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Effects of Nickel Supplementation on Antioxidant Status, Immune Characteristics, and Energy and Lipid Metabolism in Growing Cattle.

Abstract：

:Nickel (Ni) has not been elucidated as an essential mineral in dairy animals, though in plants and lower organisms, its role in activation of urease enzyme is well known. This study was conducted to evaluate the effect of Ni supplementation on intake, growth performance, urease activity, antioxidant and immune status, and energy and lipid metabolism in growing cattle. Eighteen growing Hariana heifers were randomly allocated into three groups on body weight (125 ± 3.0 kg) and age basis (10 ± 2.0 months). Feeding regimen was similar in all the groups except that treatment groups were supplemented with 0.0 (Ni0.0), 1.5 (Ni1.5), and 3.0 (Ni3.0) mg of Ni/kg dry matter (DM) in three respective groups. DM intake (DMI), average daily gain (ADG), feed efficiency, plasma urease activity, biomarkers of antioxidant and immune status, energy and lipid metabolism, and plasma Ni levels were observed during the 90-day experimental period. There was linear increase (p < 0.05) in mean DMI and ADG without affecting feed efficiency was observed in 3.0 mg of Ni/kg DM supplemented heifers. Dietary Ni supplementation showed linear increase (p < 0.05) in mean plasma urease activity. No effects of (p > 0.05) of Ni supplementation were observed on superoxide dismutase (SOD) and catalase (CAT) activity and plasma lipid peroxide (LPO) concentration; whereas, mean plasma total antioxidant status (TAS) showed linear decrease (p < 0.001) in Ni-supplemented groups. Adding Ni up to 3.0 mg of Ni/kg DM did not exert (p > 0.05) any effect on plasma total immunoglobulin and immunoglobulin G (IgG) concentrations. Mean plasma cortisol level showed negative association with supplemental Ni levels and concentration was found lowest (p < 0.05) in 3.0 mg of Ni/kg DM-added group. Dietary Ni supplementation did not affect mean plasma concentrations of glucose, cholesterol, triglyceride, and non-esterified fatty acids (NEFA). There was a linear increase (p < 0.001) in plasma Ni concentrations as the Ni concentrations increased in the diet. The results of present study indicated that dietary supplementation of 3.0 mg of Ni/kg DM improved performance of growing cattle by increasing urease activity.

journal_name

Biol Trace Elem Res

journal_title

Biological trace element research

authors

Singh A,Kumar M,Kumar V,Roy D,Kushwaha R,Vaswani S,Kumar A

doi

10.1007/s12011-018-1524-6

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

65-75

issue

eissn

0163-4984

issn

1559-0720

pii

10.1007/s12011-018-1524-6

journal_volume

190

pub_type

杂志文章

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Effects of Nickel Supplementation on Antioxidant Status, Immune Characteristics, and Energy and Lipid Metabolism in Growing Cattle.