Abstract：
:This study evaluated dental fluorosis of the incisors and immunoreactivity in the brain tissues of rats given chronic fluoride doses pre- and postnatally. Female rats were given drinking water with 0, 30 or 100 ppm fluoride ad libitum throughout gestation and the nursing period. In addition, 63 male offspring were treated with the same water regimens as the mothers after weaning and were followed for 1, 3 or 5 months. The upper and lower incisors were collected, and all teeth were examined under a stereomicroscope and scored by two blinded examiners using a modified rodent enamel fluorosis index. Cortical, hippocampal and cerebellar brain samples were evaluated morphologically and immunohistochemically. All fluoride-treated pups were born with low body weight (p = 0.001). All animals from the fluoride groups had enamel fluorosis with defects of various degrees. The increase in the dental fluorosis scores in the fluoride treatment groups was significant (p < 0.01). The catalase immunoreactivity in the 30- and 100-ppm fluoride groups was significantly higher than that in the controls after 1, 3 and 5 months (p < 0.001). In conclusion, this study showed that rats with dental fluorosis had catalase immunoreactivity in the brain tissues, which may reflect the neurobehavioral toxicity of fluoride.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Güner Ş,Uyar-Bozkurt S,Haznedaroğlu E,Menteş Adoi
10.1007/s12011-016-0695-2subject
Has Abstractpub_date
2016-11-01 00:00:00pages
150-157issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-016-0695-2journal_volume
174pub_type
杂志文章abstract：:Selenium (Se) mainly performs its function through Se-containing proteins. Selenoprotein W (SelW), one member of the selenoprotein family, plays important roles in the normal function of the heart. To investigate the possible relationship between Se and SelW for the regulation of oxidative damage in chicken embryo myo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0529-7
更新日期：2016-06-01 00:00:00
abstract：:Arsenic (As), antimony (Sb), and bismuth (Bi) are metalloids that share similar chemical properties, the objective of this study was to characterize the uptake and accumulation of these metalloids by plants colonized on heavy contaminated sites in an old Sb mine. Sixty-five plant samples from seven species as well as ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9017-x
更新日期：2011-12-01 00:00:00
abstract：:Breast milk is considered the best source of nutrition for all infants. However, exposure of newborns to toxic metals is of special interest due to their potential harmful effects. Thus, the primary aims of this study were to determine the concentration of toxic heavy metals including lead, mercury, cadmium, and bariu...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1355-5
更新日期：2019-01-01 00:00:00
abstract：:Guizhou black goats are essential to the production system in the Wumeng prairie in the Western China. This study aimed to determine the influence of nano-copper on antioxidant system in copper-deprived Guizhou black goats. We analyzed mineral contents in soil, forage, and goats' tissues. Blood parameters were also de...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02342-1
更新日期：2020-08-18 00:00:00
abstract：:The efficacy of selenate and other divalent anions to stimulate the efflux of radiolabeled sulfate from lactating rat mammary tissue slices has been examined. Both selenate and sulfate markedly increased the fractional release of sulfate via a system that is temperature-sensitive and sensitive to the anion-exchange in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917205
更新日期：1990-03-01 00:00:00
abstract：:The objective of the study was to evaluate the maximum tolerance limit of amino acid copper complex (Cu-Lys-Glu) for laying hens by measuring their laying performance, hematological and serum biochemical parameters, organ index, and histopathology. A total of 450 18-week-old Beijing White layers were randomly allocate...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02406-2
更新日期：2020-10-12 00:00:00
abstract：:The aim of this study was to compare zinc, copper, lead, cadmium, and mercury concentrations in the bones of long-living mammals-humans (Homo sapiens) and Canidae (dogs Canis familiaris and foxes Vulpes vulpes) from northwestern Poland and to determine the usefulness of Canidae as bioindicators of environmental exposu...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9615-x
更新日期：2013-05-01 00:00:00
abstract：:A simple, eco-friendly, green routine co-precipitation method was experimented to synthesize iron nanoparticles (Fe-NPs) using the cell-free supernatant of actinobacteria. The biosynthesized nanoparticles were characterized by UV-Vis spectroscopy, X-ray diffractometer (XRD), energy-dispersive X-ray (EDX), scanning ele...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01777-5
更新日期：2020-03-01 00:00:00
abstract：CONTEXT:Complementary alternative medicine therapies based on the use of cesium chloride preparations for the treatment of cancer and radiation poisoning, have generated therapeutic interest; but oral or intravenous administration of cesium chloride (CsCl) to cancer patients as an alternative mode of cancer therapy hav...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:94:2:97
更新日期：2003-08-01 00:00:00
abstract：:The purpose of the present study was to measure the pattern of uptake of(75)Se into proteins in normal rat lenses and into the proteins of lenses with selenite-induced cataract. Ten-day-old suckling rats received a single injection of(75)Se with or without a cataractous dose of cold carrier sodium selenite. Four days ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917506
更新日期：1984-06-01 00:00:00
abstract：:The purpose of this research was to investigate whether copper (Cu) exposure could induce apoptosis via endoplasmic reticulum stress (ERS) in skeletal muscle of broilers. A total of 240 one-day-old chickens were randomly divided into four groups by free access; the diets are as follows: control diet (Cu 11 mg/kg, cont...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02076-0
更新日期：2020-12-01 00:00:00
abstract：:Deficiencies in Cu, Se, and Zn impair one or more biochemical functions, and excess are associated with toxicity. Baseline studies on the Ghanaian population are scanty. The study was undertaken to determine whether significant rural/urban differences in the serum levels of Cu, Se, and Zn did exist. Forty males/60 fem...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8571-y
更新日期：2010-11-01 00:00:00
abstract：:Rare earth elements (REEs) have been widely used to increase accumulation of biomass and secondary metabolites in medicinal plants in China. However, very few studies have investigated how REEs mediate secondary metabolism synthesis in medicinal plants. Lanthanum (La), an important REE, is known to improve the accumul...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9379-8
更新日期：2012-09-01 00:00:00
abstract：:This study evaluated the plasma levels of trace elements in children with chronic hepatitis B virus (HBV) infection and assessed whether they can be a factor that affects the response to interferon alpha (IFN-alpha) treatment. The study included 35 cases (ten girls, 25 boys) aged 3-13 years with chronic HBV infection ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8507-6
更新日期：2010-06-01 00:00:00
abstract：:In the present study, we investigated the effects of lycopene on the expression of organic anion transporters (OATs), organic cation transporters (OCTs), and multidrug resistance-associated proteins (MRPs) of cisplatin-induced nephrotoxicity in rats. Twenty-eight 8-week-old Wistar rats were divided into four groups: c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9914-x
更新日期：2014-04-01 00:00:00
abstract：:Zinc uptake regulator (Zur) is a negative transcriptional regulator of bacteria that belongs to the FUR superfamily of proteins and regulates zinc (Zn) homeostasis under extreme Zn conditions. The Zur protein of Bacillus anthracis (BaZur) was though characterized previously, but the residues of this transcriptional re...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02427-x
更新日期：2020-10-14 00:00:00
abstract：:The association between serum copper and zinc concentrations and age, sex, and other risk factors of cardiovascular disease in randomly selected adult volunteers aged 19-59 were investigated. There was a positive relationship between copper and age in both sexes, but zinc was negatively correlated with age in males on...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02950795
更新日期：1994-03-01 00:00:00
abstract：:The movement of copper and zinc from the fertilized egg into the developing embryo and the subsequent association of the two metals with metallothionein-like proteins (MT) of chick liver was investigated. Hepatic levels of MT in 1-d-old chicks, estimated from specifically bound(115m)Cd, were increased eightfold over e...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02988942
更新日期：1983-12-01 00:00:00
abstract：:The present study investigated the role of kisspeptin-10 on reproductively significant trace elements in relation to testosterone release in male rabbits, Oryctolagus cuniculus. Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9720-x
更新日期：2013-08-01 00:00:00
abstract：:Two experiments were conducted to study the performance, antioxidant activity, and bone mineral variables in broilers fed organic trace minerals (OTM) at lowered concentrations in the diet. In experiment 1, a total of 1500 day-old broiler male chicks were randomly distributed into six groups with 10 replicates of 25 c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02481-5
更新日期：2020-11-20 00:00:00
abstract：:In the present study, aluminum (Al) accumulation has been examined after aluminum loading in mice. The kidney, liver, and brain aluminum levels for mice that had been treated orally with aluminum hydroxide for 105 d and for the control group were determined using graphite furnace atomic absorption spectrophotometry (G...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917223
更新日期：1994-04-01 00:00:00
abstract：:Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1077-0
更新日期：2018-03-01 00:00:00
abstract：:We analyzed the effects of acute and chronic oral administration of monosodium L-glutamate (MSG) on serum iron (Fe) levels and total iron-binding capacity (TIBC) in piglets. In the first experiment, 12 piglets were randomly assigned to two groups: one fed a standard diet (SD) and the other fed an SD containing MSG (10...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9668-x
更新日期：2013-06-01 00:00:00
abstract：:Chronic copper exposure impaired spermatogenesis in adult male mice. The aim of this study was to determine whether chronic copper exposure can induce apoptosis of testicular cell and hypospermatogenesis via disturbing testosterone synthesis in adult male mice. In the present study, sixty CD-1 male mice were randomly ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01852-x
更新日期：2020-06-01 00:00:00
abstract：:Cadmium (Cd) exposure has been recognized to result in a wide variety of cellular responses, including oxidative stress and body weight loss. The aim of the present study was to examine the effect of lycopene supplementation on the antioxidant defense system, lipid peroxidation (LPO) level, nitric oxide (NO), tumor ne...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0027-7
更新日期：2007-08-01 00:00:00
abstract：:Zinc, copper, and selenium statuses were reported to be linked to the development of chronic diseases, especially coronary heart disease (CHD). Metabolic syndrome, a known CHD risk factor, was found to be highly prevalent in Lebanon. Nevertheless, no data are available on the statuses of plasma zinc, copper, and selen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8112-0
更新日期：2008-07-01 00:00:00
abstract：:The study was undertaken to investigate the influence of alpha-tocopherol on zinc, copper, iron, calcium, magnesium, and potassium concentrations in serum of rats with bleomycin-induced pulmonary fibrosis. Fourteen Wistar albino rats were randomly divided into two groups of seven animals each. The first group was trea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:114:1:175
更新日期：2006-01-01 00:00:00
abstract：:Iodine, an essential micronutrient, is required to produce thyroid hormones. Iodine deficiency disorders (IDD) comprise a range of adverse maternal and fetal outcomes, with the most significant irreversible effect resulting from neurodevelopmental deficits in fetal brain caused by deficient iodine status during early ...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-018-1606-5
更新日期：2019-03-01 00:00:00
abstract：:Plasma chromium concentrations have been determined for 150 patients. These were subjected to coronary artery cineangiography and thereby divided into three groups: group CAD (those with coronary artery disease), group HD (those with heart disease, but no CAD) and group N (those with no CAD and no HD). Weighted, avera...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02989260
更新日期：1984-10-01 00:00:00
abstract：:The small intestine is one of the target organs of dietary selenium (Se) deficiency. Our objective was to investigate the effects of Se deficiency on small intestinal mucosa morphology and function in chickens. In the present study, 1-day (d)-old chickens were fed either a commercial diet with 0.15 mg/kg Se (control g...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-02017-6
更新日期：2020-10-01 00:00:00
