Abstract：
:Lead is a biohazardous metal that is commonly involved in human illness including renal injury. Although it is a non-redox reactive metal, lead-induced renal injury is largely based on oxidative stress. The current work aimed at exploring the possible protective effect of γ-glutamyl cysteine (γGC) against lead-induced renal injury. Rats were allocated to normal and γGC control groups, lead-treated group, and lead and γGC-treated group. γGC alleviated lead-induced renal injury as evidenced by attenuation of histopathological aberration, amelioration of oxidative injury as demonstrated by significant reduction in lipid and protein oxidation, elevation of total antioxidant capacity, and glutathione level. The activity of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) was significantly elevated. γGC significantly decreased levels of the proinflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β and the activity of the apoptotic marker caspase-3. In addition, γGC reduced kidney lead content, enhanced weight gain, and improved renal function as demonstrated by reduced serum levels of urea and creatinine. Importantly, γGC upregulated proliferating cell nuclear antigen (PCNA) expression, denoting enhanced renal regenerative capacity. Together, our findings highlight evidence for alleviating effects of γGC against lead-induced renal injury that is potentially mediated through diminution of oxidative tissue injury, reduction of inflammatory response, attenuation of apoptosis, and enhancement of renal regenerative capacity.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Salama SA,Arab HH,Maghrabi IA,Hassan MH,AlSaeed MSdoi
10.1007/s12011-016-0624-4subject
Has Abstractpub_date
2016-09-01 00:00:00pages
96-107issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-016-0624-4journal_volume
173pub_type
杂志文章abstract：:Accumulation of lanthanum oxide nanoparticles (La2O3NPs) in the femur bone of rats after 30 days of oral administration was explored. Also, the influence of La2O3NPs on macro and trace elements in the rats' femur bone was assessed. Inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma op...
journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-8025-3
更新日期：2007-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992700
更新日期：1990-07-01 00:00:00
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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doi：10.1007/BF02784557
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journal_title：Biological trace element research
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pub_type： 杂志文章
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0557-3
更新日期：2016-07-01 00:00:00
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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更新日期：2020-09-22 00:00:00
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：1981-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
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journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-009-8486-7
更新日期：2010-06-01 00:00:00
