Interactions of mercury in rat brain.

Abstract:

:In order to study the metabolism of mercury (Hg), its affinity to metallothionein (MT), and its influence on levels of the essential metals copper and zinc in the brain tissue of rats exposed to elemental mercury (HgO) vapor was investigated. The major findings were: 1. After long-term exposure, about 40% of mercury was found in the brain water-soluble phase (supernatant); 2. In brain supernatant, about 80% of Hg was found in the range of low-molecular-weight proteins; the MT-like protein Hg-Cu-Zn-thionein was isolated and partially characterized; 3. HgO vapor exposure resulted in increased tissue levels of essential Cu and Zn in addition to exogenous Hg; and 4. Experiments showed that HgO vapor exposure can induce the stimulation of rat brain MT synthesis.

journal_name

Biol Trace Elem Res

authors

Falnoga I,Kregar I,Skreblin M,Tusek-Znidaric M,Stegnar P

doi

10.1007/BF02789402

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

71-83

issue

1

eissn

0163-4984

issn

1559-0720

journal_volume

37

pub_type

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