Abstract:
:The metabolism of 203Hg-labeled methylmercury chloride (MeHg) has been studied in rabbits and hamsters. Rabbits were administered 1.6 mumols MeHgCl/kg bw intravenously, and hamsters 40 mumols/kg bw orally. Urine and feces were collected daily and groups of four animals killed after 1 h, 1 d, or 7 d. The concentration of 203Hg in blood, liver, kidney, spleen, lung, heart, and brain was determined by gamma counting. In both animal species, the clearance of 203Hg in the brain was slower than in other tissues. In the rabbits the brain 203Hg concentration increased during the whole experimental period. Rabbits excreted 203Hg primarily in feces (about 20% of the dose within 1 wk), and much less in urine (less than 2%). In contrast, hamsters very efficiently excreted 203Hg in urine (50% in 1 wk). The fecal excretion was similar to that of the rabbits. Separation of inorganic Hg and MeHg in urine from hamsters by ion exchange chromatography showed that about 90% of the urinary 203Hg was excreted as MeHg. These findings show that rabbits and hamsters are interesting experimental animal systems for studying the metabolism of MeHg.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Petersson K,Dock L,Vahter Mdoi
10.1007/BF02917256subject
Has Abstractpub_date
1989-07-01 00:00:00pages
219-26eissn
0163-4984issn
1559-0720journal_volume
21pub_type
杂志文章abstract::This study was initiated to examine if variations in the concentrations of cadmium (Cd) and lead (Pb) in water environment may affect metal levels in local foods and body burden of local residents in non-polluted areas in Japan. Two nationwide databases have been made available on concentrations of Cd in locally harve...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8436-4
更新日期:2010-03-01 00:00:00
abstract::Addition of zinc lowers the toxicity level of cadmium in cultured CHO cells. Cell survival and protein synthesis were used to measure the cellular toxicity of cadmium.(109)Cd was used to measure cadmium uptake by the cells. The results suggest that these class IIB transition metals, zinc and cadmium, share a common tr...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785356
更新日期:1980-09-01 00:00:00
abstract::This study was designed to investigate the effects of chromium methionine (Cr-Met) on glucose metabolism, blood metabolites, meat lipid peroxidation, and tissue chromium (Cr) in Mahabadi goat kids. Thirty-two male kids (16.5 ± 2.8 kg BW, 4-5 months of age) were fed for 90 days in a completely randomized design with fo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0190-6
更新日期:2015-03-01 00:00:00
abstract::Selenium (Se) is an essential trace element in animals and human, however, excess Se intake can result in adverse health effects. Se supplementation increased glutathione peroxidase (GSH-Px) and thioredoxin reductase (TR) expressions in Se-deficient rats. However, little information is available on the relationship be...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:89:2:165
更新日期:2002-11-01 00:00:00
abstract::Cadmium (Cd) exposure has been recognized to result in a wide variety of cellular responses, including oxidative stress and body weight loss. The aim of the present study was to examine the effect of lycopene supplementation on the antioxidant defense system, lipid peroxidation (LPO) level, nitric oxide (NO), tumor ne...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-0027-7
更新日期:2007-08-01 00:00:00
abstract::The main aim of the study was to determine the role of cerium in the amelioration of calcium-deficiency effects in spinach plants. Spinach plants were cultivated in Hoagland's solution. They were subjected to calcium-deficiency and to cerium chloride administered in the calcium-present Hoagland's media and calcium-def...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8054-y
更新日期:2008-03-01 00:00:00
abstract::Iron and copper are essential microminerals that are intimately related. The present study was performed to determine the effect of iron-deficiency anemia (IDA) and treatment with iron on laboratory indicators of copper status. Hemoglobin, mean corpuscular volume erythrocyte Zn protoporphyrin, serum ferritin, serum co...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:112:3:213
更新日期:2006-09-01 00:00:00
abstract::Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7 +/- 12.2 micrograms/L; p < 0.01; n = 18) and stage III (47.6 +/- 11.3 microg...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02778982
更新日期:1997-01-01 00:00:00
abstract::The contribution of gamma-ray scattering to the total efficiency for point-source geometries in a gamma spectrometer was measured. Scattering of gamma-rays on the shield and in the sample was considered. For a 25% efficiency detector in a small shield, about a 1% contribution to the total efficiency was measured, wher...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917374
更新日期:1994-10-01 00:00:00
abstract::Copper is an integral part of many important enzymes involved in a number of vital biological processes. Even though it is essential to life, at elevated tissue concentrations, copper can become toxic to cells. Recent studies have reported oxidative damage due to copper in various tissues. Considering the vulnerabilit...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9320-1
更新日期:2012-06-01 00:00:00
abstract::Evidence shows an association between markers of iron metabolism and glucose metabolism in type 2 diabetes mellitus. Acute pancreatitis is the largest contributor to diabetes of the exocrine pancreas. However, the pathogenesis of new-onset pre-diabetes or diabetes after pancreatitis remains unclear. This study aimed t...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-017-1131-y
更新日期:2018-05-01 00:00:00
abstract::In 47 children with malignancy, zinc status, growth, and performance during standard treatment were compared with those in controls. At diagnosis, growth was retarded and hair zinc values were high, 2.4 +/- 0.7 mumol/g, as in chronic deficiency. During induction therapy, serum declined to 10.4 +/- 2.3 mumol/L and urin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02991414
更新日期:1991-09-01 00:00:00
abstract::Selenium was added to the feed of White Leghorn type chickens 1 day prior to challenge with either Escherichia coli or sheep erythrocyte antigen. The incidence of death or lesions was reduced from 86% to 21% at the optimal dose of selenium (0.4 mg/kg resulting in feed concentration of 0.45 mg/kg). After the chickens w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917469
更新日期:1997-09-01 00:00:00
abstract::Instrumental epithermal neutron activation analysis was used in determining the halide concentration of camel serum. The halides determined were sodium, chloride, bromide, and iodide. Serum was examined when the camels had free access to drinking water, following 10 d of water restriction and 2 h following rapid rehyd...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796697
更新日期:1987-04-01 00:00:00
abstract::The kidney has been regarded as a critical organ of toxicity induced by acute exposure to hexavalent chromium [Cr(VI)] compounds. Reactive intermediates and free radicals generated during reduction process might be responsible for Cr(VI) toxicity. In this study, the effects of pretreatment or posttreatment of taurine ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:102:1-3:209
更新日期:2004-01-01 00:00:00
abstract::The purpose of this study was to determine the dietary essentiality of lithium (Li) in rats. In three experiments, two types of diets were fed during growth, reproduction, and lactation. In the first experiment, dams were maintained on a corn-based diet containing 2 ng or 500 ng (controls) Li/g through five successive...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783685
更新日期:1992-09-01 00:00:00
abstract::In the present study, 15 different commercial tea brands sold in Khyber Pakhtunkhwa were collected from the markets. The samples were analyzed for the concentrations of ten selected heavy metals. The metal concentration showed a random distribution in all samples. The mean concentration of Cd, Cu, Mn, Pb, Zn, and Fe w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02059-1
更新日期:2020-11-01 00:00:00
abstract::The effect of maternal dietary selenium (Se) and gestation on the concentrations of Se and zinc (Zn) in the porcine fetus were determined. Mature gilts were randomly assigned to treatments of either adequate (0.39 ppm Se) or low (0.05 ppm Se) dietary Se. Gilts were bred and fetuses were collected throughout gestation....
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:97:1:57
更新日期:2004-01-01 00:00:00
abstract::We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 m...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02789076
更新日期:1995-04-01 00:00:00
abstract::Changes in the macro and trace element composition of saliva might be indicative for pathological changes in periodontal tissues. However, there is a lack of evidence in the literature showing associations between mineral elements and periodontal status. The aim of this study was to determine whether such associations...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01977-z
更新日期:2020-09-01 00:00:00
abstract::Studies investigating the effects of Chromium (Cr) supplementation on unstressed broiler chickens have reported an inconsistent association between Cr supplementation and broiler chickens' responses. We conducted a dose-response meta-analysis of previous studies to assess the dose-response associations between Cr supp...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-021-02589-2
更新日期:2021-01-17 00:00:00
abstract::Selenomethionine metabolism and the biochemical basis for its cytotoxicity were analyzed in cultured human and murine lymphoid cells. The metabolic pathways were also addressed, using purified mammalian enzymes and crude tissue extracts. Selenomethionine was found to be effectively metabolized to S-adenosylmethionine ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990463
更新日期:1991-01-01 00:00:00
abstract::Microbeam X-ray spectrometry, energy-dispersive X-ray fluorescence analysis, and neutron activation analysis were evaluated for the detection of selenium contained in the selenoprotein glutathione peroxidase. The glutathione peroxidase had been previously separated using polyacrylamide gel electrophoresis. The use of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917328
更新日期:1994-10-01 00:00:00
abstract::This study investigated whether boron would enhance the ability of 17beta-estradiol (E2) or parathyroid hormone (PTH) to improve bone quality in ovariectomized OVX rats. Adult OVX rats were treated for 5 wk with vehicle, boron (5 ppm as boric acid), E2 (30 microg/kg/d, sc), PTH (60 microg/kg/d, sc), or a combination o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:82:1-3:109
更新日期:2001-07-01 00:00:00
abstract::Calcium, magnesium, and zinc balances were determined in eleven young adult college females (mean age, 24.9±2.35) during a 39-d metabolic study when the subjects were fed an adequate calorie and protein diet based on habitually consumed foods. Analysis showed that the dietary contribution of calcium, magnesium, and zi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917454
更新日期:1985-11-01 00:00:00
abstract::Recently, considerable attention has been paid to the negative effects caused by the presence and constant increase in concentration of heavy metals in the environment, as well as to the determination of their content in human biological samples. In this paper, the concentration of chromium in samples of blood and int...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1328-8
更新日期:2018-12-01 00:00:00
abstract::The key role of osteoblasts in skeletal fluorosis makes the exploration of the possible mechanisms of the fluoride-induced oxidative stress of osteoblasts of great importance. In this article, the in vitro effects of fluoride on the oxidative stress of osteoblasts are presented. To study the inhibitory effect of baica...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02685921
更新日期:2007-04-01 00:00:00
abstract::The liver of Hooded Seal (Cystophora cristata) consists of six lobes of unequal sizes. Extensive sampling by means of cutout samples covering the depth horizon 2-30 mm below liver surface indicates that the liver may be considered homogeneous as to concentrations of zinc, cadmium, mercury, and selenium (residuals of o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789141
更新日期:1990-01-01 00:00:00
abstract::Deficiency of intracellular magnesium (icMg) may coexist with normal serum Mg levels. Little is known about clinical and pharmacological factors affecting icMg in normomagnesemic patients with diabetes mellitus (DM). Moreover, no information exists regarding the icMg state in diabetic patients after acute illness and ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8024-4
更新日期:2007-01-01 00:00:00
abstract::The effect of manganese (Mn) supplementation on bone mineral density (BMD) and bone metabolism parameters was determined in ovariectomized Sprague-Dawley rats. Rats were divided into four groups (OVX, OVX+Mn, sham, sham+Mn) and fed with different intake levels of manganese (adequate 0.001% Mn, supplementation 0.01% Mn...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8119-6
更新日期:2008-07-01 00:00:00