Decrease of CD4+ T-lymphocytes in children exposed to environmental lead.

Abstract:

:The effects of environmental lead on the immune system of young children were assessed by determining the peripheral blood lymphocytes CD3+, CD4+, CD8+, B(CD19+) counts, and natural killer (CD16+CD56+) cells in 35 preschool children whose mean blood lead level was 140.6 microg/L. The results were compared to an age- and sex-matched control group with a mean blood lead level of 64.3 microg/L. Compared to the controls, a significant reduction in the percentage of CD4+ cells and a significant increase of CD8+ cells were seen in the high-lead group. The negative correlation between the percentage of CD4+ cells and blood lead levels was found to be significant (p<0.01). These results suggest that exposure to environmental lead might result in alterations in the immune function of young children.

journal_name

Biol Trace Elem Res

authors

Li S,Zhengyan Z,Rong L,Hanyun C

doi

10.1385/BTER:105:1-3:019

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

19-25

issue

1-3

eissn

0163-4984

issn

1559-0720

pii

BTER:105:1-3:019

journal_volume

105

pub_type

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