Abstract:
:Sea cucumbers are a potential source of natural organic vanadium that may improve insulin resistance. In this work, vanadium was accumulated rapidly in blood, body wall, and intestine by sea cucumber Apostichopus japonicus. Furthermore, water-soluble vanadium-containing proteins, the main form of the organic vanadium, were tentatively accumulated and isolated by a bioaccumulation experiment. It was also designed to evaluate the beneficial effect of vanadium-containing proteins (VCPs) from sea cucumber rich in vanadium on the development of hyperglycemia and insulin resistance in C57BL/6J mice fed with a high-fat high-sucrose diet (HFSD). HFSD mice treated with VCPs significantly decreased fasting blood glucose, serum insulin, and HOMA-IR values as compared to HFSD mice, respectively. Serum adiponectin, resistin, TNF-α, and leptin levels in insulin-resistant mice were dramatically reduced by a VCP supplement. These results show an ameliorative effect on insulin resistance by treatment with VCPs. Such compound seems to be a valuable therapy to achieve and/or maintain glycemic control and therapeutic agents in the treatment arsenal for insulin resistance and type 2 diabetes.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Liu Y,Zhou Q,Zhao Y,Wang Y,Wang Y,Wang J,Xu J,Xue Cdoi
10.1007/s12011-015-0517-ysubject
Has Abstractpub_date
2016-05-01 00:00:00pages
167-75issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-015-0517-yjournal_volume
171pub_type
杂志文章abstract::Microcalorimetry was employed to investigate the action of Li(I) to aquatic ecosystem from the point view of bioenergetics. Tetrahymena thermophila BF5 was chosen as the model organism. The power-time curves of T. thermophila BF5 growth metabolism in the absence and presence of Li(I) were obtained. The corresponding t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-0040-x
更新日期:2007-10-01 00:00:00
abstract::We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 m...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02789076
更新日期:1995-04-01 00:00:00
abstract::Little is known about the influence of subchronic cadmium exposure on apoptosis in the immune organs of birds and the protective effects on apoptosis by selenium against cadmium. The aim of this study was to investigate the effect of subchronic cadmium exposure on nitric oxide and apoptosis in the immune organs of chi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0007-7
更新日期:2014-06-01 00:00:00
abstract::The k0 standardization method was adapted for NAA with stable low-flux reactors where flux monitors are not needed. The modified k0 method offers the convenience of the use of libraries of sensitivity constants. It was compared to the relative method for 52 elements using a SLOWPOKE reactor and 6 counting geometries. ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784232
更新日期:1999-01-01 00:00:00
abstract::Gender differences are related to the manner in which the heart responds to chronic and acute stress conditions of physiological and pathological nature. Depending on dose, sodium selenite acts as an antioxidant proven to have beneficial effects in several pathological conditions G. Drasch, J. Schopfer, and G. N. Schr...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02698014
更新日期:2007-06-01 00:00:00
abstract::The forms of Se in the Se-dependent enzyme formate dehydrogenase is known to be selenocysteine, but the way this amino acid enters the polypeptide chain has not been established. Through the use of a cysteine-requiring mutant ofEscherichia coli K-12 that could also grow in the presence of glutathione, we were able to ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795520
更新日期:1986-12-01 00:00:00
abstract::In vivo X-ray fluorescence (XRF) techniques were used for biological monitoring of lead, cadmium, and mercury. Lead accumulates in bone, the level of which may thus be used for monitoring of exposure. However, there was no close association between lead levels in bone and exposure time, partly because of differences i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796636
更新日期:1987-08-01 00:00:00
abstract::Elemental concentrations in head hair and blood (whole-blood, erythrocytes and plasma) of 28 Nigerian subjects were determined using instrumental neutron activation analysis (INAA) and proton-induced X-ray emission (PIXE) techniques. Correlations found between different elements in hair and blood are reported. Hair le...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02917347
更新日期:1994-10-01 00:00:00
abstract::To examine whether there were differences between races in regard to age-related changes of elements and the relationships among elements in the arteries, the authors investigated both the renal arteries of Thai and Japanese. The Thai subjects consisted of 27 men and 11 women, ranging in age from 27 to 88 yr, whereas ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:106:3:219
更新日期:2005-09-01 00:00:00
abstract::Serum iron levels have been shown to decline both with fever and with strenuous exercise, leading to the supposition that the decrease might be the result of a rise in core body temperature. To evaluate this hypothesis, the serum iron response to an exercise-induced 1.5 degrees C rise in core body temperature was meas...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:108:1-3:061
更新日期:2005-01-01 00:00:00
abstract::The influence of several commercial albumin preparations on the ferroxidase activity of ceruloplasmin (ferroxidase I, ferrous: O2 oxidoreductase EC 1.16.3.1) at pH 6.0 was determined using ferric-transferrin formation. The ability of several albumin preparations to inhibit the ferroxidase activity of ceruloplasmin dif...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916628
更新日期:1983-04-01 00:00:00
abstract::Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) bas...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9325-9
更新日期:2012-06-01 00:00:00
abstract::This study aimed to investigate the effects of vitamin D and magnesium co-supplementation on muscle strength and function, body composition, and inflammation in vitamin D-deficient middle-aged women. In this study, 83 healthy middle-aged women (40-55 years) with vitamin D deficiency were randomly assigned into two gro...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02387-2
更新日期:2020-09-21 00:00:00
abstract::The aim of the current study was to assess relationships between multiple metals burden in human seminal plasma and semen quality parameters. Levels of five metals (lead, manganese, copper, arsenic, and selenium) in human seminal plasma were determined by inductively coupled plasma mass spectrometry (ICP-MS), and the ...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-012-9335-7
更新日期:2012-07-01 00:00:00
abstract::Smoking is one of the major causes of mortality and numerous diseases, both directly and indirectly. The role of smoking as a significant risk factor is already known in several human diseases such as cardiovascular diseases, lung cancer, and chronic obstructive pulmonary disease. We aimed to compare the toxicity of h...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02537-6
更新日期:2021-01-20 00:00:00
abstract::Cadmium (Cd) is an environmental toxicant and an inflammation-related xenobiotic. Selenium (Se) is a well-known nutritional trace element and a potent chemopreventive agent. The present study aimed to investigate the effect of Se on the cytotoxicity of Cd in bird immunocytes in vitro. Chicken splenic lymphocytes expos...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0354-z
更新日期:2015-11-01 00:00:00
abstract::Neonatal uptake of mercury (Hg) from milk was examined in a pregnant sheep model, where radioactive mercury (Hg203)/silver tooth fillings (amalgam) were newly placed. A crossover experimental design was used in which lactating ewes nursed foster lambs. In a parallel study, the relationship between dental history and b...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785388
更新日期:1997-02-01 00:00:00
abstract::In the present world, X-rays have been regarded as one of the most efficient tools in medicine, industry and research. On the contrary, extensive human exposure to these rays is responsible for causing detrimental effects on physiological system. The aim of the present study was to investigate the role of zinc (Zn), i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-0976-4
更新日期:2017-10-01 00:00:00
abstract::Contents of Cu and Zn of into-pulmonary blood (IPB), out-pulmonary blood (OPB), Lung tissue, and supernatant and macrophages of Lung Lavage were determined in superior mesenteric artery occlusion (SMAO) shock of rabbits. Zn of pulmonary tissue was 11.42 +/- 0.60 and 14.52 +/- 1.78 (micrograms/g wet wt) in SMAO shock a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF03032684
更新日期:1991-06-01 00:00:00
abstract::Modifications in the enzyme activity of lysozyme, a protein implied in the defence barrier of the organism, can be a good biomarker of alterations in the immune system as a result of exposure to toxic metal, such as lead. The aim of this work was to evaluate the effect of a 200 ppm dose of lead on lysozyme activity in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9446-1
更新日期:2012-12-01 00:00:00
abstract::Some studies have found that nano-sized titanium dioxide (nano-TiO2) has adverse effects on the male reproductive system. Blood-testis barrier (BTB), as one of the tightest blood-tissue restriction, is crucial to the male reproductive system. However, the potential effects on BTB and signaling pathway changes in testi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02404-4
更新日期:2020-09-29 00:00:00
abstract::In this study, hair levels of Cu and Zn were determined in healthy male and female individuals (n = 192) ages 3.6-14.5 yr and the correlations with Cu and Zn daily intakes were examined. Determinations of Cu and Zn concentrations were performed by way of atomic absorption spectrometry and X-ray fluorescence. Nutrition...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02950788
更新日期:1994-02-01 00:00:00
abstract::Indigenous preparations (IPs) have evoked a considerable interest in alleviating infections and chronic diseases and improving wellbeing. While such formulations have been a part of traditional practice in several countries and many have been reviewed scientifically for their claims, several of them until date remain ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1411-1
更新日期:2019-04-01 00:00:00
abstract::This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO4) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO4 strongly inhibited the replic...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01728-0
更新日期:2020-02-01 00:00:00
abstract::In a controlled animal experiment the effects of dietary subacute Zn deficiency on growth, Zn concentration, and tissue 42-K distribution were studied. Growth retardation caused lower body weight because both skeletal and heart muscle showed a reduction in cell mass. Zn concentrations were reduced in most tissues, how...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789301
更新日期:1994-12-01 00:00:00
abstract::Our previous studies showed that serum calcium level may have influence in the blood pressure to older male subjects, but the relationship between serum calcium level and blood lipids is unclear. The aim of this study was to evaluate the relationship between total serum calcium level and blood lipids. In our study, to...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9895-9
更新日期:2014-03-01 00:00:00
abstract::To elucidate the element content of newborn blood vessels, umbilical arteries and veins in human umbilical cords, which had the advantage of easy sampling, were examined by ICP-AES. Umbilical cords were removed after birth. Mothers' ages ranged from 26 to 35 yr. It was found that the content of sulfur was the highest ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783875
更新日期:1999-09-01 00:00:00
abstract::In this study, a new method was developed for the pre-concentration of trace mercury from seafood samples prior to analysis by spectrophotometry. The method is based on the complexation between 2-hydrazinobenzothiazole (2-HBT)-modified copolymer(s) and Hg(II) in the presence of an ionic surfactant, cetyltrimethylammon...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1614-5
更新日期:2019-09-01 00:00:00
abstract::An "anti-oxidant cocktail" consisting of betacarotene, vitamins B6, C, E, zinc, and selenium or corresponding placebos were given for one y as daily dietary supplements to 45 elderly residents of a nursing home. Initially, the serum TBA reactant levels were higher (2.7 +/- 0.7 mumol/L) than those of an ad hoc control ...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02795458
更新日期:1988-09-01 00:00:00
abstract::Age-related changes in the concentrations of constituent elements in the brains of rats and mice 1 wk to 24 mo old were determined with inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES). Seventeen elements could be determined with reasonable acc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:80:2:145
更新日期:2001-05-01 00:00:00