Abstract：
:The objective was to determine if a mammary cell line shows glucocorticoid stimulation of Zn uptake, and to determine whether polyamines mediate this stimulation. 65Zn uptake by COMMA-1D mouse mammary epithelial cells over a 24-h period increased significantly in cells administered 10(-7) or 10(-6) M hydrocortisone. Incorporation of 65Zn over a 1-h period was not hydrocortisone-responsive, suggesting that these incubation times represent uptake into different pools. The rate of entry into the cells over a 15-min period was significantly increased by supplementing cells with hydrocortisone with or without prolactin. Initially, cells grown in lactogenic hormone-supplemented media (10(-6) M hydrocortisone + 5 micrograms/mL ovine prolactin) had up to 65% greater 65Zn uptake over 24 h than cells in nonsupplemented growth media. 65Zn uptake from hormone media with the spermidine synthesis inhibitor methylglyoxal-bis-(guanylhydrazone) (MGBG, 10(-5)M) added was less than from growth media. Exogenous spermidine (10(-6)-10(-3)M) added to the MGBG + hormone media increased 65Zn uptake. Difluoromethylornithine (DFMO), an inhibitor of spermidine synthesis that blocks ornithine decarboxylase, caused a slight dose-dependent decrease in 65Zn uptake over the range 10(-6)-5 x 10(-3)M (p < 0.002) and tended to decrease 65Zn-uptake in lactogenic hormone-stimulated cells with 8 h of incubation, but not at other times. These data show that Zn uptake in mammary epithelial cells can be hormonally mediated by glucocorticoids and suggest that polyamines may be intracellular mediators of this effect.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Allen JC,Vaillancourt SJ,Haedrich Ldoi
10.1007/BF02783193subject
Has Abstractpub_date
1993-11-01 00:00:00pages
229-43issue
2-3eissn
0163-4984issn
1559-0720journal_volume
39pub_type
杂志文章abstract：:The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, so...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:80:1:53
更新日期：2001-04-01 00:00:00
abstract：:Extracellular Ca2+-influx induced by trivalent metal ions (Fe3+, Al3+, Cr3+, In3+, Ga3+, and La3+) in Ehrlich carcinoma cells is enhanced by ATP. This action seems to be related to the high coordination capacity of the ATP ligand that inhibits the polymerization of the solvated cations taking place at physiological pH...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02820027
更新日期：1998-04-01 00:00:00
abstract：:The toxic effect of Pb2+ has been studied in eukaryotic cells by using Tetrahymena as a target. The maximum power (P(m)) and the growth rate constant (k) were determined, which showed that values of P(m) and k were linked to the concentration (C) of Pb2+. The addition of Pb2+ caused a decrease of the maximum heat prod...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0055-3
更新日期：2007-11-01 00:00:00
abstract：:Issues regarding biomagnification of mercury (Hg) due to its persistence, bioaccumulation, and toxicity in freshwater lakes have gained much attention in the last two decades especially in remote regions of the world where anthropogenic inputs are considered as negligible. In this study, spatial distribution of total ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02479-z
更新日期：2021-01-07 00:00:00
abstract：:Quantitative analysis of follicular fluid and granulosa cells from small, medium and large antral atretic follicles of goat (Capra hircus) ovaries was conducted to study the alterations in trace elements viz zinc (Zn), copper (Cu), manganese (Mn), and iron (Fe). The zinc content was lower in the follicular fluid (0.99...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8700-7
更新日期：2011-06-01 00:00:00
abstract：:Daily ingestion of lead (Pb), even through piped drinking water, has long time been an important issue of concern, attracting for decades research in environmental science and toxicology, and again comes to prominence because of recent high-profile cases of exposure of populations in several countries to Pb-contaminat...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-018-1336-8
更新日期：2018-12-01 00:00:00
abstract：:This study evaluated the effects of the different dietary zinc (Zn) levels on semen quality, on spermatozoa and seminal plasma antioxidant status, and on the seminal and blood plasma mineral status in mature male Cashmere goats during the breeding season. Twenty-eight mature male Liaoning Cashmere goats were divided i...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01933-x
更新日期：2020-08-01 00:00:00
abstract：:A 10-year-old Gir bullock was presented with four contiguous hard nodular submucosal masses attached to the right rostral mandible. Overgrown masses were resected surgically and submitted for microstructural, elemental, and molecular spectroscopic analyses. An osteoma was diagnosed histopathologically. Elemental analy...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-021-02604-6
更新日期：2021-01-26 00:00:00
abstract：:Woodlice are top consumers of a three-trophic system (soil, leaf litter, woodlice), and they are closely related to pollutant absorbing surfaces such as soil, leaf litter, and organic matter. We studied the effects of urbanization on trace element concentrations and fluctuating asymmetry of Armadillidium vulgare (Crus...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1454-3
更新日期：2019-05-01 00:00:00
abstract：:It has been demonstrated that zinc exerts its beneficial influence on skin fibroblasts. Propolis, a complex mixture of plant-derived and bees' products, was reported to stimulate cicatrization processes in skin and prevent infections. The aim of this study was to find out how zinc and propolis influence human skin fib...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0019-3
更新日期：2014-07-01 00:00:00
abstract：:The degree of chromosome damage induced by three compounds of zinc (zinc chloride, zinc sulfate, zinc acetate) was compared in human leucocytes in vitro. Three concentrations of each salt, 3.0 x 10(-5)M, 3.0 x 10(-4)M, and 1.5 x 10(-3)M, were added to leukocyte cultures. The cells were harvested after 48 and 72 h and ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:78:1-3:113
更新日期：2000-01-01 00:00:00
abstract：:Strontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a bone-seeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9158-y
更新日期：2012-01-01 00:00:00
abstract：:The present study was conducted to investigate whether the combined treatment with Se and Zn offers more beneficial effects than that provided by either of them alone in reversing Cd-induced oxidative stress in the kidney of rat. For this purpose, 30 adult male Wistar albino rats, equally divided into control and four...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8324-y
更新日期：2009-08-01 00:00:00
abstract：:In vitro tests simulating the elements release from inhaled urban particulate matter (PM) with artificial lung fluids (Gamble's and Hatch's solutions) and simulated gastric and pancreatic solutions were applied for an estimation of hazardous element (As, Cd, Cr, Hg, Mn, Ni, Pb and Zn) bio-accessibility in this materia...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0101-x
更新日期：2014-11-01 00:00:00
abstract：:Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1077-0
更新日期：2018-03-01 00:00:00
abstract：:Obesity is a major public health problem worldwide and a risk factor for certain diseases, including cardiovascular disease, diabetes, cancer, and depression. Unfortunately, currently available anti-obesity drugs have failed in the long-term maintenance of weight control. It has been a challenge to design novel drugs ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01738-y
更新日期：2020-02-01 00:00:00
abstract：:Lead poisoning is a worldwide health problem, and its treatment is under investigation. The aim of this study was to access the efficacy of Coriandrum sativum (coriander) in reducing lead-induced changes in mice testis. Animal exposed to lead nitrate showed significant decrease in testicular SOD, CAT, GSH, total prote...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8553-0
更新日期：2010-09-01 00:00:00
abstract：:Magnesium is the second most abundant intracellular cation and is a fundamental cofactor in a multitude of cellular enzymatic reactions. Magnesium deficiency causes diverse clinical features predominantly due to cardio- and neurotoxicity. We describe a case of severe hypomagnesaemia associated with intermittent downbe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8757-3
更新日期：2011-08-01 00:00:00
abstract：:X-ray Fluorescence (XRF) Analysis and Atomic Absorption Spectrophotometry (AAS) have been used in assessing heavy metal pollution from some gold mines in Ghana. The presence and levels of heavy metals in gold ore, gold tailings, inland waters, and river sediments have been determined. Using these techniques, the heavy...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992682
更新日期：1990-07-01 00:00:00
abstract：:In this study, a method of positive matrix factorization (PMF) combined support vector machines (SVMs) was adopted to identify possible sources and apportion contributions for trace element pollution in surface sediments from the Jinjiang River, Southeastern China. Utilizing diagnostics tools, four significant factors...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9576-5
更新日期：2013-03-01 00:00:00
abstract：:A study was conducted to determine the effect of dietary selenium (Se) concentration and source for broiler chickens on performance, nutrient digestibility, plasma Se, glutathione peroxidase (GPx) activity, and thiobarbituric acid reactive substances (TBARS). A total of 700 1-day-old broiler chicks were assigned to 7 ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01801-8
更新日期：2020-04-01 00:00:00
abstract：:Human serum butyrylcholinesterase (BChE) has been converted into a stable but less active desensitized form when heated at 45 degrees C for 24 h. The desensitized BChE follows Michaelis-Menten kinetics, whereas native enzyme exhibits slightly negative cooperativity with respect to butyrylthiocholine binding. In this s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:93:1-3:55
更新日期：2003-07-01 00:00:00
abstract：:To investigate the protective effect of garlic powder on cadmium-induced toxicity sea bass liver, juvenile fishes where maintained under three food diets (diet 1: normal without garlic supply, diet 2: 2% garlic powder; diet 3: 6% garlic powder). After 30 days of specific diets, each group was injected with 500 μg kg-1...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1146-4
更新日期：2018-06-01 00:00:00
abstract：:In this study, the induction of metallothionein (MT) in one species of oyster Ostrea edulis exposed to copper (Cu) and zinc (Zn) was examined. The quantity of total protein (mg protein/mg dry wt) in each sample and the measurement of MT were determined by the Lowry and silver (Ag)-saturation methods. Our results show ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784547
更新日期：1996-07-01 00:00:00
abstract：:Since waterborne minerals appear in ionic form and are readily absorbed by the gastrointestinal tract, drinking water could be a crucial source of mineral intake. However, no comprehensive research has yet determined how trace elements in drinking water relate to body composition. We aimed to assess the relationship b...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-016-0779-z
更新日期：2017-02-01 00:00:00
abstract：:Deficiencies in Cu, Se, and Zn impair one or more biochemical functions, and excess are associated with toxicity. Baseline studies on the Ghanaian population are scanty. The study was undertaken to determine whether significant rural/urban differences in the serum levels of Cu, Se, and Zn did exist. Forty males/60 fem...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8571-y
更新日期：2010-11-01 00:00:00
abstract：:Yerba mate (Ilex paraguariensis), a widely consumed beverage in South America, contains various biochemically active substances, among them are several minerals. This paper reports on the results of a survey of trace elements in the yerba mate infusions. Three different commercially available trademarks of I. paraguar...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9056-3
更新日期：2011-12-01 00:00:00
abstract：:Plasma chromium concentrations have been determined for 150 patients. These were subjected to coronary artery cineangiography and thereby divided into three groups: group CAD (those with coronary artery disease), group HD (those with heart disease, but no CAD) and group N (those with no CAD and no HD). Weighted, avera...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02989260
更新日期：1984-10-01 00:00:00
abstract：:Our previous studies showed that serum calcium level may have influence in the blood pressure to older male subjects, but the relationship between serum calcium level and blood lipids is unclear. The aim of this study was to evaluate the relationship between total serum calcium level and blood lipids. In our study, to...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9895-9
更新日期：2014-03-01 00:00:00
abstract：:Metallothionein (MT) is a low-mol-wt protein. The essential trace elements copper and zinc and the potentially toxic elements, such as cadmium, can induce the synthesis of and bind to MT. The major functions of MT are related to metal metabolism. This paper reported and evaluated a new method for determination of hepa...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783177
更新日期：1993-02-01 00:00:00
