Abstract：
:Lead (Pb)-induced reproductive toxicity is a well-characterized adverse effect associated with this heavy metal. It has been found that Pb exposure is associated with altered spermatogenesis, increased testicular degeneration, and pathological sperm alterations. On the other hand, it has been reported that Pb-induced reproductive toxicity is associated with increased reactive oxygen species (ROS) formation and diminished antioxidant capacity in the reproductive system. Hence, administration of antioxidants as protective agents might be of value against Pb-induced reproductive toxicity. This study was designed to investigate whether carnosine (CAR) and histidine (HIS) supplementation would mitigate the Pb-induced reproductive toxicity in male rats. Animals received Pb (20 mg/kg/day, oral, 14 consecutive days) alone or in combination with CAR (250 and 500 mg/kg/day, oral, 14 consecutive days) or HIS (250 and 500 mg/kg/day, oral, 14 consecutive days). Pb toxicity was evident in the reproductive system by a significant increase in tissue markers of oxidative stress along with severe histopathological changes, seminal tubule damage, tubular desquamation, low spermatogenesis index, poor sperm parameters, and impaired sperm mitochondrial function. It was found that CAR and HIS supplementation blunted the Pb-induced oxidative stress and mitochondrial dysfunction in the rat reproductive system. Thereby, antioxidative and mitochondria-protective properties serve as primary mechanisms for CAR and HIS against Pb-induced reproductive toxicity.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Ommati MM,Jamshidzadeh A,Heidari R,Sun Z,Zamiri MJ,Khodaei F,Mousapour S,Ahmadi F,Javanmard N,Shirazi Yeganeh Bdoi
10.1007/s12011-018-1358-2subject
Has Abstractpub_date
2019-01-01 00:00:00pages
151-162issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-018-1358-2journal_volume
187pub_type
杂志文章abstract：:The k0 standardization method was adapted for NAA with stable low-flux reactors where flux monitors are not needed. The modified k0 method offers the convenience of the use of libraries of sensitivity constants. It was compared to the relative method for 52 elements using a SLOWPOKE reactor and 6 counting geometries. ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784232
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abstract：:This study evaluated dental fluorosis of the incisors and immunoreactivity in the brain tissues of rats given chronic fluoride doses pre- and postnatally. Female rats were given drinking water with 0, 30 or 100 ppm fluoride ad libitum throughout gestation and the nursing period. In addition, 63 male offspring were tre...
journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
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abstract：:Synaptosomes are used as an ex vivo model in the investigation of neuronal transmission and neurodegenerative processes. In this study, we aimed to determine the protective effects of boric acid (BA) and curcumin, which have antioxidant and anti-inflammatory properties, on Aβ1-42 induced neurodegenerative damage. Syna...
journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02925450
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02796687
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abstract：:In the present study, aluminum (Al) accumulation has been examined after aluminum loading in mice. The kidney, liver, and brain aluminum levels for mice that had been treated orally with aluminum hydroxide for 105 d and for the control group were determined using graphite furnace atomic absorption spectrophotometry (G...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917223
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journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
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更新日期：2011-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0861-6
更新日期：2017-05-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02796677
更新日期：1987-04-01 00:00:00
abstract：:Differences in mineral nutrient composition of soils have been considered to affect health and population characteristics of free-ranging animals, particularly herbivores. Contents of Ca, Mg, and K in hair of female fawn white-tailed deer (Odocoileus virginianus) were measured for eight consecutive years to determine ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783968
更新日期：1998-06-01 00:00:00
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journal_title：Biological trace element research
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doi：10.1007/s12011-010-8769-z
更新日期：2011-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784212
更新日期：1999-01-01 00:00:00
abstract：:In present study, the levels of some toxic elements in 19 different home-made cosmetic products (spray hair dye, henna, tattoo, eyeliner, eye mascara, smear, lip moisturizer, and lipstick) were analyzed by inductively coupled plasma mass spectrometric (ICP-MS) after microwave digestion. The ICP-MS results were verifie...
journal_title：Biological trace element research
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doi：10.1007/s12011-020-02357-8
更新日期：2020-09-05 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789461
更新日期：1996-05-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Biological trace element research
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更新日期：2011-07-01 00:00:00
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abstract：:Changes in the macro and trace element composition of saliva might be indicative for pathological changes in periodontal tissues. However, there is a lack of evidence in the literature showing associations between mineral elements and periodontal status. The aim of this study was to determine whether such associations...
journal_title：Biological trace element research
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journal_title：Biological trace element research
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更新日期：2011-12-01 00:00:00
abstract：:The aim of this study was to evaluate the impact of three different chromium forms--chromic chloride (CrCl3), chromium picolinate (CrPic), and a newly synthesized complex of chromium chelated with small peptides (CrSP)--on protein metabolism in vitro. In cultured skeletal muscle cells, CrSP was able to increase the ba...
journal_title：Biological trace element research
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journal_title：Biological trace element research
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abstract：:Cadmium concentrations were determined in the hair of 226 school children in an industrial and in a rural area of Tarragona Province (NE Spain). The influence of sex, age, hair color, smoking habits of the household members, and parents' occupation on the children's hair cadmium levels was also evaluated. Children liv...
journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：1991-02-01 00:00:00
abstract：:The characteristics of aluminum and chromium binding to apo-transferrin (apo-tf) have been investigated and compared. Both metal ions were taken up by human transferrin forming complexes with the maximum absorbances at 405 nm for chromium-transferrin (cr-tf) and 240 nm for aluminum-transferrin (Al-tf). In the presence...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784585
更新日期：1992-01-01 00:00:00
