Identification of citrate as the albumin-bound inhibitor of the ferroxidase activity of ceruloplasmin.

Abstract:

:The influence of several commercial albumin preparations on the ferroxidase activity of ceruloplasmin (ferroxidase I, ferrous: O2 oxidoreductase EC 1.16.3.1) at pH 6.0 was determined using ferric-transferrin formation. The ability of several albumin preparations to inhibit the ferroxidase activity of ceruloplasmin differs more than three hundredfold. It appears to depend on the method of isolation of albumin rather than the source of albumin, suggesting the existence of an inhibitor bound to albumin. The inhibitor was isolated after chromatography of an albumin preparation on Sephadex G-200. It was identified as citrate by thin layer chromatography and by comparison of the spectrum of the sulfide-pentabromoacetone derivative. Albumin preparations, even with bound citrate, do not exert a significant inhibitory effect at pH 7.4.

journal_name

Biol Trace Elem Res

authors

Witwicki J,Chidambaram MV,Frieden E

doi

10.1007/BF02916628

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

81-90

issue

2

eissn

0163-4984

issn

1559-0720

journal_volume

5

pub_type

杂志文章
  • Application of nuclear analytical techniques using long-life sealed-tube neutron generators.

    abstract::The new range of sealed-tube neutron generators developed by SODERN appears to be appropriate for the industrial environment. The main characteristics are the high emission stability during the very long lifetime of the tube, flexible pulsed mode capability, safety in operation with no radiation in "off" state, and th...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02917309

    authors: Bach P,Cluzeau S,Lambermont C

    更新日期:1994-10-01 00:00:00

  • Impaired iron status in rats as induced by copper deficiency.

    abstract::The hypothesis was tested that marginal copper deficiency affects iron status. Copper restriction (1 vs 5 mg Cu/kg diet) significantly lowered iron concentrations and transferrin saturation in plasma and reduced blood hemoglobin, hematocrit, and iron concentrations in tibia and femur, but raised iron concentrations in...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02786240

    authors: Van Den Berg GJ,Van Houwelingen F,Lemmens AG,Beynen AC

    更新日期:1992-10-01 00:00:00

  • Selenoprotein W was Correlated with the Protective Effect of Selenium on Chicken Myocardial Cells from Oxidative Damage.

    abstract::Selenium (Se) mainly performs its function through Se-containing proteins. Selenoprotein W (SelW), one member of the selenoprotein family, plays important roles in the normal function of the heart. To investigate the possible relationship between Se and SelW for the regulation of oxidative damage in chicken embryo myo...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0529-7

    authors: Liu W,Yao H,Zhao W,Shi Y,Zhang Z,Xu S

    更新日期:2016-06-01 00:00:00

  • Effect of Dietary Selenium Deficiency on the Cell Apoptosis and the Level of Thyroid Hormones in Chicken.

    abstract::This study assessed the effect of dietary selenium (Se) deficiency on male reproductive function in chicken. A total of 180 Hy-line laying cocks (1 day old; Weiwei) were randomly divided into 2 groups (n = 90) of Se-deficient chickens and control chickens. The control group was fed a basic diet (containing 0.15 mg of ...

    journal_title:Biological trace element research

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12011-015-0534-x

    authors: Huang Y,Li W,Xu D,Li B,Tian Y,Zan L

    更新日期:2016-06-01 00:00:00

  • Decrease of CD4+ T-lymphocytes in children exposed to environmental lead.

    abstract::The effects of environmental lead on the immune system of young children were assessed by determining the peripheral blood lymphocytes CD3+, CD4+, CD8+, B(CD19+) counts, and natural killer (CD16+CD56+) cells in 35 preschool children whose mean blood lead level was 140.6 microg/L. The results were compared to an age- a...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:105:1-3:019

    authors: Li S,Zhengyan Z,Rong L,Hanyun C

    更新日期:2005-07-01 00:00:00

  • The alteration of miR-222 and its target genes in nickel-induced tumor.

    abstract::Nickel is an important kind of metal and a necessary trace element in people's production and livelihood; it is also a well-confirmed human carcinogen. In the past few years, researchers did a large number of studies about the molecular mechanisms of nickel carcinogenesis, and they focused on activation of proto-oncog...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-013-9619-6

    authors: Zhang J,Zhou Y,Ma L,Huang S,Wang R,Gao R,Wu Y,Shi H,Zhang J

    更新日期:2013-05-01 00:00:00

  • Bioaccumulation of trace elements in trophic levels of wetland plants and waterfowl birds.

    abstract::Present study investigates relationships between total and bioaccessibility of trace elements (Cd, Co, Cr, Cu, Mn, NI, Pb, V, and Zn) concentrations in sediment and their bioaccumulation in species in Shadegan wetland in southwest of Iran. Bioavailability factor (BAF) and translocation factor (TF) were calculated in p...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8795-x

    authors: Alhashemi AS,Karbassi AR,Kiabi BH,Monavari SM,Nabavi SM,Sekhavatjou MS

    更新日期:2011-09-01 00:00:00

  • Selenium and mercury in native and introduced fish species of patagonian lakes, Argentina.

    abstract::A survey of mercury (Hg) and selenium (Se) contents was performed in fish collected from lakes located in two National Parks of the northern patagonian Andean range. Two native species, catfish (Diplomystes viedmensis) and creole perch (Percichthys trucha), and three introduced species, brown trout (Salmo trutta), rai...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-007-8059-6

    authors: Arribére MA,Ribeiro Guevara S,Bubach DF,Arcagni M,Vigliano PH

    更新日期:2008-04-01 00:00:00

  • Biological monitoring, by in vivo XRF measurements, of occupational exposure to lead, cadmium, and mercury.

    abstract::In vivo X-ray fluorescence (XRF) techniques were used for biological monitoring of lead, cadmium, and mercury. Lead accumulates in bone, the level of which may thus be used for monitoring of exposure. However, there was no close association between lead levels in bone and exposure time, partly because of differences i...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02796636

    authors: Skerfving S,Christoffersson JO,Schütz A,Welinder H,Spång G,Ahlgren L,Mattsson S

    更新日期:1987-08-01 00:00:00

  • Selenium and L-carnitine reduce oxidative stress in the heart of rat induced by 2.45-GHz radiation from wireless devices.

    abstract::The aim of this study was to investigate the possible protective role of selenium and L-carnitine on oxidative stress induced by 2.45-GHz radiation in heart of rat. For this purpose, 30 male Wistar Albino rats were equally divided into five groups namely controls, sham controls, radiation-exposed rats, radiation-expos...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-011-8994-0

    authors: Türker Y,Nazıroğlu M,Gümral N,Celik O,Saygın M,Cömlekçi S,Flores-Arce M

    更新日期:2011-12-01 00:00:00

  • Effects of stimulation of copper bioleaching on microbial community in vineyard soil and copper mining waste.

    abstract::Long-term copper application in vineyards and copper mining activities cause heavy metal pollution sites. Such sites need remediation to protect soil and water quality. Bioremediation of contaminated areas through bioleaching can help to remove copper ions from the contaminated soils. Thus, the aim of this work was to...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-011-9213-8

    authors: Andreazza R,Okeke BC,Pieniz S,Bortolon L,Lambais MR,Camargo FA

    更新日期:2012-04-01 00:00:00

  • Determination of arsenic in scalp hair of children and its correlation with drinking water in exposed areas of Sindh Pakistan.

    abstract::This study was focused on the analysis of arsenic (As) levels in scalp hair of children (age, <10 years) collected from two towns of Khairpur, Pakistan, to evaluate the effects of As-contaminated groundwater. For comparative purposes, scalp hair samples of children were also collected from that area having low levels ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8866-z

    authors: Kazi TG,Baig JA,Shah AQ,Arain MB,Jamali MK,Kandhro GA,Afridi HI,Kolachi NF,Khan S,Wadhwa SK,Shah F

    更新日期:2011-10-01 00:00:00

  • Blood levels of copper, iron, zinc, and lead in adults in India and Pakistan and the effect of oral zinc supplementation for six weeks.

    abstract::Deficiency in the intake of trace elements, such as copper (Cu), iron (Fe), selenium (Se), and zinc (Zn), is very common in the general population of most developing countries. A preliminary study in India and Pakistan showing the plasma levels of Zn and Fe indicates that approx 50% of the subjects who participated ha...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02789092

    authors: Abdulla M,Suck C

    更新日期:1998-03-01 00:00:00

  • Mercury, Lead, Cadmium, and Barium Levels in Human Breast Milk and Factors Affecting Their Concentrations in Hamadan, Iran.

    abstract::Breast milk is considered the best source of nutrition for all infants. However, exposure of newborns to toxic metals is of special interest due to their potential harmful effects. Thus, the primary aims of this study were to determine the concentration of toxic heavy metals including lead, mercury, cadmium, and bariu...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-018-1355-5

    authors: Vahidinia A,Samiee F,Faradmal J,Rahmani A,Taravati Javad M,Leili M

    更新日期:2019-01-01 00:00:00

  • Comparative in situ study of the intestinal absorption of aluminum, manganese, nickel, and lead in rats.

    abstract::This comparative study of the intestinal absorption of four toxic metals (aluminum, manganese, nickel, and lead) carried out in rats using the in situ intestinal perfusion technique was able to measure the partition of each metal between the intestine (intestinal retention), the blood circulation, and target tissues a...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:99:1-3:157

    authors: Arnich N,Cunat L,Lanhers MC,Burnel D

    更新日期:2004-07-01 00:00:00

  • Selenium Deficiency Downregulates Selenoproteins and Suppresses Immune Function in Chicken Thymus.

    abstract::Selenoproteins and selenium (Se) play important roles in the immune system. Selenoprotein expression in the immune system of mammals is sensitive to dietary Se levels; however, little is known about the expression of selenoproteins and their immune functions in the chicken thymus. We assessed selenoprotein gene expres...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0282-y

    authors: Khoso PA,Yang Z,Liu C,Li S

    更新日期:2015-09-01 00:00:00

  • Effect of some nickel compounds on red blood cell characteristics.

    abstract::The effect of certain inorganic and coordinated nickel compounds on the resistance to different destructive substances, rheological properties, and functional activity of healthy human red blood cells (RBC), was investigated. It is shown that nickel compounds affect the erythrocyte membrane lipid bilayer, as well as m...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02917273

    authors: Tkeshelashvili LK,Tsakadze KJ,Khulusauri OV

    更新日期:1989-07-01 00:00:00

  • Zinc Metabolism and Metallothioneins.

    abstract::Among the trace elements, zinc is one of the most used elements in biological systems. Zinc is found in the structure of more than 2700 enzymes, including hydrolases, transferases, oxyreductases, ligases, isomerases, and lyases. Not surprisingly, it is present in almost all body cells. Preserving the stability and int...

    journal_title:Biological trace element research

    pub_type: 杂志文章,评审

    doi:10.1007/s12011-017-1119-7

    authors: Baltaci AK,Yuce K,Mogulkoc R

    更新日期:2018-05-01 00:00:00

  • Body fat percentage and hemoglobin levels are related to blood lead, cadmium, and mercury concentrations in a Korean Adult Population (KNHANES 2008-2010).

    abstract::Body stores of lead, cadmium, and mercury are determined by the levels in the circulation, and their levels in blood may be related to hemoglobin levels and their absorption by soft tissue and bone. We investigated the association of body fat percentage, hemoglobin levels, and nutrient intakes with the blood concentra...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-012-9566-7

    authors: Park S,Lee BK

    更新日期:2013-03-01 00:00:00

  • Effects of selenium supplementation on virus-induced inflammatory heart disease.

    abstract::The effects of 10 wk of selenium (Se) supplementation (5 ppm) in drinking water on immune responses and resistance to a myocarditic Coxsackie virus B3 (CB3) infection were studied in female Balb/c mice. Se supplementation reduced CB3-induced mortality: at day 14 postinoculation, survival was 58% in the Se-treated grou...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02785277

    authors: Ilbäck NG,Fohlman J,Friman G

    更新日期:1998-07-01 00:00:00

  • The effect of copper on glutathione metabolism in human leukocytes.

    abstract::Leukocytes incubated with Cu(II) showed a decrease in both glutathione reductase activity and reduced glutathione content. The glucose 6-phosphate dehydrogenase activity under the same conditions was not affected. Serum albumin added to mixtures prevented the loss of enzyme activity, whileD-penicillamine andL-histidin...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783258

    authors: Rafter GW

    更新日期:1982-06-01 00:00:00

  • Enhanced sensitivity for the determination of selenium by INAA.

    abstract::A working analytical procedure for selenium determinations by INAA, using gamma spectrometry with a germanium well-type detector, is presented. The spectral line at 400.7 keV is employed, enhanced with the effect of energy summing in true coincidence of cascade photons. The main advantage of the method is high efficie...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02917304

    authors: Makarewicz M,Zeisler R

    更新日期:1994-10-01 00:00:00

  • Chromium in Postmortem Material.

    abstract::Recently, considerable attention has been paid to the negative effects caused by the presence and constant increase in concentration of heavy metals in the environment, as well as to the determination of their content in human biological samples. In this paper, the concentration of chromium in samples of blood and int...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-018-1328-8

    authors: Dudek-Adamska D,Lech T,Konopka T,Kościelniak P

    更新日期:2018-12-01 00:00:00

  • Gamma-Glutamyl Cysteine Attenuates Tissue Damage and Enhances Tissue Regeneration in a rat Model of Lead-Induced Nephrotoxicity.

    abstract::Lead is a biohazardous metal that is commonly involved in human illness including renal injury. Although it is a non-redox reactive metal, lead-induced renal injury is largely based on oxidative stress. The current work aimed at exploring the possible protective effect of γ-glutamyl cysteine (γGC) against lead-induced...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-016-0624-4

    authors: Salama SA,Arab HH,Maghrabi IA,Hassan MH,AlSaeed MS

    更新日期:2016-09-01 00:00:00

  • Biological Evaluation of Hot-Melt Extruded Nano-selenium and the Role of Selenium on the Expression Profiles of Selenium-Dependent Antioxidant Enzymes in Chickens.

    abstract::A study was conducted to determine the effect of dietary selenium (Se) concentration and source for broiler chickens on performance, nutrient digestibility, plasma Se, glutathione peroxidase (GPx) activity, and thiobarbituric acid reactive substances (TBARS). A total of 700 1-day-old broiler chicks were assigned to 7 ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01801-8

    authors: Lee J,Hosseindoust A,Kim M,Kim K,Choi Y,Lee S,Lee S,Cho H,Kang WS,Chae B

    更新日期:2020-04-01 00:00:00

  • Interactions of mercury in rat brain.

    abstract::In order to study the metabolism of mercury (Hg), its affinity to metallothionein (MT), and its influence on levels of the essential metals copper and zinc in the brain tissue of rats exposed to elemental mercury (HgO) vapor was investigated. The major findings were: 1. After long-term exposure, about 40% of mercury w...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02789402

    authors: Falnoga I,Kregar I,Skreblin M,Tusek-Znidaric M,Stegnar P

    更新日期:1993-04-01 00:00:00

  • Do zinc and selenium prevent the antioxidant, hepatic and renal system impairment caused by aspirin in rats?

    abstract::Aspirin is widely used as an antiinflammatory drug especially in children with rheumatic fever arthritis. The diminishing effects of aspirin on antioxidant enzymes and hepato-renal systems at high doses are well-known. It is now evident that the damage at antioxidant system worsens the clinical picture of the disease ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-008-8115-x

    authors: Kesik V,Lenk MK,Kurekci AE,Acikel CH,Akgul EO,Aydin A,Erdem O,Gamsizkan M

    更新日期:2008-07-01 00:00:00

  • Gene expression profiles analysis of the growing rat liver in response to different zinc status by cDNA microarray analysis.

    abstract::The effects of zinc on growing rats were characterized using the dietary zinc-deficient (ZD) and Zinc-overdose (ZO) models. Zinc deficiency had negative effects on the host final body weight and liver zinc content, whereas zinc overdose had positive effects. In order to identify the molecular changes in the liver resp...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02686028

    authors: Sun JY,Wang JF,Zi NT,Jing MY,Weng XY

    更新日期:2007-02-01 00:00:00

  • Effect of dietary vanadium on the ileac T cells and contents of cytokines in broilers.

    abstract::The purpose of this 42-day study was to examine the effect of dietary vanadium on the ileac T cells and contents of cytokines including interleukin-2 (IL-2), interleukin-6 (IL-6), and interferon-gamma (IFN-γ) in broilers by flow cytometry and enzyme-linked immunosorbent assay. A total of 420 one-day-old avian broilers...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-011-9274-8

    authors: Wang K,Cui H,Deng Y,Peng X,Fang J,Zuo Z,Cui W

    更新日期:2012-06-01 00:00:00

  • Concentration levels of major and trace elements in rice from Sri Lanka as determined by the k0 standardization method.

    abstract::Instrumental neutron activation (INAA) with k0 standardization has been used to determine the concentration levels of a variety of major and trace elements (Al, As, Br, Cd, Cl, Co, Cr, Cs, Cu, Fe, Hg, K, La, Mg, Mn, Mo, Na, Rb, Sc, Se, and Zn) in rice grains (raw and parboiled) and in rice flour collected from local m...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:103:1:083

    authors: Jayasekera R,Freitas MC

    更新日期:2005-01-01 00:00:00