Abstract:
:Biological half-lives of bromine in 15 different organs and tissues of the rat, in addition to the whole-body half-life, were determined by measuring the radioactive concentration of 82Br-bromide in samples of tissues collected at the time intervals of 12-396 h from animals that continuously (up to 17 d) received 82Br-labeled bromide in their drinking water. The half-life values, calculated from the experimental data by the method of gradual estimates of the parameters in question with the SPSS statistical program, ranged from 94.3+/-14.6 h in the thyroid gland to 235.0+/-88.9 h in liver. In most of the studied tissues, the biological half-lives of bromine were shorter than in the whole body, in which it equaled 197.8+/-22.2 h. Significant correlation between the values of the steady-state concentration of bromide and of the biological half-life was found for most tissues (except for liver). The steady-state concentrations of 82Br in tissues are probably proportional to the magnitude of bromide space, and, consequently, of chloride space.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Pavelka S,Babický A,Vobecký M,Lener J,Svandová Edoi
10.1385/BTER:76:1:57subject
Has Abstractpub_date
2000-07-01 00:00:00pages
57-66issue
1eissn
0163-4984issn
1559-0720pii
BTER:76:1:57journal_volume
76pub_type
杂志文章abstract::Nonenzymatic glycation of long-lived proteins has been implicated in several complications related to age and diabetes. Dicarbonyl compounds such as methylglyoxal (MGO) have been identified as the predominant source for the formation of advanced glycation end-products (AGEs) in various tissues. We investigated the eff...
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pub_type: 临床试验,杂志文章,随机对照试验
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