Abstract:
:The structure and bioactivity of Ginkgo biloba leaves polyprenol (GBP) are similar to that of dolichol which widely exists in human and mammalian organs. GBP possesses potential pharmacological activities against cancer. This study involved oil-in-water type nanoemulsion (NE) loading GBP was prepared by dissolving polyprenol in nanoemulsion of sodium tripolyphosphate (TPP)/TiO2 solution, Triton X-100, and 1-octanol by inversed-phase emulsification (EIP) and ultrasonic emulsification (UE) method. Folic acid (FA)-coupled chitosan (CS) nanoparticles (NPs), GBP-FA-CS-NPs and GBP-TiO2-FA-CS-NPs, were fabricated by ionic cross-linking of positively charged FA-CS conjugates and negatively charged nanoemulsion with TPP/TiO2. And characterizations of them were investigated by TEM, SEM, FTIR, particle size, and zeta potential. The cytotoxic and genotoxic effects of GBP-TiO2-FA-CS-NP treatment were higher than GBP-NE, GBP-FA-CS-NPs, TiO2-NE, GBP-TiO2-NE, TiO2-FA-CS-NPs, and GBP-TiO2-FA-CS-NP treatment at the same tested concentrations in HepG2 cells. GBP-TiO2-FA-CS-NPs at low TiO2 concentration (from 1 to 2.5 μg/ml) showed good inhibition capacity on HepG2 cells and low cytotoxic and genotoxic effects on HL-7702 cells. The possible mechanism of cytotoxicity on GBP-TiO2-FA-CS-NPs against HepG2 cells is by preventing excessive intracellular Ca2+ into extracellular spaces via inhibiting Ca2+-ATPase and Ca2+/Mg2+-ATPase.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Tao R,Wang C,Zhang C,Li W,Zhou H,Chen H,Ye Jdoi
10.1007/s12011-017-1184-ysubject
Has Abstractpub_date
2018-07-01 00:00:00pages
60-74issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-017-1184-yjournal_volume
184pub_type
杂志文章abstract::A rapid cyclic instrumental neutron activation analysis (CINAA) method has been used to determine the selenium content of 27 duplicate diet samples from each of the 27 districts surrounding Pinhel, Portugal. The accuracy and precision of the CINAA method have been evaluated by analyzing certified reference materials a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992719
更新日期:1990-07-01 00:00:00
abstract::Fruit juices are widely consumed in tropical countries as part of habitual diet. The concentrations of several minerals in these beverages were evaluated. Four commercially available brands of juices were analyzed for cadmium, lead, copper, zinc, aluminum, iron, chromium, manganese, and molybdenum. The levels ranged f...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9247-y
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abstract::Exposure of cells to ionizing radiation leads to the formation of reactive oxygen species (ROS) that are associated with radiation-induced cytotoxicity. Because of the serious damaging potential of ROS, cells depend on the elaboration of the antioxidant defense system (AODS), both enzymatic and nonenzymatic oxidant de...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:86:1:55
更新日期:2002-04-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9663-2
更新日期:2013-06-01 00:00:00
abstract::Bioenvironmental trace elements play a vital role in plant, animal, and man metabolism. This study aims to determine trace element concentration in different parts (pods, pericarp, seeds, cotyledon, and taste) of the warm climate plant pigeon pea (Cajanus cajan L. Millsp.). The pigeon pea pods were collected from the ...
journal_title:Biological trace element research
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doi:10.1007/s12011-020-02256-y
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abstract::In this study, lead acetate solution and porcine cerebral hydrolysate peptides (PCHPs) were administered to developing mice. Porcine cerebral protein pretreated by ultrasound was hydrolyzed with alcalase, and 11 peptide fragments were obtained by Matrix-assisted laser desorption ionization-time of flight mass spectrom...
journal_title:Biological trace element research
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doi:10.1007/s12011-015-0329-0
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journal_title:Biological trace element research
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doi:10.1007/s12011-020-02422-2
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:74:1:55
更新日期:2000-04-01 00:00:00
abstract::Assessment of trace element levels in general population from the specific area is of importance for nutritional and occupational monitoring. In the current study, baseline blood levels of 12 toxic and/or essential metals and metalloids, including arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), chromium (Cr), tha...
journal_title:Biological trace element research
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journal_title:Biological trace element research
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更新日期:2020-06-16 00:00:00
abstract::Concentration of heavy metals (lead (Pb), cadmium (Cd), chromium (Cr), and copper (Cu)) was determined in the liver, gills, kidneys, and muscles of eight edible fish species (Channa punctata, Cirrhinus reba, Labeo rohita, Heteropneustes fossilis, Mystus cavasius, Oreochromis niloticus, Puntius sophore, and Wallago att...
journal_title:Biological trace element research
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doi:10.1007/s12011-011-9011-3
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abstract::We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 m...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02789076
更新日期:1995-04-01 00:00:00
abstract::In vivo X-ray fluorescence (XRF) techniques were used for biological monitoring of lead, cadmium, and mercury. Lead accumulates in bone, the level of which may thus be used for monitoring of exposure. However, there was no close association between lead levels in bone and exposure time, partly because of differences i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796636
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abstract::Selenium (Se) mainly performs its function through Se-containing proteins. Selenoprotein W (SelW), one member of the selenoprotein family, plays important roles in the normal function of the heart. To investigate the possible relationship between Se and SelW for the regulation of oxidative damage in chicken embryo myo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0529-7
更新日期:2016-06-01 00:00:00
abstract::Manganese (Mn) is an essential element for normal development and bodily functions in humans. In the present study, we examined whether Mn supplementation can alter the serum lipid parameters and liver function in Ca-deficient ovariectomized (OVX) rats. Sixty female Sprague-Dawley rats (6 weeks) were divided into five...
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更新日期:2011-06-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8024-4
更新日期:2007-01-01 00:00:00
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journal_title:Biological trace element research
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doi:10.1007/s12011-013-9600-4
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abstract::Obesity, a chronic inflammatory state, is associated with altered zinc metabolism. ZnT and Zip transporters are involved in the regulation of zinc metabolism. This study examined the relationships among obesity, zinc transporter gene expression, and inflammatory markers in young Korean women. The messenger RNA (mRNA) ...
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journal_title:Biological trace element research
pub_type: 杂志文章
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journal_title:Biological trace element research
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doi:10.1007/s12011-015-0511-4
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journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-011-9144-4
更新日期:2011-12-01 00:00:00
abstract::The objective of this study was to determine whether different dietary vitamin E (VE) and selenium (Se) levels affect the nutrient digestibility, production performance, and antioxidant abilities of growing furring blue foxes. A 4 × 2 factorial arrangement that included 4 levels of VE (0, 100, 200, or 400 mg/kg diet f...
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abstract::The effects of zinc on growing rats were characterized using the dietary zinc-deficient (ZD) and Zinc-overdose (ZO) models. Zinc deficiency had negative effects on the host final body weight and liver zinc content, whereas zinc overdose had positive effects. In order to identify the molecular changes in the liver resp...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02686028
更新日期:2007-02-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02788961
更新日期:1995-08-01 00:00:00
abstract::Characterization of coffee terroirs is important to determine authenticity and provide confidence for consumers to select the right product. In this regard, Amhara Region, which is located at the northwestern part of Ethiopia, produces various local coffee types with distinct cup qualities. The coffees are, however, n...
journal_title:Biological trace element research
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doi:10.1007/s12011-019-01866-5
更新日期:2020-06-01 00:00:00
abstract::The objective was to determine if a mammary cell line shows glucocorticoid stimulation of Zn uptake, and to determine whether polyamines mediate this stimulation. 65Zn uptake by COMMA-1D mouse mammary epithelial cells over a 24-h period increased significantly in cells administered 10(-7) or 10(-6) M hydrocortisone. I...
journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785409
更新日期:1995-12-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1077-0
更新日期:2018-03-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990427
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