Abstract:
:Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells simultaneously treated with selenite or selenomethionine and 3.5 microM MMC showed a decreased mercury concentration with increased selenium dose especially seen in the selenite combinations. The simultaneous selenite and MMC 3.5 microM combinations showed growth curves with an increasing number of viable cells with increased selenite dose. All combinations with 5 microM MMC were toxic to the cells. Interactions between selenite or selenomethionine and MMC regarding cellular uptake of mercury and selenium were observed and indications of selenite protection against MMC toxicity in human K-562 cells were noticed.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Frisk P,Yaqob A,Nilsson K,Lindh Udoi
10.1385/BTER:80:3:251subject
Has Abstractpub_date
2001-06-01 00:00:00pages
251-68issue
3eissn
0163-4984issn
1559-0720pii
BTER:80:3:251journal_volume
80pub_type
杂志文章abstract::Selenium is a trace element that, although toxic in higher concentrations, is essential for human and animal health. In this study, we looked at microarray-based gene expression patterns from liver and gastrocnemius tissues in mice fed either a selenium-deficient diet or diets containing sodium selenite, selenomethion...
journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
abstract::Selenium (Se) deficiency in the experimental models, Coturnix coturnix japonica and Corcyra cephalonica, resulted in impaired mitochondrial substrate oxidations and lowered thiol levels. Studies with respiratory inhibitors confirmed reduced mitochondrial electron transport enzyme activities, especially at cytochrome c...
journal_title:Biological trace element research
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更新日期:1996-03-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
abstract::In this study, the induction of metallothionein (MT) in one species of oyster Ostrea edulis exposed to copper (Cu) and zinc (Zn) was examined. The quantity of total protein (mg protein/mg dry wt) in each sample and the measurement of MT were determined by the Lowry and silver (Ag)-saturation methods. Our results show ...
journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:1996-07-01 00:00:00
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更新日期:2018-10-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00
abstract::The toxic effect of Pb2+ has been studied in eukaryotic cells by using Tetrahymena as a target. The maximum power (P(m)) and the growth rate constant (k) were determined, which showed that values of P(m) and k were linked to the concentration (C) of Pb2+. The addition of Pb2+ caused a decrease of the maximum heat prod...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-0055-3
更新日期:2007-11-01 00:00:00
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更新日期:2006-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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更新日期:2017-12-01 00:00:00
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更新日期:1994-06-01 00:00:00
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abstract::Platelet-rich fibrin (PRF) is widely used blood-derived biomaterial which is directly applied to the surgical wounds. Depending on its autologous origin, PRF is thought as a safe material. However, it is not known to what extent the blood-derived toxins can be found in the PRF by considering the systemic exposure rate...
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journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
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更新日期:2012-12-01 00:00:00
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更新日期:2008-01-01 00:00:00
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更新日期:2012-11-01 00:00:00
abstract::Trace minerals and vitamins are known modulators of bone metabolism, and dietary optimization of these components may improve skeletal development and reduce the occurrence of skeleton deformities in farmed fish. As for larval stages, mineral and water-soluble vitamin nutrition requirements are lacking in research eff...
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pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00