Abstract：
:Osteoporosis is a bone disease that leads to an increased risk of fracture. Oxidative stress may play a major role in the development of osteoporosis in part by inhibiting osteoblastic differentiation of bone marrow stromal cells (MSCs). Some evidence suggested that antioxidant selenium could prevent osteoporosis, but the underlying mechanism remains unclear. In this work, the effect of sodium selenite on H₂O₂-induced inhibition of osteoblastic differentiation of primary rat bone MSCs and the related mechanisms were examined. Pretreatment with selenite inhibited the adverse effect of H₂O₂ on osteoblastic differentiation of MSCs, based on alkaline phosphatase activity, gene expression of type I collagen and osteocalcin, and matrix mineralization. In addition, selenite pretreatment also suppressed the activation of extracellular signal-regulated kinase (ERK) induced by H₂O₂. The above effects were mediated by the antioxidant effect of selenite. Selenite enhanced the gene expression and activity of glutathione peroxidase, reversed the decreased total antioxidant capacity and reduced glutathione, and suppressed reactive oxygen species production and lipid peroxidation level in H₂O₂-treated MSCs. These results showed that selenite protected MSCs against H₂O₂-induced inhibition of osteoblastic differentiation through inhibiting oxidative stress and ERK activation, which provided, for the first time, the mechanistic explanation for the negative association of selenium status and risk of osteoporosis in terms of bone formation.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Liu H,Bian W,Liu S,Huang Kdoi
10.1007/s12011-012-9488-4subject
Has Abstractpub_date
2012-12-01 00:00:00pages
441-50issue
1-3eissn
0163-4984issn
1559-0720journal_volume
150pub_type
杂志文章abstract：:The purpose of this study was to determine the dietary essentiality of lithium (Li) in rats. In three experiments, two types of diets were fed during growth, reproduction, and lactation. In the first experiment, dams were maintained on a corn-based diet containing 2 ng or 500 ng (controls) Li/g through five successive...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783685
更新日期：1992-09-01 00:00:00
abstract：:Metallic tin powder injected into Lewis rats caused marked enlargement of draining lymph nodes with prominent hyperplasia of plasma cells. A low level of dietary protein (8%) or deficiency of choline interfered with the cellular proliferation and reduced the size of the nodes by nearly one-third compared to a normal p...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:85:1:71
更新日期：2002-01-01 00:00:00
abstract：:This study evaluated the plasma levels of trace elements in children with chronic hepatitis B virus (HBV) infection and assessed whether they can be a factor that affects the response to interferon alpha (IFN-alpha) treatment. The study included 35 cases (ten girls, 25 boys) aged 3-13 years with chronic HBV infection ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8507-6
更新日期：2010-06-01 00:00:00
abstract：:Rare earth elements can promote photosynthesis, but their mechanisms are still poorly understood under magnesium deficiency. The present study was designed to determine the role of cerium in magnesium-deficient maize plants. Maize was cultivated in Hoagland's solution added with cerium with and without adequate quanti...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8769-z
更新日期：2011-09-01 00:00:00
abstract：:Divalent metal ions (Fe2+, Cu2+, Zn2+, Ni2+, and Mn2+) induced lipid oxidation in cooked, but not in raw fish. The extent of lipid oxidation, measured by the production of thiobarbituric acid reactive substances (TBRS), was increased with higher concentrations of iron, zinc, and nickel, but was decreased with increasi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783896
更新日期：1992-07-01 00:00:00
abstract：:In vivo and in vitro studies were conducted to investigate the chemical forms by ion-exchange chromatography of selenium (Se) present in rat and ovine spermatozoa. After injection with 75Se-selenite, the form of 75Se in rat sperm was selenocysteine, but selenocysteine and selenomethionine (SeMet) were present in ovine...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:76:2:161
更新日期：2000-08-01 00:00:00
abstract：:Iron and copper are essential microminerals that are intimately related. The present study was performed to determine the effect of iron-deficiency anemia (IDA) and treatment with iron on laboratory indicators of copper status. Hemoglobin, mean corpuscular volume erythrocyte Zn protoporphyrin, serum ferritin, serum co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:112:3:213
更新日期：2006-09-01 00:00:00
abstract：:The biological function of selenium (Se) is mainly elicited through Se-containing proteins. Selenoprotein W (SelW), one member of the selenoprotein family, is essential for the normal function of the skeletal muscle system. To investigate the possible relationship of Se in the process of differentiation in chicken myo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9520-8
更新日期：2012-12-01 00:00:00
abstract：:The objective of this study was to investigate the iron source absorption in the small intestine of broiler. In situ ligated intestinal loops of 70 birds were poured into one of seven solutions, including inorganic iron (FeSO4, Fe2(SO4)3), organic Fe glycine chelate (Fe-Gly(II), Fe-Gly(III)), the mixtures (FeSO4 with ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0179-1
更新日期：2015-02-01 00:00:00
abstract：:The present study was designed to investigate the effects of montmorillonite (MMT) on dietary Cd-induced oxidative damage in liver and kidney of carp (Carassius auratus). One hundred eighty carp were randomly divided into four groups and fed with a basal diet, a basal diet supplemented with 0.5% MMT, Cd-comtaminated b...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8735-9
更新日期：2011-06-01 00:00:00
abstract：:A survey of mercury (Hg) and selenium (Se) contents was performed in fish collected from lakes located in two National Parks of the northern patagonian Andean range. Two native species, catfish (Diplomystes viedmensis) and creole perch (Percichthys trucha), and three introduced species, brown trout (Salmo trutta), rai...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-8059-6
更新日期：2008-04-01 00:00:00
abstract：:The aim of the present study was to investigate the effect of selenium (Se) deficiency on the expression of the toll-like receptor (TLR) signal transduction pathway in the spleen of chickens and explore the relationship between the TLR4/TRIF/NF-κB signaling pathway and inflammatory spleen injury. A total of 200 one-da...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02173-0
更新日期：2021-02-01 00:00:00
abstract：:Multielemental detection using Instrumental Neutron Activation Analysis (INAA) and Proton-Induced X-Ray Emission (PIXE) of drinkable water of Florence (Italy) is described. The concentrations of 52 elements were measured. No chemical treatment was performed on the samples, before or after irradiation. On the basis of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992691
更新日期：1990-07-01 00:00:00
abstract：:Although lead is known to induce arterial hypertension and vascular damage, it is not clear if after cessation of lead treatment, the increase of blood pressure is sustained and the vascular function is different from untreated rats. Therefore, we aimed to evaluate the systolic blood pressure during and following lead...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0497-y
更新日期：2016-04-01 00:00:00
abstract：:Nickel (Ni) has not been elucidated as an essential mineral in dairy animals, though in plants and lower organisms, its role in activation of urease enzyme is well known. This study was conducted to evaluate the effect of Ni supplementation on intake, growth performance, urease activity, antioxidant and immune status,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1524-6
更新日期：2019-07-01 00:00:00
abstract：:Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.(109)Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common tr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785356
更新日期：1980-09-01 00:00:00
abstract：:This study is aimed at investigating the inhibitory effect of cadmium ion on glutathione reductase activity of rabbit brain and liver and the relationship of this effect with dietary selenium. For this purpose, one group of New Zealand rabbits were fed a selenium-deficient diet, another group was fed a selenium-rich d...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:91:2:151
更新日期：2003-02-01 00:00:00
abstract：:Previous studies have shown that there is a controversial relationship between iron homeostasis and obesity. This study aims to explore the relationship of anemia and iron status with different body size phenotypes in adult Chinese population. Using information on iron status-related parameters and lifestyle data from...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1213-x
更新日期：2018-09-01 00:00:00
abstract：:Recently, several attempts have been made to use the phytopharmaceuticals from plant extracts as reducing, capping and stabilizing agents for the biomimetic synthesis of various metal nanoparticles conjugated to the phytopharmaceuticals. These biogenic metal nanoparticles are non-toxic and can be used as contrast agen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1287-0
更新日期：2018-11-01 00:00:00
abstract：:The objective of the present study was to investigate the relationship between hair essential trace element and mineral content and ADHD in preschool (4-6 years old) and primary school children (6-10 years old) in relation to age and gender. Hair essential trace element and mineral content in 90 Russian children with ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01947-5
更新日期：2020-08-01 00:00:00
abstract：:Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA us...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02468-2
更新日期：2020-11-05 00:00:00
abstract：:Indigenous preparations (IPs) have evoked a considerable interest in alleviating infections and chronic diseases and improving wellbeing. While such formulations have been a part of traditional practice in several countries and many have been reviewed scientifically for their claims, several of them until date remain ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1411-1
更新日期：2019-04-01 00:00:00
abstract：:We investigated the rooting rate, the number of roots, and the state of growth of loquat (Eriobotrya japonica Lindi) plantlet in medium where La(NO3)3 (0.5-100.0 micromol/L) was added 20 d after transplanting. The activity of peroxidase, nitrate reductase, and the fresh weight of roots were determined 44 d after trans...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:89:3:277
更新日期：2002-12-01 00:00:00
abstract：:The effects of nutritional copper deficiency on carrageenin edema in the rat were investigated with emphasis on studying the correlation between the degree of copper deficiency and the degree of edema. Carrageenin paw edema in both copper-sufficient and copper-deficient groups of rats was compared after either 20, 40,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917181
更新日期：1989-01-01 00:00:00
abstract：:The binding of selenite, the form of selenium used in the treatment of Keshan disease, to plasma proteins and the role of erythrocytes in this process have been studied. The experiments were carried out by incubating 75Se as selenite with plasma and whole blood in vitro (human and rat) and in vivo (rat) and subsequent...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990129
更新日期：1988-01-01 00:00:00
abstract：:The key role of osteoblasts in skeletal fluorosis makes the exploration of the possible mechanisms of the fluoride-induced oxidative stress of osteoblasts of great importance. In this article, the in vitro effects of fluoride on the oxidative stress of osteoblasts are presented. To study the inhibitory effect of baica...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02685921
更新日期：2007-04-01 00:00:00
abstract：:In this study, experimental hyperthyroidism was established and used to investigate possible alterations in the calcium (Ca), magnesium (Mg), and zinc (Zn) homeostasis by assessing their concentrations in plasma and erythrocytes. In the L-thyroxine-induced hyperthyroidism condition, the experimental animals show a sig...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02778196
更新日期：1997-05-01 00:00:00
abstract：:The effects of 10 wk of selenium (Se) supplementation (5 ppm) in drinking water on immune responses and resistance to a myocarditic Coxsackie virus B3 (CB3) infection were studied in female Balb/c mice. Se supplementation reduced CB3-induced mortality: at day 14 postinoculation, survival was 58% in the Se-treated grou...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785277
更新日期：1998-07-01 00:00:00
abstract：:Trace elemental content was analysed in edible tissues of Mytilus galloprovincialis collected in five different sampling areas near the mouth of river Tagus estuary in Lisbon. The concentrations of essential elements (S, K, Ca, Fe, Cu, Zn, As, Br and Sr) were determined by energy-dispersive X-ray fluorescence (EDXRF) ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9974-y
更新日期：2014-06-01 00:00:00
abstract：:In this experimental study, the effect of cadmium on cold and restraint stress-induced gastric lesions has been studied. Rats received 15 micrograms/mL cadmium-containing water for 30 d, and at the end of this period, they were subjected to cold and restraint stress. Cadmium accumulation in gastric mucosa was associat...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02790120
更新日期：1995-01-01 00:00:00
