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Chen CY,Huang YL,Lin THdoi
10.1007/BF02784030subject
Has Abstractpub_date
1998-02-01 00:00:00pages
193-205issue
2eissn
0163-4984issn
1559-0720journal_volume
61pub_type
杂志文章abstract：:Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents with Down syndrome was evaluated by means of biochemical parameters ...
journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
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journal_title：Biological trace element research
pub_type： 杂志文章,meta分析
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-11-01 00:00:00
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更新日期：2012-08-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：1999-11-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783128
更新日期：1998-01-01 00:00:00
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