Abstract:
:Deficiency of intracellular magnesium (icMg) may coexist with normal serum Mg levels. Little is known about clinical and pharmacological factors affecting icMg in normomagnesemic patients with diabetes mellitus (DM). Moreover, no information exists regarding the icMg state in diabetic patients after acute illness and before hospital discharge. We have evaluated the effect of antihyperglycemic medications and other relevant clinical variables on icMg in 119 such patients. Total icMg was measured in peripheral blood mononuclear cells. Twenty healthy volunteers served as controls. IcMg content (microg/mg cell protein) was lower in DM compared to controls (1.74 +/- 0.44 vs 2.4 +/- 0.39, p < 0.001). It was also significantly lower in patients treated with insulin (1.57 +/- 0.31 vs 1.8 +/- 0.46, p = 0.01), while metformin treatment was associated with higher icMg (1.86 +/- 0.49 vs 1.63 +/- 0.35, p = 0.003). After adjustment for age, gender, and concomitant use of other hypoglycemic drugs, only treatment with metformin was independently associated with increased icMg (p = 0.03). No statistically significant association or correlation was found between icMg content and age, causes of hospitalization, comorbid conditions, treatment with other drugs, concentrations of HbA1c, serum glucose, Mg, or creatinine. In conclusion, icMg is depleted in normomagnesemic DM patients. Insulin treatment is associated with worsening of icMg status, while metformin treatment may confer protective effect.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Gorelik O,Efrati S,Berman S,Almoznino-Sarafian D,Alon I,Shteinshnaider M,Cohen Ndoi
10.1007/s12011-007-8024-4subject
Has Abstractpub_date
2007-01-01 00:00:00pages
102-9issue
1-3eissn
0163-4984issn
1559-0720pii
BTER:120:1-3:102journal_volume
120pub_type
杂志文章abstract::The selenium levels and the glutathione peroxidase activity GSH-PX of whole blood and of erythrocytes, respectively, were determined in 139 normal Danes and related to sex and smoking habits. No differences were found in relation to sex apart from a higher GSH-PX activity of females when assayed with tertiary butyl hy...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02990131
更新日期:1988-01-01 00:00:00
abstract::The forms of Se in the Se-dependent enzyme formate dehydrogenase is known to be selenocysteine, but the way this amino acid enters the polypeptide chain has not been established. Through the use of a cysteine-requiring mutant ofEscherichia coli K-12 that could also grow in the presence of glutathione, we were able to ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795520
更新日期:1986-12-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789188
更新日期:1995-05-01 00:00:00
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journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-014-9943-5
更新日期:2014-06-01 00:00:00
abstract::Selenium deficiency is known to cause cardiovascular diseases. However, the role of Se deficiency in causing oxidative damage and inflammation injury to the aorta vessels of chickens is not well known. In the present study, 180 1-day-old chickens were randomly divided into two groups, a low-Se group (L group) and a co...
journal_title:Biological trace element research
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abstract::Kashin-Beck disease (KBD) is an endemic, degenerative osteoarthropathy, and particularly seen in China. A deficiency of selenium and iodine is implicated as the main etiological factor for KBD. This meta-analysis aimed to evaluate the differences in the selenium and iodine levels between patients with KBD and healthy ...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析
doi:10.1007/s12011-015-0463-8
更新日期:2016-03-01 00:00:00
abstract::Cadmium (Cd) is a highly toxic heavy metal that can affect human and animal health. Selenium (Se) is an essential microelement that can protect various organs against toxic heavy metals. Although many studies have investigated the adverse effect of Cd in rats and several other animals, little is known regarding the me...
journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
abstract::In this study, hair levels of Cu and Zn were determined in healthy male and female individuals (n = 192) ages 3.6-14.5 yr and the correlations with Cu and Zn daily intakes were examined. Determinations of Cu and Zn concentrations were performed by way of atomic absorption spectrometry and X-ray fluorescence. Nutrition...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02950788
更新日期:1994-02-01 00:00:00
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abstract::Copper (Cu) and zinc (Zn) are involved in inflammatory process. This study was to investigate the clinical significance of Cu and Zn homeostasis alterations in acute appendicitis (AA). One hundred twenty-two AA patients and 102 healthy controls were enrolled in this study. Of which, 85 patients' appendixes were collec...
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02788959
更新日期:1995-08-01 00:00:00
abstract::The small intestine is one of the target organs of dietary selenium (Se) deficiency. Our objective was to investigate the effects of Se deficiency on small intestinal mucosa morphology and function in chickens. In the present study, 1-day (d)-old chickens were fed either a commercial diet with 0.15 mg/kg Se (control g...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-02017-6
更新日期:2020-10-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917265
更新日期:1989-07-01 00:00:00
abstract::Conflicting results exist between selenium concentration and preeclampsia. The role of selenium in the development of preeclampsia is unclear. We conducted a meta-analysis to compare the blood selenium level in patients with preeclampsia and healthy pregnant women, and to determine the effectiveness of selenium supple...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12011-015-0545-7
更新日期:2016-06-01 00:00:00
abstract::Selenium is known to be a neuroprotective agent in respect to a number of neuronal diseases and pain. The aim of this study was to evaluate the neuroprotective effect of the oral administration of selenium nanoparticles in rats with spinal cord injury (SCI). Forty adult female rats were randomly assigned to two equal ...
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9640-9
更新日期:2013-06-01 00:00:00
abstract::Pituitary dwarfism (hGHD) is known to be associated with trace element deficiency, which causes improper functioning of the involved endocrine system. Previously, we reported on the head hair concentrations of zinc, copper, manganese, and iron from a total of 418 normal subjects (154 male and 264 female). In this repo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:85:2:127
更新日期:2002-02-01 00:00:00
abstract::Arsenic (As), antimony (Sb), and bismuth (Bi) are metalloids that share similar chemical properties, the objective of this study was to characterize the uptake and accumulation of these metalloids by plants colonized on heavy contaminated sites in an old Sb mine. Sixty-five plant samples from seven species as well as ...
journal_title:Biological trace element research
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更新日期:2011-12-01 00:00:00
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789301
更新日期:1994-12-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:1990-05-01 00:00:00
abstract::Placental type 3 iodothyronine deiodinase (D3) potentially protects the fetus from the elevated maternal thyroid hormones. Na(+)/I(-) symporter (NIS) is a plasma membrane glycoprotein, which mediates active iodide uptake. Our objectives were to establish the distribution of NIS and D3 gene expressions in the placenta ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9748-y
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
abstract::Zinc (Zn) is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study was performed to investigate the effects of three Zn levels, including Zn adequate (35.94 mg/kg, as a control), Zn deficienc...
journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02276-8
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