Abstract:
:Suppression subtractive hybridization analysis in our laboratory recently revealed that transferrin mRNA may be elevated in Sedeficient rat liver. In this work, we compared expression in rat liver of genes for transferrin, transferrin receptor, ferritin light and heavy chains, and iron-regulatory proteins 1 and 2 in Se adequacy and deficiency. Weanling male Sprague-Dawley rats were fed Torula yeast diets supplemented with 0 or 0.15 microg Se/kg diet as sodium selenite for 15 wk. Activity of cellular glutathione peroxidase was virtually abolished in Se-deficient rat liver, whereas activity of glutathione S-transferase was 43% higher than in Se-adequate liver. There were no differences in hematocrit, hemoglobin, or liver iron content. To examine differential gene expression, we used a multiplex relative reverse transcriptase-polymerase chain reaction method. Three of the six genes examined showed modest but consistent upregulation in Se deficiency. Transferrin mRNA was 30% more abundant in Se-deficient than in Se-adequate liver. For the transferrin receptor, the difference was 32%, and for iron regulatory protein 1, it was 63%. No consistent differences were observed for iron regulatory protein 2 or for ferritin light or heavy chain. These findings suggest a possible role for dietary Se in moderating iron metabolism.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Christensen MJ,Olsen CA,Hansen DV,Ballif BCdoi
10.1385/BTER:74:1:55subject
Has Abstractpub_date
2000-04-01 00:00:00pages
55-70issue
1eissn
0163-4984issn
1559-0720pii
BTER:74:1:55journal_volume
74pub_type
杂志文章abstract::The new range of sealed-tube neutron generators developed by SODERN appears to be appropriate for the industrial environment. The main characteristics are the high emission stability during the very long lifetime of the tube, flexible pulsed mode capability, safety in operation with no radiation in "off" state, and th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917309
更新日期:1994-10-01 00:00:00
abstract::A semiquantitative ICP-MS method suitable for evaluating metal content in plants exposed to high metal concentrations is described. The methodology which has been tested using different plant reference material is able, in only a few minutes, to obtain qualitative and quantitative information from the sample. Recoveri...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9140-8
更新日期:2011-12-01 00:00:00
abstract::Interactions of clinical laboratory parameters with trace elements in knee-joint effusions might turn out to be potential diagnostic tool, increasing our pathophysiological understanding and knowledge on knee-joint effusions. Thus, the 11 clinical laboratory parameters, total protein, albumin, glucose, lactate dehydro...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:79:2:139
更新日期:2001-02-01 00:00:00
abstract::Zinc, copper, and selenium statuses were reported to be linked to the development of chronic diseases, especially coronary heart disease (CHD). Metabolic syndrome, a known CHD risk factor, was found to be highly prevalent in Lebanon. Nevertheless, no data are available on the statuses of plasma zinc, copper, and selen...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8112-0
更新日期:2008-07-01 00:00:00
abstract::In this study, we evaluated the synergistic effects of genistein and zinc on bone metabolism, bone mineral density, and the femoral metaphyseal histomorphology in the ovariectomized rats. Sixty female Sprague-Dawley rats, aged 13 weeks, were divided into sham-operated group (SHAM), ovariectomized group (OVX), genistei...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1134-8
更新日期:2018-06-01 00:00:00
abstract::In the present study, 15 different commercial tea brands sold in Khyber Pakhtunkhwa were collected from the markets. The samples were analyzed for the concentrations of ten selected heavy metals. The metal concentration showed a random distribution in all samples. The mean concentration of Cd, Cu, Mn, Pb, Zn, and Fe w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02059-1
更新日期:2020-11-01 00:00:00
abstract::The seeds of Nelumbo nucifera (Lotus) have been used in the traditional system of medicine for various ailments including diabetes. The present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hypoglycemic propertie...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8614-4
更新日期:2010-12-01 00:00:00
abstract::The purpose of this study was to assess insoluble salts containing gadolinium (Gd(3+)) for effects on human dermal fibroblasts. Responses to insoluble Gd(3+) salts were compared to responses seen with Gd(3+) solubilized with organic chelators, as in the Gd(3+)-based contrast agents (GBCAs) used for magnetic resonance ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9176-9
更新日期:2012-02-01 00:00:00
abstract::Heavy metals toxicity is a prevalent health problem particularly in developing countries. Mercury and cadmium are toxic elements that have no physiologic functions in human body. They should not be present in the human body by any concentration. Copper, on the other hand, is one of the elements that are essential for ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0525-y
更新日期:2016-06-01 00:00:00
abstract::A cohort study on platers in Tokyo was carried out using the records of the Tokyo Health Insurance Society of Plating Industry. The type of work and chromium-exposure history of each member of this society was investigated by a questionnaire sent to the manager of each factory. The recovery rate of the questionnaire w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783841
更新日期:1979-03-01 00:00:00
abstract::The present study was conducted to assess the influence of dietary zinc nanoparticles (size 50 nm) on the growth, biochemical constituents, enzymatic antioxidant levels and the nonspecific immune response of the freshwater prawn, Macrobrachium rosenbergii post larvae (PL). The concentrations of dietary supplement zinc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0026-4
更新日期:2014-07-01 00:00:00
abstract::Reversed-phase liquid chromatography-inductively coupled plasma mass spectrometric hyphenation was used for iodine speciation in human serum. First investigations showed that iodine species nearly quantitatively were eluted in the void volume. The result indicated that protein-linked thyroid hormones were not interact...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:78:1-3:81
更新日期:2000-01-01 00:00:00
abstract::Diabetic osteoporosis (DOP) is a complication of diabetes, with the characteristics of bone mineral density (BMD) reduction and bone structure destruction. Zinc was reported has a benefit effect on postmenopausal osteoporosise, it was also has hypoglycemic effect, whether zinc was beneficial on diabetes-induced osteop...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01810-7
更新日期:2020-04-01 00:00:00
abstract::It is well known that rare earth elements (REEs) have come into extensive use in a number of fields. As a result, REEs are becoming closely related to human's daily life. However, until now, the distributions of REEs in the brain are not yet very clear. In this study, Sprague-Dawley male rats were intraperitoneally in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:104:1:033
更新日期:2005-04-01 00:00:00
abstract::An increase in hepatic iron concentration might exacerbate liver injury. However, it is unknown whether hepatic iron overload may exacerbate acute liver injury from various toxins. Therefore, we evaluated how manipulations to increase hepatic iron concentration affected the extent of acute liver injury from thioacetam...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0110-9
更新日期:2015-02-01 00:00:00
abstract::Although lead is known to induce arterial hypertension and vascular damage, it is not clear if after cessation of lead treatment, the increase of blood pressure is sustained and the vascular function is different from untreated rats. Therefore, we aimed to evaluate the systolic blood pressure during and following lead...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0497-y
更新日期:2016-04-01 00:00:00
abstract::Metallic tin powder injected into Lewis rats caused marked enlargement of draining lymph nodes with prominent hyperplasia of plasma cells. A low level of dietary protein (8%) or deficiency of choline interfered with the cellular proliferation and reduced the size of the nodes by nearly one-third compared to a normal p...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:85:1:71
更新日期:2002-01-01 00:00:00
abstract::Variations in trace element concentration in the head and facial hair of five individuals with ever-increasing amounts of white hair were examined. Hair was collected from the scalp, cheeks, and chin from one donor on a regular basis since 1984. Samples were separated into white and pigmented fractions, and analyzed a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992728
更新日期:1990-07-01 00:00:00
abstract::The effect ofin utero zinc deficiency on fetal development in rats is reviewed. Attention is paid to the primary biochemical lesion associated with zinc-related teratogenesis and special consideration is given to the central nervous system. Evidence is presented that the thymidine kinase salvage pathway, used for the ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916569
更新日期:1985-03-01 00:00:00
abstract::The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 6 per group). Each group received 1 mL (intragastrically) of...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0293-8
更新日期:2015-09-01 00:00:00
abstract::Plasma concentrations of a zinc carrier peptide, namely thymulin, were measured according to a bioassay in young donors, healthy elderly, and patients with senile dementia of Alzheimer's type (SDAT). Thymulin is a hormone released by thymic epithelial cells and its biological activity on cells of immune system is depe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790147
更新日期:1996-01-01 00:00:00
abstract::The effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using Akt2 and IRS1 gene expression methods in streptozotocin-induced diabetic rats. Fifty rats were randomly divided into five experimental groups: 1, non-diabetic control (NDC); 2, Mg2+-treated non-diabet...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1555-z
更新日期:2019-08-01 00:00:00
abstract::Osteoblast L-type voltage-dependent calcium channels (VDCC) play important roles in maintaining intracellular homeostasis and influencing multiple cellular processes. In particular, they contribute to the activities and functions of osteoblasts (OBs). In order to study how L-type VDCC modulate calcium ion (Ca(2+)) hom...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0118-1
更新日期:2014-12-01 00:00:00
abstract::Hexavalent chromium (Cr(VI)) is present in the marine environment and is a known carcinogen and reproductive toxicant. Cr(VI) is the form of chromium that is well absorbed through the cell membrane. It is also the most prevalent form in seawater. We measured the total Cr levels in skin biopsies obtained from healthy f...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0311-x
更新日期:2015-07-01 00:00:00
abstract::Assessing the ability of a selenium (Se) sample to induce cellular glutathione peroxidase (GPx) activity in Se-deficient animals is the most commonly used method to determine Se bioavailability. Our goal is to establish a Se-deficient cell culture model with differential incorporation of Se chemical forms into GPx, wh...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8097-8
更新日期:2008-07-01 00:00:00
abstract::Selenoproteins and selenium (Se) play important roles in the immune system. Selenoprotein expression in the immune system of mammals is sensitive to dietary Se levels; however, little is known about the expression of selenoproteins and their immune functions in the chicken thymus. We assessed selenoprotein gene expres...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0282-y
更新日期:2015-09-01 00:00:00
abstract::Concentrations of selected metals (Cu, Mn, Zn, Cd) in tea leaves were investigated. Samples included black, green, and other (red, white, yellow, and oolong) teas. They were purchased on a local market but they covered different countries of origin. Beverages like yerba mate, rooibos, and fruit teas were also included...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1140-x
更新日期:2018-06-01 00:00:00
abstract::Arsenic (As), antimony (Sb), and bismuth (Bi) are metalloids that share similar chemical properties, the objective of this study was to characterize the uptake and accumulation of these metalloids by plants colonized on heavy contaminated sites in an old Sb mine. Sixty-five plant samples from seven species as well as ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9017-x
更新日期:2011-12-01 00:00:00
abstract::The current information about the effect of physical exercise on the body concentrations of several minerals is still limited, both in the acute (short-term) and adaptive (long-term) responses. So, this manuscript aims, on the one hand, to assess the possible differences on basal levels of cobalt (Co), copper (Cu), an...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-018-1500-1
更新日期:2019-06-01 00:00:00
abstract::The movement of copper and zinc from the fertilized egg into the developing embryo and the subsequent association of the two metals with metallothionein-like proteins (MT) of chick liver was investigated. Hepatic levels of MT in 1-d-old chicks, estimated from specifically bound(115m)Cd, were increased eightfold over e...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02988942
更新日期:1983-12-01 00:00:00