Abstract:
:Although lead is known to induce arterial hypertension and vascular damage, it is not clear if after cessation of lead treatment, the increase of blood pressure is sustained and the vascular function is different from untreated rats. Therefore, we aimed to evaluate the systolic blood pressure during and following lead-treatment discontinuance and the possible vascular alterations involved with it. Rats received lead acetate (100 mg/L) in the drinking water or distilled water for 14 days. After 14 days, lead acetate solution was substituted by water distilled for more 28 days, as control group. Systolic blood pressure (SBP) was measured weekly by tail plethysmography, and the vascular reactivity to phenylephrine in isolated aortic rings was evaluated at end of treatment time. The increase in SBP induced by lead was reversed after stopping exposure, and it was accompanied by a reduction on vasoconstrictor response to phenylephrine. L-NAME treatment increased the phenylephrine response in both groups, but its effect was greater in lead group. Our findings provide evidence that the increased modulation by NO on contractile response to phenylephrine could be a compensatory mechanism that might contribute to decrease blood pressure after lead treatment cessation.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Broseghini-Filho GB,Almenara CC,Vassallo DV,Padilha ASdoi
10.1007/s12011-015-0497-ysubject
Has Abstractpub_date
2016-04-01 00:00:00pages
410-4issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-015-0497-yjournal_volume
170pub_type
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