The effect of aging on the mineral status of female SAMP1 and SAMR1.

Abstract:

:The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, sodium, and potassium concentrations in blood, liver, kidney, brain, and tibia of the mice were determined. The copper concentration in the brain was significantly increased with age in SAMP1 and SAMR1. In addition, the brain copper levels in SAMP1 were significantly higher than that in SAMR1 at respective ages. The calcium concentration in the kidney was significantly increased with age, but the copper and phosphorus concentrations significantly decreased with age in SAMP1 and SAMR1. In the liver of SAMR1, all minerals measured in this study except for sodium and potassium were significantly decreased with age. In addition, all mineral concentrations in the liver of 2-mo-old mice in SAMR1 except for copper and sodium were markedly higher than those in SAMP1 of the same age. These results suggest that the genetic factor is related to the age-associated mineral changes in tissues.

journal_name

Biol Trace Elem Res

authors

Morita A,Abdireyim D,Kimura M,Itokawa Y

doi

10.1385/BTER:80:1:53

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

53-65

issue

1

eissn

0163-4984

issn

1559-0720

pii

BTER:80:1:53

journal_volume

80

pub_type

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