Abstract:
:Experiments were conducted to determine whether the increased glutathione S-transferase (GSH-T) activity associated with selenium (Se) deficiency is necessarily related to losses in the activity of Se-dependent glutathione peroxidase (SeGSHpx) in chicks. Nutritional Se status was altered in two ways: by treatment with an antagonist of Se utilization, aurothioglucose (AuTG), and by feeding diets containing excess Se. Chicks given AuTG (10-30 mg AU/kg, sc) had growth rates and hepatic GSH concentrations that were comparable to those of saline-treated controls; however, their plasma GSH levels exceeded those of either Se-deficient (6-fold) or -adequate (3-fold) saline-treated chicks. Hepatic SeGSHpx activities of AuTG-treated chicks were half those of controls under conditions of Se-adequacy; however, this effect was not detected when Se was deficient. Hepatic GSH-TCDNB (assayed with 1-chloro-2,4-dinitrobenzene) activities of AuTG-treated chicks were significantly greater than those of controls when Se was deficient (i.e., when SeGSHpx activity was 12% of the Se-adequate level); however, deprivation of Se did not affect GSH-TCDNB activity in the absence of AuTG. Chicks fed excess Se (6-20 ppm as Na2SeO3) in diets containing either low (2 IU/kg) or adequate (100 IU/kg) VE, showed hepatic GSH-TCDNB activities and GSH concentrations greater than those of Se-adequate (0.2 ppm Se) chicks by 100% and 40%, respectively. That increased hepatic GSH-TCDNB activity can occur because of either AuTG or excess Se status under conditions wherein SeGSHpx activity is not affected indicates that the transferase response is not directly related to changes in the peroxidase.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Kim YS,Combs GF Jrdoi
10.1007/BF02783792subject
Has Abstractpub_date
1993-05-01 00:00:00pages
165-77issue
2-3eissn
0163-4984issn
1559-0720journal_volume
37pub_type
杂志文章abstract::To elucidate compositional changes of peripheral nerves with aging, the authors investigated age-related changes of elements and their relationships in the optic, trigeminal, vagus, median, radial, ulnar, femoral, sciatic, tibial, and common peroneal nerves by inductively coupled plasma-atomic emission spectrometry. T...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:98:3:229
更新日期:2004-06-01 00:00:00
abstract::The main aim of the study was to determine the role of cerium in the amelioration of calcium-deficiency effects in spinach plants. Spinach plants were cultivated in Hoagland's solution. They were subjected to calcium-deficiency and to cerium chloride administered in the calcium-present Hoagland's media and calcium-def...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8054-y
更新日期:2008-03-01 00:00:00
abstract::Trace element contamination in Chinese herbal medicines has been recognized as a potential health concern for consumers. To assess the health risk to the herb-consuming population, nine trace elements (Cu, Cd, Cr, Mo, Ni, Pb, Sr, Zn, and As) were investigated based on their concentrations in three common medicinal pla...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02539-4
更新日期:2021-01-03 00:00:00
abstract::The hypothesis that oxygen-derived free radicals play an important role in myocardial ischemic and reperfusion injury has received a lot of support. In the presence of catalytic amounts of transition metals such as iron, superoxide anions, and hydrogen peroxide can be transformed into a highly reactive hydroxyl radica...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917218
更新日期:1994-04-01 00:00:00
abstract::An experimental study was conducted in Wistar rats to characterize the arsenic ("As")-induced alterations in neurobiochemistry in brain and its impact on neuropharmacological activities with or without the melatonin (MLT) as an antioxidant given exogenously. Male Wistar rats were randomly divided in to four groups of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1537-1
更新日期:2019-07-01 00:00:00
abstract::The aim of this study was to evaluate and compare the oxidative profiles of three thyroid disorders: Graves' disease (GD), Hashimoto thyroiditis (HT), and papillary thyroid cancer (PTC). Malondialdehyde levels (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities were examined ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8625-1
更新日期:2010-12-01 00:00:00
abstract::Neonatal uptake of mercury (Hg) from milk was examined in a pregnant sheep model, where radioactive mercury (Hg203)/silver tooth fillings (amalgam) were newly placed. A crossover experimental design was used in which lactating ewes nursed foster lambs. In a parallel study, the relationship between dental history and b...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785388
更新日期:1997-02-01 00:00:00
abstract::The exposure of toxic elements may directly or indirectly associate with different pathogenesis of heart diseases. In the present study, the association of arsenic (As), cadmium (Cd), cobalt (Co), lead (Pb), and nickel (Ni) in biological samples (whole blood and urine) and mortality from myocardial infarction (MI) pat...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8713-2
更新日期:2011-06-01 00:00:00
abstract::The relationship between Ni-induced hepatic lipid peroxidation (LPO) and the concentrations of Ni and trace elements was investigated in male ICR mice. The protective effects of antioxidants were also examined. Hepatic LPO and the concentrations of Ni, Fe, Cu, and Zn in the liver were enhanced after an ip injection of...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784030
更新日期:1998-02-01 00:00:00
abstract::Zinc is an essential micronutrient for the organism and is critical for the functional and structural integrity of cells. Determination of the amount of trace element concentrations in tissues such as hair samples have been used for the evaluation of the metabolic status especially in children. Unlike serum zinc, conc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02115-w
更新日期:2020-08-01 00:00:00
abstract::The glutathione transferase (GST) activity of rat liver cytosolic preparations with ethacrynic acid (EA) and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydro-benzo(a)pyrene (BPDE) as substrates, increased by 125 and 350%, respectively, in animals that had been treated with a single intraveno...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917265
更新日期:1989-07-01 00:00:00
abstract::Selenium (Se) is an essential trace element in animals and human, however, excess Se intake can result in adverse health effects. Se supplementation increased glutathione peroxidase (GSH-Px) and thioredoxin reductase (TR) expressions in Se-deficient rats. However, little information is available on the relationship be...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:89:2:165
更新日期:2002-11-01 00:00:00
abstract::The degree of chromosome damage induced by three compounds of zinc (zinc chloride, zinc sulfate, zinc acetate) was compared in human leucocytes in vitro. Three concentrations of each salt, 3.0 x 10(-5)M, 3.0 x 10(-4)M, and 1.5 x 10(-3)M, were added to leukocyte cultures. The cells were harvested after 48 and 72 h and ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:78:1-3:113
更新日期:2000-01-01 00:00:00
abstract::We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 m...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02789076
更新日期:1995-04-01 00:00:00
abstract::There have been few investigations of trace elements in the urine and hair of populations exposed to high levels of arsenic (As) in drinking water. Therefore, concentrations of selected metals in urine and hair samples from a population in a study area where arsenism was endemic and a control area were determined. It ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1108-x
更新日期:2018-04-01 00:00:00
abstract::A microcomputer-controlled irradiation and measurement system and a microprocessor-controlled sample changer have been installed at the SLOWPOKE-2 Facility at the Royal Military College of Canada (RMC). These systems can provide the gamut of instrumental neutron activation analysis (INAA) techniques for the analyst. C...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992658
更新日期:1990-07-01 00:00:00
abstract::This study aimed to determine the relationship between the metabolic and endocrinological pathologies in polycystic ovary syndrome (PCOS) and the levels of arsenic, chromium, cadmium, lead, mercury, antimony, zinc, and copper to evaluate the relationship of these toxic metals with inflammatory/oxidative parameters. Th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02220-w
更新日期:2020-11-01 00:00:00
abstract::Cadmium (Cd) is a kind of toxic heavy metal and it can cause damage to organs and tissues. Selenium (Se) can antagonize some metal element toxicity including Cd. The present study was designed to investigate Cd-induced damage to chicken ovary by autophagy and the protective mechanism of Se on Cd-induced damage. Admini...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1341-y
更新日期:2018-12-01 00:00:00
abstract::Lack of specific markers constitutes a problem during diagnosis of headache syndromes. Recently, some metals have gained importance as biological parameters for the diagnosis and during treatment. Low-ionized Mg and high-ionized Ca/Mg in patients with daily migrainous headaches were noted. The blood Na level was shown...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1385/BTER:90:1-3:1
更新日期:2002-01-01 00:00:00
abstract::The objective was to evaluate metal ion accumulation in hair of patients undergoing orthodontic treatment with fixed appliances in time. The patients (N = 47) participated in a questionnaire survey. Hair sampling was performed at the beginning and in the 4th, 8th, and 12th month of the treatment. The content of metals...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-014-0152-z
更新日期:2015-02-01 00:00:00
abstract::Diabetic retinopathy (DR) is a common microvascular disorder which occurs in type 2 diabetes mellitus (T2DM) patients due to chronic hyperglycemia. Previous studies reported that serum zinc (Zn) and vitamin A levels were associated with certain diabetic microvascular complications. However, the relationship between Zn...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01664-z
更新日期:2019-12-01 00:00:00
abstract::Cadmium concentrations were determined in the hair of 226 school children in an industrial and in a rural area of Tarragona Province (NE Spain). The influence of sex, age, hair color, smoking habits of the household members, and parents' occupation on the children's hair cadmium levels was also evaluated. Children liv...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02863080
更新日期:1991-02-01 00:00:00
abstract::In this study, a method of positive matrix factorization (PMF) combined support vector machines (SVMs) was adopted to identify possible sources and apportion contributions for trace element pollution in surface sediments from the Jinjiang River, Southeastern China. Utilizing diagnostics tools, four significant factors...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9576-5
更新日期:2013-03-01 00:00:00
abstract::The concentrations of 17 elements in the nail and hair of 117 subjects from a nonindustrialized environment were determined by instrumental neutron activation analysis (INAA). A new method of statistical treatment that allows for more meaningful use of detection limit values was used to process the concentration data....
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795450
更新日期:1988-09-01 00:00:00
abstract::Quin2, a fluorescent calcium probe, has a low affinity for calcium in comparison to its affinities for transition metal ions. Chelation of ferric ion with quin2 strongly enhanced the formation of oxidizing species in the presence of bolus H2O2 as detected with four assays, electron spin resonance with the spin-trap DM...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790098
更新日期:1995-01-01 00:00:00
abstract::This study is aimed at investigating the inhibitory effect of cadmium ion on glutathione reductase activity of rabbit brain and liver and the relationship of this effect with dietary selenium. For this purpose, one group of New Zealand rabbits were fed a selenium-deficient diet, another group was fed a selenium-rich d...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:91:2:151
更新日期:2003-02-01 00:00:00
abstract::Stomatogenesis in ciliates is a complex and carefully orchestrated event. The exo- mutant SB255 of Tetrahymena thermophila has defects in mucocyst formation and docking and can also have one or two mouths. Three common culture media (proteose peptone, Medium 357, and yeast extract) were analyzed for total C, N, and in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785409
更新日期:1995-12-01 00:00:00
abstract::The trace elements antimony, bromine, cesium, cobalt, iron, rubidium, scandium, strontium and zinc were determined by instrumental neutron activation analysis in breast tissue samples with fibrocystic disease and in samples with fibroadenoma tumors. The histological lesions of each breast sample with fibrocystic disea...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917337
更新日期:1994-10-01 00:00:00
abstract::The developmental alterations in metallothionein (MT) proteins and zinc (Zn) were investigated in brains of two transgenic strains of mice. MT protein was measured by a cadmium binding assay and Zn by atomic absorption spectrophotometry. MT proteins were expressed at birth (day 1) both in MT-I overexpressing transgeni...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784039
更新日期:1998-01-01 00:00:00
abstract::A dose-response experiment was conducted to find the sensitive and consistent biomarker for the estimation of dietary manganese (Mn) requirement and establish the optimal Mn level for broilers fed a practical corn-soybean meal diet from 1 to 21 days of age post-hatching. A total of 480 1-day-old Arbor Acres male chick...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8931-7
更新日期:2011-11-01 00:00:00