Abstract：
:Diabetic retinopathy (DR) is a common microvascular disorder which occurs in type 2 diabetes mellitus (T2DM) patients due to chronic hyperglycemia. Previous studies reported that serum zinc (Zn) and vitamin A levels were associated with certain diabetic microvascular complications. However, the relationship between Zn and vitamin A levels with the severity of DR in type 2 diabetic patients is not clear. We aimed to analyze the relationship between serum Zn and vitamin A levels with the severity of DR in T2DM. Sixty T2DM patients were selected from whom attending to the ophthalmology center of hospital from June 2017 and Feb 2018. Patients were categorized as controls, non-proliferative DR (NPDR), and proliferative DR (PDR). Anthropometric, dietary, and physical activity data were gathered. Fasting blood samples were taken to measure biochemical parameters. Serum Zn and vitamin A levels were measured via enzymatic-calorimetric and HPLC methods, respectively. Results showed that serum Zn and vitamin A levels were significantly lower in the PDR group than the controls (p = 0.03 and p = 0.008, respectively). Serum low-density lipoprotein (LDL.C) was significantly higher in the PDR than the control group (p = 0.02). Adjusting for the other variables, increase in serum Zn and vitamin A levels reduced risk of DR by 25.7% and 31.1%, respectively (p = 0.02 and p = 0.007). Higher serum LDL.C increased DR severity by 28.7%, adjusted for the variables (95% CI = 0.002, 0.02; p = 0.01). Lower serum Zn and vitamin A levels, as well as higher LDL.C in the T2DM patients, are related to DR severity.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Rostamkhani H,Mellati AA,Tabaei BS,Alavi M,Mousavi SNdoi
10.1007/s12011-019-01664-zsubject
Has Abstractpub_date
2019-12-01 00:00:00pages
123-128issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-019-01664-zjournal_volume
192pub_type
杂志文章abstract：:Rare earth elements (REEs) have been widely used to increase accumulation of biomass and secondary metabolites in medicinal plants in China. However, very few studies have investigated how REEs mediate secondary metabolism synthesis in medicinal plants. Lanthanum (La), an important REE, is known to improve the accumul...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9379-8
更新日期：2012-09-01 00:00:00
abstract：:The effect of parenteral zinc on tissue metallothionein (MT) was studied in normal and streptozotocin-induced diabetic rats. The accumulation of Zn-MT in liver and pancreas of normal and diabetic rats following the administration (ip) of various amounts of zinc was not different. Renal Zn-MT was higher in the diabetic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795531
更新日期：1986-12-01 00:00:00
abstract：:Intraperitoneal administration of zinc chloride (ZnCl2) to Swiss albino mice in vivo induced a significant (p less than or equal to 0.05) increase in the frequencies of chromosomal aberrations of the bone-marrow cells at all concentrations used following acute (7.5, 10, 15 mg/kg body weight) and chronic (2.0, 3.0 mg/k...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990346
更新日期：1991-08-01 00:00:00
abstract：:The present study was undertaken to evaluate the in vitro availability of chemically varying forms of selenium (Se), supplemented in cow's milk. Two inorganic (selenite and selenate) and two organic (seleno-methionine [Se-Met] and seleno-cystine [Se-Cys]) Se sources were evaluated. The in vitro availability was estima...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02910666
更新日期：1997-07-01 00:00:00
abstract：:Selenium deficiency is known to cause cardiovascular diseases. However, the role of Se deficiency in causing oxidative damage and inflammation injury to the aorta vessels of chickens is not well known. In the present study, 180 1-day-old chickens were randomly divided into two groups, a low-Se group (L group) and a co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0676-5
更新日期：2016-10-01 00:00:00
abstract：:A 10-year-old Gir bullock was presented with four contiguous hard nodular submucosal masses attached to the right rostral mandible. Overgrown masses were resected surgically and submitted for microstructural, elemental, and molecular spectroscopic analyses. An osteoma was diagnosed histopathologically. Elemental analy...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-021-02604-6
更新日期：2021-01-26 00:00:00
abstract：:Among the trace elements, zinc is one of the most used elements in biological systems. Zinc is found in the structure of more than 2700 enzymes, including hydrolases, transferases, oxyreductases, ligases, isomerases, and lyases. Not surprisingly, it is present in almost all body cells. Preserving the stability and int...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-017-1119-7
更新日期：2018-05-01 00:00:00
abstract：:This study aims to reduce embryonic mortality, increase body weight, and improve immune system in chicken. A total of 240 eggs were assigned to three treatments (n = 60) and injected with cooper (Cu), zinc (Zn), and iron (Fe) loaded by montmorillonite (Mnt), and one untreated group (n = 60). Some hormones and enzymes ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02488-y
更新日期：2020-11-13 00:00:00
abstract：:Selenium (Se) is an essential trace element in animals and human, however, excess Se intake can result in adverse health effects. Se supplementation increased glutathione peroxidase (GSH-Px) and thioredoxin reductase (TR) expressions in Se-deficient rats. However, little information is available on the relationship be...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:89:2:165
更新日期：2002-11-01 00:00:00
abstract：:There are several factors that affected calcium bioavailability, such as physiological and dietary factors. These dietary factors help to achieve an appropiate status of calcium for a correct bone mineralization. In this pathway, recently some compounds present in milk that seem improve calcium absorption such as lact...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:89:1:43
更新日期：2002-10-01 00:00:00
abstract：:Guizhou black goats are essential to the production system in the Wumeng prairie in the Western China. This study aimed to determine the influence of nano-copper on antioxidant system in copper-deprived Guizhou black goats. We analyzed mineral contents in soil, forage, and goats' tissues. Blood parameters were also de...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02342-1
更新日期：2020-08-18 00:00:00
abstract：:Exposure to mobile phone-induced electromagnetic radiation (EMR) may affect biological systems by increasing free oxygen radicals, apoptosis, and mitochondrial depolarization levels although selenium may modulate the values in cancer. The present study was designed to investigate the effects of 900 MHz radiation on th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0032-6
更新日期：2014-08-01 00:00:00
abstract：:In this study, the induction of metallothionein (MT) in one species of oyster Ostrea edulis exposed to copper (Cu) and zinc (Zn) was examined. The quantity of total protein (mg protein/mg dry wt) in each sample and the measurement of MT were determined by the Lowry and silver (Ag)-saturation methods. Our results show ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784547
更新日期：1996-07-01 00:00:00
abstract：:Chromium (Cr), manganese (Mn), copper (Cu), zinc (Zn), and iron (Fe) concentrations were quantified in serum (n = 112), milk (n = 112), liver (n = 70), and kidney samples (n = 67) of dairy cows from an iron-steel processing region (Payas-Iskenderun) and from an area free of industrial pollution (Antakya) in Hatay, loc...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:98:1:51
更新日期：2004-04-01 00:00:00
abstract：:The effect of certain inorganic and coordinated nickel compounds on the resistance to different destructive substances, rheological properties, and functional activity of healthy human red blood cells (RBC), was investigated. It is shown that nickel compounds affect the erythrocyte membrane lipid bilayer, as well as m...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917273
更新日期：1989-07-01 00:00:00
abstract：:To elucidate compositional changes of the mitral valve with aging, the authors investigated the relationships among element contents in the mitral valves. The subjects consisted of 10 men and 15 women, ranging in age from 65 to 102 yr. After the ordinary dissection, mitral valves, lower parts of the interventricular s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:88:3:203
更新日期：2002-09-01 00:00:00
abstract：:Selenium was added to the feed of White Leghorn type chickens 1 day prior to challenge with either Escherichia coli or sheep erythrocyte antigen. The incidence of death or lesions was reduced from 86% to 21% at the optimal dose of selenium (0.4 mg/kg resulting in feed concentration of 0.45 mg/kg). After the chickens w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917469
更新日期：1997-09-01 00:00:00
abstract：:We investigated the rooting rate, the number of roots, and the state of growth of loquat (Eriobotrya japonica Lindi) plantlet in medium where La(NO3)3 (0.5-100.0 micromol/L) was added 20 d after transplanting. The activity of peroxidase, nitrate reductase, and the fresh weight of roots were determined 44 d after trans...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:89:3:277
更新日期：2002-12-01 00:00:00
abstract：:Thirty rats were divided randomly into five groups and fed with different feeds. They were killed after 2 mo. Right thighs of these rats were taken as samples. Bone mineral densities of these samples were measured by the double-energy x-ray bone mineral densitometer, and trace elements contents of the samples were ana...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784252
更新日期：1999-01-01 00:00:00
abstract：:The present study was designed to investigate the effects of montmorillonite (MMT) on dietary Cd-induced oxidative damage in liver and kidney of carp (Carassius auratus). One hundred eighty carp were randomly divided into four groups and fed with a basal diet, a basal diet supplemented with 0.5% MMT, Cd-comtaminated b...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8735-9
更新日期：2011-06-01 00:00:00
abstract：:The nuclear microscope is now gaining popularity in the field of life sciences. In particular, the combination of proton-induced X-ray emission to measure the elemental concentrations of inorganic elements, Rutherford backscattering spectrometry to characterize the organic matrix, and scanning transmission ion microsc...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02784192
更新日期：1999-01-01 00:00:00
abstract：:Supplementation with selenium is common for dairy cows, but the importance of selenium source is not clear. This study aimed to compare nano-selenium (Nano-Se) and sodium selenite supplements for dairy cows on lactation performance, milk Se levels and selenoprotein (Sel) gene expression. Twelve multiparous Holstein co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02139-2
更新日期：2021-01-01 00:00:00
abstract：:Lanthanum cations (La 3+) are well known for their inhibitory actions on calcium channels. Prenatal lanthanum exposure may affect the development of embryo and alter the capacity for learning and memory in adults, and the one-trial passive avoidance learning paradigm with day-old chicks is an excellent model to study ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8225-5
更新日期：2009-01-01 00:00:00
abstract：:Prostate cancer is one of the most common cancers and the second cause of cancer-related deaths among men. Metals are recognized as chemical carcinogens where chronic exposures to such metals are implicated in the development of cancer, including prostate cancer. This in vitro study demonstrates the relative death sen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0100-y
更新日期：2014-12-01 00:00:00
abstract：:Multielemental detection using Instrumental Neutron Activation Analysis (INAA) and Proton-Induced X-Ray Emission (PIXE) of drinkable water of Florence (Italy) is described. The concentrations of 52 elements were measured. No chemical treatment was performed on the samples, before or after irradiation. On the basis of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992691
更新日期：1990-07-01 00:00:00
abstract：:The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, so...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:80:1:53
更新日期：2001-04-01 00:00:00
abstract：:Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:80:3:251
更新日期：2001-06-01 00:00:00
abstract：:Both manganese and copper may affect bone synthesis. Bone content of both metals can be altered in alcoholics, although controversy exists regarding this matter. To analyse the relative and combined effects of ethanol and a low protein diet on bone copper and manganese, and their relationships with bone structure and ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9296-2
更新日期：2012-06-01 00:00:00
abstract：:The aim of this study was to evaluate the impact of three different chromium forms as chromic chloride (CrCl), chromium picolinate (CrPic), and a newly synthesized complex of chromium chelated with small peptides (CrSP) on glucose uptake and metabolism in vitro. In cultured skeletal muscle cells, chromium augmented in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8357-2
更新日期：2009-11-01 00:00:00
abstract：:The use of phosphate fertilizers is essential in agriculture, because they supply farmland with nutrients for growing plants. However, heavy metals might be included as impurities in natural materials and minerals, so heavy metals can also be present in phosphate fertilizers or other chemical fertilizers. The aim of t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9161-3
更新日期：2012-01-01 00:00:00
