Abstract:
:This study was performed to determine the effects of selenium supplementation on clinical symptoms and gene expression related to inflammatory markers in infertile women with polycystic ovary syndrome (PCOS) who were candidate for in vitro fertilization (IVF). Thirty-six women candidate for IVF were recruited in this randomized double-blinded, placebo-controlled trial. They (n = 18/group) were randomly assigned into intervention groups to take either 200 μg/day of selenium or placebo for 8 weeks. RT-PCR findings indicated that selenium supplementation downregulated gene expression of interleukin-1 (IL-1) (P < 0.004) and tumor necrosis factor alpha (TNF-α) (P = 0.02) in lymphocytes of patients with PCOS compared with the placebo. In addition, selenium supplementation upregulated gene expression of vascular endothelial growth factor (VEGF) (P = 0.001) in lymphocytes of patients with PCOS compared with the placebo. Selenium supplementation had no significant effect on clinical symptoms and gene expression of IL-8 (P = 0.10) and transforming growth factor beta (TGF-β) (P = 0.63). Overall, our findings documented that selenium supplementation for 8 weeks to infertile women candidate for IVF improved IL-1, TNF-α, and VEGF gene expression, though selenium had no effect on clinical symptoms and, IL-8 and TGF-β gene expression. Clinical trial registration number: http://www.irct.ir: IRCT20170513033941N23.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Heidar Z,Hamzepour N,Zadeh Modarres S,Mirzamoradi M,Aghadavod E,Pourhanifeh MH,Asemi Zdoi
10.1007/s12011-019-01715-5subject
Has Abstractpub_date
2020-02-01 00:00:00pages
319-325issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-019-01715-5journal_volume
193pub_type
杂志文章,随机对照试验abstract::Selenium (Se) mainly performs its function through Se-containing proteins. Selenoprotein W (SelW), one member of the selenoprotein family, plays important roles in the normal function of the heart. To investigate the possible relationship between Se and SelW for the regulation of oxidative damage in chicken embryo myo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0529-7
更新日期:2016-06-01 00:00:00
abstract::Being a proven photocatalyst, nano-anatase is capable of undergoing electron transfer reactions under light. In previous studies, we had proven that nano-anatase improved photosynthesis and greatly promoted spinach growth. However, the molecular mechanisms of carbon reaction promoted by nano-anatase are still not clea...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8203-y
更新日期:2008-01-01 00:00:00
abstract::This study aimed to investigate the effect of zinc (Zn), selenium (Se), and vitamin E (Vit E) administration on semen quality and fertility in male dromedary camels with impotentia generandi (IG, post-coital infertility). Factors that may affect response to treatment were investigated. Thirty-three IG-affected and fiv...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02276-8
更新日期:2020-07-06 00:00:00
abstract::The effect ofin utero zinc deficiency on fetal development in rats is reviewed. Attention is paid to the primary biochemical lesion associated with zinc-related teratogenesis and special consideration is given to the central nervous system. Evidence is presented that the thymidine kinase salvage pathway, used for the ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916569
更新日期:1985-03-01 00:00:00
abstract::Lipid disturbance induced by high-fat diet is a worldwide problem, and it can induce inflammation and oxidative stress in vivo. Zinc is considered as an antioxidant, anti-inflammatory agent. Since matrix metalloprotease 2 (MMP2) and matrix metalloprotease 9 (MMP9)'s expressions are changed under many pathological cond...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0367-7
更新日期:2015-12-01 00:00:00
abstract::In this study, experimental hyperthyroidism was established and used to investigate possible alterations in the calcium (Ca), magnesium (Mg), and zinc (Zn) homeostasis by assessing their concentrations in plasma and erythrocytes. In the L-thyroxine-induced hyperthyroidism condition, the experimental animals show a sig...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02778196
更新日期:1997-05-01 00:00:00
abstract::We analyzed the effects of acute and chronic oral administration of monosodium L-glutamate (MSG) on serum iron (Fe) levels and total iron-binding capacity (TIBC) in piglets. In the first experiment, 12 piglets were randomly assigned to two groups: one fed a standard diet (SD) and the other fed an SD containing MSG (10...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9668-x
更新日期:2013-06-01 00:00:00
abstract::Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association ...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析
doi:10.1007/s12011-017-0982-6
更新日期:2017-10-01 00:00:00
abstract::Oxidative stress is a main factor in the pathogenesis of severe acute pancreatitis (SAP). The ability of zinc (Zn) to retard oxidative processes has been recognized for many years. This study aims to examine the levels of free oxygen radicals and antioxidant enzyme in SAP rats and know the effect of Zn supplementation...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9971-1
更新日期:2014-06-01 00:00:00
abstract::Among the trace elements, zinc is one of the most used elements in biological systems. Zinc is found in the structure of more than 2700 enzymes, including hydrolases, transferases, oxyreductases, ligases, isomerases, and lyases. Not surprisingly, it is present in almost all body cells. Preserving the stability and int...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/s12011-017-1119-7
更新日期:2018-05-01 00:00:00
abstract::Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02402-6
更新日期:2020-10-06 00:00:00
abstract::The liver of Hooded Seal (Cystophora cristata) consists of six lobes of unequal sizes. Extensive sampling by means of cutout samples covering the depth horizon 2-30 mm below liver surface indicates that the liver may be considered homogeneous as to concentrations of zinc, cadmium, mercury, and selenium (residuals of o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789141
更新日期:1990-01-01 00:00:00
abstract::The current study was conducted in order to investigate the short-term effects (6, 12, and 24 h) of silicon (Si) on the endogenous hormonal composition of rice (Oryza sativa L. cv. Dongjin-beyo), with and without wounding stress. Si applied in different concentrations (0.5, 1.0, and 2.0 mM) significantly promoted shoo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9047-4
更新日期:2011-12-01 00:00:00
abstract::Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1077-0
更新日期:2018-03-01 00:00:00
abstract::Oxidative stress plays a crucial role in the pathogenesis of multiple sclerosis (MS). Previous studies have shown that oxidative stress is one of the main underlying mechanisms of arsenic-induced cellular damage. The aim of this study was to assess the serum levels of arsenic and its relationship with lipid peroxidati...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9956-0
更新日期:2014-06-01 00:00:00
abstract::Rare earth elements can promote photosynthesis, but their mechanisms are still poorly understood under magnesium deficiency. The present study was designed to determine the role of cerium in magnesium-deficient maize plants. Maize was cultivated in Hoagland's solution added with cerium with and without adequate quanti...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8769-z
更新日期:2011-09-01 00:00:00
abstract::Zinc is a nutritionally essential trace element required for many biological functions to be successfully carried out. The aim of the present work was to study the influence of zinc on the intestinal absorption of L-threonine and on the aminopeptidase N activity in rabbit jejunum, after in vitro addition and/or oral a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784557
更新日期:1996-07-01 00:00:00
abstract::The objective was to determine if a mammary cell line shows glucocorticoid stimulation of Zn uptake, and to determine whether polyamines mediate this stimulation. 65Zn uptake by COMMA-1D mouse mammary epithelial cells over a 24-h period increased significantly in cells administered 10(-7) or 10(-6) M hydrocortisone. I...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783193
更新日期:1993-11-01 00:00:00
abstract::Renal functions were damaged at the reabsorptive site by the injection of cadmium-metallothionein (Cd-MT) and its effect on discrimination of chemically similar elements was examined for the two alkaline-earth elements, calcium (Ca) and strontium (Sr). Tubular damage was induced in female Wistar rats, 7 wk old, body w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917418
更新日期:1989-10-01 00:00:00
abstract::Trace minerals and vitamins are known modulators of bone metabolism, and dietary optimization of these components may improve skeletal development and reduce the occurrence of skeleton deformities in farmed fish. As for larval stages, mineral and water-soluble vitamin nutrition requirements are lacking in research eff...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01939-5
更新日期:2020-08-01 00:00:00
abstract::This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO4) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO4 strongly inhibited the replic...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01728-0
更新日期:2020-02-01 00:00:00
abstract::Zinc has been shown to increase bone mass and promote bone cell proliferation and differentiation. We, therefore, hypothesized that zinc might be cytoprotective for bone cells during oxidative stress. The cells were divided into H(2)O(2), zinc and zinc+H(2)O(2) groups. In the present study, zinc was found to inhibit H...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9387-8
更新日期:2012-09-01 00:00:00
abstract::The objective of this study was to determine whether different dietary vitamin E (VE) and selenium (Se) levels affect the nutrient digestibility, production performance, and antioxidant abilities of growing furring blue foxes. A 4 × 2 factorial arrangement that included 4 levels of VE (0, 100, 200, or 400 mg/kg diet f...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-1655-4
更新日期:2019-12-01 00:00:00
abstract::Multielemental detection using Instrumental Neutron Activation Analysis (INAA) and Proton-Induced X-Ray Emission (PIXE) of drinkable water of Florence (Italy) is described. The concentrations of 52 elements were measured. No chemical treatment was performed on the samples, before or after irradiation. On the basis of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992691
更新日期:1990-07-01 00:00:00
abstract::Copper (Cu) and zinc (Zn) are involved in inflammatory process. This study was to investigate the clinical significance of Cu and Zn homeostasis alterations in acute appendicitis (AA). One hundred twenty-two AA patients and 102 healthy controls were enrolled in this study. Of which, 85 patients' appendixes were collec...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01661-2
更新日期:2019-12-01 00:00:00
abstract::Zinc and fluorides are capable of modifying the process of bone formation and mineralization. Statistically significant differences have been revealed in the content of zinc and fluorides between structures of the femur in chicken. The content of zinc in compact bone remained constant during the first 50 d of life. Lo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:91:1:67
更新日期:2003-01-01 00:00:00
abstract::Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:80:3:251
更新日期:2001-06-01 00:00:00
abstract::This experiment was conducted to evaluate the effects of zinc (ZnSO4.H2O) and vitamin A (retinol) supplementation on performance, carcass characteristics, and serum concentrations of glucose, cholesterol, total protein, and malondialdehyde (MDA) as an indicator of lipid peroxidation in broiler chickens (Ross) reared a...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1385/BTER:94:3:225
更新日期:2003-09-01 00:00:00
abstract::The tissue distribution of 14 elements was simultaneously determined in rats 28 d after hypophysectomy (HPY), thyroparathyroidectomy (TPTY), adrenalectomy (ADY), and castration (CTN). The elements Na, K, Ca, Mg, Fe, S, P, Rb, Sr, Mn, Cu, and Zn were investigated in whole blood, plasma, brain, liver, kidney, heart, ske...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02797096
更新日期:1988-07-01 00:00:00
abstract::The purpose of this 42-day study was to investigate the effects of dietary excess vanadium on spleen growth and lesions by determining morphological changes and cell cycle of spleen. Four hundred twenty 1-day-old avian broilers were divided into six groups and fed on a corn-soybean basal diet as control diet or the sa...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8938-0
更新日期:2011-11-01 00:00:00