Abstract：
:Previous studies showed the attenuation of both morphine-dependence and morphine-place preference by zinc. Conditioned place preference and aversion are experimental models frequently used to test the reward-stimulating, respectively the aversive effects induced by different stimuli or substances. Addictive substances usually induce place preference (exhibit reward-stimulating properties), while their antagonists determine place-avoidance (aversion). The present study aimed to assess the effect determined by zinc sulphate oral administration (2 and 4 mg/kg/day, 14 days, prior to habituation) on the place aversion induced by two naloxone doses (1.5 and 2.5 mg/kg/administration). The results show a robust, dose-dependent reduction of the aversion determined by both naloxone doses (the aversion induced by 1.5 mg/kg naloxone was reduced with 15%-the lower zinc dose and with 24%-the higher zinc dose; the aversion induced by 2.5 mg/kg naloxone was reduced with 16%-the lower zinc dose and with 29%-the higher zinc dose). This represents a new proof of the interactions between zinc and opioidergic system and a further argument for dietary zinc supplementation in patients on opioids for cancer-related chronic pain.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Ciubotariu D,Lupușoru RV,Luca E,Mititelu-Tarțău L,Lupușoru CEdoi
10.1007/s12011-017-0995-1subject
Has Abstractpub_date
2017-11-01 00:00:00pages
127-134issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-017-0995-1journal_volume
180pub_type
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