The Effect of Exposure to Cd and Pb in the Form of a Drinking Water or Feed on the Accumulation and Distribution of These Metals in the Organs of Growing Wistar Rats.

Abstract:

:The degree of accumulation and distribution of Cd and Pb in the organs of young animals compared to the amount taken in with water or feed have not been thoroughly investigated yet. The experiment aimed to verify whether the source of toxic metals (feed, drinking water) administered to growing rats orally has an influence on the degree of accumulation of Cd and Pb in the organs (brain, spleen, lungs, heart, liver and kidneys). The rats received Cd and/or Pb respectively in the amount of 7 mg and/or 50 mg per 1 kg of feed or per 1 L of distilled water. The rats' organs accumulated in total about 0.5 % Cd and about 0.71 % Pb consumed with water and about 0.46 % Cd and about 0.63 % Pb taken in with feed. More than 60 % of Cd and more than 70 % of Pb absorbed by the studied organs was accumulated in the liver, and more than 30 % of Cd and 26-29 % of Pb in the kidneys and less than 1 % in other organs. The relationship between the distribution percentage of Cd in the studied organs can be presented as: liver > kidneys > brain > lungs > heart > spleen. The relationship between the distribution percentage of Pb can be presented as: liver > kidneys > brain > spleen > heart > lungs. Significantly (P < 0.05), more Cd and Pb were accumulated in total in the organs of rats receiving the metals in drinking water.

journal_name

Biol Trace Elem Res

authors

Winiarska-Mieczan A,Kwiecień M

doi

10.1007/s12011-015-0414-4

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

230-6

issue

2

eissn

0163-4984

issn

1559-0720

pii

10.1007/s12011-015-0414-4

journal_volume

169

pub_type

杂志文章
  • Effect of zinc supplementation on antioxidant activity in young wrestlers.

    abstract::This study aims to examine the effect of zinc supplementation on free-radical formation and antioxidant system in individuals who are actively engaged in wrestling as a sport. The study registered a total of 40 male subjects, of whom 20 were wrestlers and 20 were sedentary individuals. The subjects were equally alloca...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8457-z

    authors: Kara E,Gunay M,Cicioglu I,Ozal M,Kilic M,Mogulkoc R,Baltaci AK

    更新日期:2010-04-01 00:00:00

  • Feasibility of breast cancer screening by PIXE analysis of hair.

    abstract::To reveal the role of key elements present in the hair of breast cancer patients on cancer development, the levels of a number of elements in scalp hair samples of 82 people including healthy individuals, people suffering from benign breast disease, and breast cancer patients were measured by PIXE analysis. Pellets of...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-013-9671-2

    authors: Gholizadeh N,Kabiri Z,Kakuee O,Saleh-Kotahi M,Changizi V,Fathollahi V,Oliaiy P,Omranipour R

    更新日期:2013-06-01 00:00:00

  • Protective effect of selenomethionine on aflatoxin B1-induced oxidative stress in MDCK cells.

    abstract::AFB1 is a mycotoxin which exerts their cytotoxicity through increasing oxidative damage in target organ. Kidney is one of target organs vulnerable to damage caused by AFB1. In this study, Madin-Darby canine kidney (MDCK) cells were used to evaluate the AFB1-induced cell damage by the MTT assay. The results revealed th...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-014-9887-9

    authors: Parveen F,Nizamani ZA,Gan F,Chen X,Shi X,Kumbhar S,Zeb A,Huang K

    更新日期:2014-03-01 00:00:00

  • Salmonella-macrophage interactions upon manganese supplementation.

    abstract::Various studies indicate the role of manganese (Mn) in the virulence of pathogens. Salmonella is an intracellular pathogen which is able to multiply within the macrophages. The present study was therefore, designed to assess the effect of Mn supplementation on Salmonella-macrophage interactions particularly in referen...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8406-x

    authors: Rishi P,Jindal N,Bharrhan S,Tiwari RP

    更新日期:2010-01-01 00:00:00

  • Influence of the coat color on the trace elemental status measured by particle-induced X-ray emission in horse hair.

    abstract::The influence of hair color on the trace elemental status in horse's hair has been studied. A current analytical technique such as particle-induced X-ray emission (PIXE) used in this study has provided reliable, rapid, easy, and relatively inexpensive diagnostic methods. Twenty-eight elements (Al, Br, Ca, Cl, Co, Cu, ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:103:2:169

    authors: Asano K,Suzuki K,Chiba M,Sera K,Matsumoto T,Asano R,Sakai T

    更新日期:2005-02-01 00:00:00

  • Selective recovery of uranium and thorium ions from dilute aqueous solutions by animal biopolymers.

    abstract::Selective actinide ion recovery from dilute, aqueous, multication waste streams is an important problem. The recovery of uranium (U) and thorium (Th) by various animal biopolymers was examined. Of four species of biopolymers tested, a high uptake of uranium and thorium was found in hen eggshell membrane (ESM) and silk...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/bter:86:3:227

    authors: Ishikawa S,Suyama K,Arihara K,Itoh M

    更新日期:2002-06-01 00:00:00

  • A Systematic Review and Meta-analysis on Blood Lead Level in Opium Addicts: an Emerging Health Threat.

    abstract::This meta-analysis was conducted aiming to summarize the results obtained from the previous studies so that the effect of opium on blood lead levels (BLLs) can be investigated. Scopus, Embase, PubMed, and Web of Science (ISI) were systematically searched up to June 2020. Heterogeneity of the included studies was evalu...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02504-1

    authors: Tabrizi R,Sarihi S,Moazzen F,Hosseini-Bensenjan M,Malekpour F,Asadikaram G,Momeni-Moghaddam MA,Akbari H

    更新日期:2020-11-26 00:00:00

  • The acute and chronic effects of monosodium L-glutamate on serum iron and total iron-binding capacity in the jugular artery and vein of pigs.

    abstract::We analyzed the effects of acute and chronic oral administration of monosodium L-glutamate (MSG) on serum iron (Fe) levels and total iron-binding capacity (TIBC) in piglets. In the first experiment, 12 piglets were randomly assigned to two groups: one fed a standard diet (SD) and the other fed an SD containing MSG (10...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-013-9668-x

    authors: Xin W,Xugang S,Xie C,Li J,Hu J,Yin YL,Deng ZY

    更新日期:2013-06-01 00:00:00

  • Calcium Channels, Rho-Kinase, Protein Kinase-C, and Phospholipase-C Pathways Mediate Mercury Chloride-Induced Myometrial Contractions in Rats.

    abstract::Adverse effects of mercury on female reproduction are reported; however, its effect on myogenic activity of uterus and mechanism thereof is obscure. Present study was undertaken to unravel the mechanistic pathways of mercuric chloride (HgCl2)-induced myometrial contraction in rats. Isometric tension in myometrial stri...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-018-1379-x

    authors: Koli S,Prakash A,Choudhury S,Mandil R,Garg SK

    更新日期:2019-02-01 00:00:00

  • Assessment of 12 Metals and Metalloids in Blood of General Populations Living in Wuhan of China by ICP-MS.

    abstract::Assessment of trace element levels in general population from the specific area is of importance for nutritional and occupational monitoring. In the current study, baseline blood levels of 12 toxic and/or essential metals and metalloids, including arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), chromium (Cr), tha...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-018-1486-8

    authors: Zeng HL,Li H,Lu J,Guan Q,Cheng L

    更新日期:2019-06-01 00:00:00

  • Selenite or selenomethionine interaction with methylmercury on uptake and toxicity showing a weak selenite protection: studies on cultured K-562 cells.

    abstract::Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:80:3:251

    authors: Frisk P,Yaqob A,Nilsson K,Lindh U

    更新日期:2001-06-01 00:00:00

  • Magnesium, zinc, and manganese in atherosclerosis of the aorta.

    abstract::Atomic absorption spectrometry was used in a quantitative study of zinc, magnesium, and manganese on 71 postmortal human aortas. Samples were obtained from accident victims 35-65 years of age. Fibrous plaques had higher levels of all three elements when compared to normal aortic tissue. The difference was significant ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02916613

    authors: Mendis S

    更新日期:1989-12-01 00:00:00

  • Effects of low copper and high zinc intakes and related changes in Cu,Zn-superoxide dismutase activity on DMBA-induced mammary tumorigenesis.

    abstract::The effect of low copper and high zinc intakes on Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activity and mammary tumorigenesis induced by 9,10-dimethyl-1,2-benzanthracene (DMBA) was investigated. Groups of 40 weanling female Sprague-Dawley rats were fed a modified AIN-76 diet containing the following (/kg diet): 1 mg Cu ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02990343

    authors: Fischer PW,Campbell JS,Giroux A

    更新日期:1991-07-01 00:00:00

  • High dietary aluminum affects the response of rats to silicon deprivation.

    abstract::Antagonistic interactions between silicon and aluminum occur in living organisms. Thus, an experiment was performed to ascertain whether high dietary aluminum would accentuate the signs of silicon deprivation in rats and conversely whether silicon deprivation would accentuate the response to high dietary aluminum. The...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02917430

    authors: Seaborn CD,Nielsen FH

    更新日期:1994-06-01 00:00:00

  • Effects of formaldehyde inhalation on zinc, copper and iron concentrations in liver and kidney of male rats.

    abstract::In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8686-1

    authors: Ozen OA,Kus I,Bakirdere S,Sarsilmaz M,Yaman M

    更新日期:2011-05-01 00:00:00

  • Distribution of 14 elements in various rat tissues following hypophysectomy, thyroparathyroidectomy, adrenalectomy, and castration.

    abstract::The tissue distribution of 14 elements was simultaneously determined in rats 28 d after hypophysectomy (HPY), thyroparathyroidectomy (TPTY), adrenalectomy (ADY), and castration (CTN). The elements Na, K, Ca, Mg, Fe, S, P, Rb, Sr, Mn, Cu, and Zn were investigated in whole blood, plasma, brain, liver, kidney, heart, ske...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02797096

    authors: LeBlondel G,Ducouret C,Allain P

    更新日期:1988-07-01 00:00:00

  • Trace Elements in the Large Population-Based HUNT3 Survey.

    abstract::The Nord-Trøndelag Health Study (The HUNT Study) is a large health survey population study in the county of Trøndelag, Norway. The survey has been repeated four times in about 10-year intervals. In the HUNT3 survey (2006-2008), we collected 28,000 samples for trace element analysis. Blood samples from 758 healthy pers...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02376-5

    authors: Syversen T,Evje L,Wolf S,Flaten TP,Lierhagen S,Simic A

    更新日期:2020-09-08 00:00:00

  • Chromium Is Elevated in Fin Whale (Balaenoptera physalus) Skin Tissue and Is Genotoxic to Fin Whale Skin Cells.

    abstract::Hexavalent chromium (Cr(VI)) is present in the marine environment and is a known carcinogen and reproductive toxicant. Cr(VI) is the form of chromium that is well absorbed through the cell membrane. It is also the most prevalent form in seawater. We measured the total Cr levels in skin biopsies obtained from healthy f...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0311-x

    authors: Wise CF,Wise SS,Thompson WD,Perkins C,Wise JP Sr

    更新日期:2015-07-01 00:00:00

  • Induction and characterization of metallothionein in different organs of Ostrea edulis L.

    abstract::In this study, the induction of metallothionein (MT) in one species of oyster Ostrea edulis exposed to copper (Cu) and zinc (Zn) was examined. The quantity of total protein (mg protein/mg dry wt) in each sample and the measurement of MT were determined by the Lowry and silver (Ag)-saturation methods. Our results show ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784547

    authors: Alonso JI,Martin-Mateo MC

    更新日期:1996-07-01 00:00:00

  • Protective effects of selenium, zinc, or their combination on cadmium-induced oxidative stress in rat kidney.

    abstract::The present study was conducted to investigate whether the combined treatment with Se and Zn offers more beneficial effects than that provided by either of them alone in reversing Cd-induced oxidative stress in the kidney of rat. For this purpose, 30 adult male Wistar albino rats, equally divided into control and four...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8324-y

    authors: Messaoudi I,El Heni J,Hammouda F,Saïd K,Kerkeni A

    更新日期:2009-08-01 00:00:00

  • A Cross-sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men.

    abstract::Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA us...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02468-2

    authors: Kondrakhina IN,Verbenko DA,Zatevalov AM,Gatiatulina ER,Nikonorov AA,Deryabin DG,Kubanov AA

    更新日期:2020-11-05 00:00:00

  • Effects of selenium overexposure on glutathione peroxidase and thioredoxin reductase gene expressions and activities.

    abstract::Selenium (Se) is an essential trace element in animals and human, however, excess Se intake can result in adverse health effects. Se supplementation increased glutathione peroxidase (GSH-Px) and thioredoxin reductase (TR) expressions in Se-deficient rats. However, little information is available on the relationship be...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:89:2:165

    authors: Gan L,Liu Q,Xu HB,Zhu YS,Yang XL

    更新日期:2002-11-01 00:00:00

  • Effects of zinc on interleukins and antioxidant enzyme values in psoriasis-induced mice.

    abstract::The effects of zinc chloride (ZnCl2), disodium zinc ethylenediamine tetraacetate (Zn-EDTA), and zinc gluconate (Zn-GLU) on the antioxidant enzyme activities and levels of interleukins (ILs) in psoriasis-induced mice were studied. One hundred twenty female mice were randomly divided into six groups with 20 mice in each...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-013-9799-0

    authors: Yin LL,Zhang Y,Guo DM,An K,Yin MS,Cui X

    更新日期:2013-12-01 00:00:00

  • Correlation between maternal plasma homocysteine and zinc levels in preeclamptic women.

    abstract::Women with preeclampsia have been shown to have elevated blood levels of the metabolite homocysteine, and alterations in blood levels of zinc and copper have also been reported. This study measured plasma levels of zinc, copper, and homocysteine in women with preeclampsia and in women with healthy, normotensive pregna...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:104:2:097

    authors: Harma M,Harma M,Kocyigit A

    更新日期:2005-05-01 00:00:00

  • Experimental Research Showing the Reduction of Naloxone-Place Aversion by Oral Zinc Administration in Rats.

    abstract::Previous studies showed the attenuation of both morphine-dependence and morphine-place preference by zinc. Conditioned place preference and aversion are experimental models frequently used to test the reward-stimulating, respectively the aversive effects induced by different stimuli or substances. Addictive substances...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-0995-1

    authors: Ciubotariu D,Lupușoru RV,Luca E,Mititelu-Tarțău L,Lupușoru CE

    更新日期:2017-11-01 00:00:00

  • Cerium Oxide Nanoparticles Attenuate Oxidative Stress and Inflammation in the Liver of Diethylnitrosamine-Treated Mice.

    abstract::The catalytic activity of cerium oxide nanoparticles (CeO2NPs) is responsible for its application as an antitumor agent. This activity may be due to its ability to switch between III and IV oxidation states thereby conferring pro- and antioxidant properties. This study was designed to assess the hepatoprotective poten...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01696-5

    authors: Adebayo OA,Akinloye O,Adaramoye OA

    更新日期:2020-01-01 00:00:00

  • Leptin concentration and the Zn/Cu ratio in plasma in women with thyroid disorder.

    abstract::We investigated the possible correlation between the leptin concentration and the Zn/Cu ratio in the plasma of women with thyroid disorder. Forty women with hypothyroidism (n = 20) or hypothyroidism (n = 20) and 20 euthyroid controls were recruited. The results showed that the women with thyroid disorder (hypothyroidi...

    journal_title:Biological trace element research

    pub_type: 临床试验,杂志文章

    doi:10.1385/BTER:75:1-3:99

    authors: Chen MD,Song YM,Tsou CT,Lin WH,Sheu WH

    更新日期:2000-07-01 00:00:00

  • Effect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemia.

    abstract::This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation was evaluated by measuring the levels of malondialdehyde and glut...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:96:1-3:117

    authors: Kurtoglu E,Ugur A,Baltaci AK,Undar L

    更新日期:2003-01-01 00:00:00

  • Study on air pollution in Beijing's major industrial areas using multielements in biomonitors and NAA techniques.

    abstract::Three kinds of plant leaves, Chinese white aspen, arborvitae, and pine needles, have been sampled from the Yanshan Oil refinery complex, the Capital Iron and Steel Factory, and Badachu, a control area in Beijing, as biomonitors for air-pollution studies. Each sample was divided into two parts, washed, and unwashed. Th...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784212

    authors: Ni B,Tian W,Nie H,Wang P,He G

    更新日期:1999-01-01 00:00:00

  • Protective Roles of Selenium on Nitric Oxide and the Gene Expression of Inflammatory Cytokines Induced by Cadmium in Chicken Splenic Lymphocytes.

    abstract::Cadmium (Cd) is an environmental toxicant and an inflammation-related xenobiotic. Selenium (Se) is a well-known nutritional trace element and a potent chemopreventive agent. The present study aimed to investigate the effect of Se on the cytotoxicity of Cd in bird immunocytes in vitro. Chicken splenic lymphocytes expos...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0354-z

    authors: Liu S,Xu F,Fu J,Li S

    更新日期:2015-11-01 00:00:00