Abstract：
:The study was undertaken to investigate the influence of alpha-tocopherol on zinc, copper, iron, calcium, magnesium, and potassium concentrations in serum of rats with bleomycin-induced pulmonary fibrosis. Fourteen Wistar albino rats were randomly divided into two groups of seven animals each. The first group was treated intratracheally with bleomycin hydrochloride (BM group); the second group was also instilled with BM but received injections of alpha-tocopherol twice a week (BM+E group). The third group was treated in the same manner with saline solution only, acting as controls (C). The zinc concentrations of the BM and BM+E groups were significantly decreased compared to the controls (p<0.05). The iron concentration of the controls was significantly higher than the other two groups. The magnesium concentration in the controls and the BM+E group was significantly higher than that of the BM group. The serum copper, calcium, and potassium concentrations were not found to be statistically different among the three groups. Distinct histopathologic changes were found in the BM group compared to the untreated rats. Less severe fibrotic lesions were also observed in the BM+E group. The results of this study show that lungs of rats treated with bleomycin were seriously damaged and that vitamin E seemed to counteract some of the damage, as indicated by differences in the serum concentrations of major elements.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Dede S,Mert H,Mert N,Yur F,Ertekin A,Deger Ydoi
10.1385/BTER:114:1:175subject
Has Abstractpub_date
2006-01-01 00:00:00pages
175-84issue
1-3eissn
0163-4984issn
1559-0720pii
BTER:114:1:175journal_volume
114pub_type
杂志文章abstract：:Six important metal contents (i.e., zinc, barium, magnesium, calcium, copper, and selenium) in blood samples coupled with an ensemble classification algorithm have been used for the classification of normal people and cancer patients. A dataset containing 42 healthy samples and 32 cancer samples was used for experimen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8864-1
更新日期：2011-10-01 00:00:00
abstract：:The current information about the effect of physical exercise on the body concentrations of several minerals is still limited, both in the acute (short-term) and adaptive (long-term) responses. So, this manuscript aims, on the one hand, to assess the possible differences on basal levels of cobalt (Co), copper (Cu), an...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-018-1500-1
更新日期：2019-06-01 00:00:00
abstract：:Cadmium (Cd) is an environmental toxicant and an inflammation-related xenobiotic. Selenium (Se) is a well-known nutritional trace element and a potent chemopreventive agent. The present study aimed to investigate the effect of Se on the cytotoxicity of Cd in bird immunocytes in vitro. Chicken splenic lymphocytes expos...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0354-z
更新日期：2015-11-01 00:00:00
abstract：:The decline in fish population because of water contamination is problem. As a result of direct exposure in water, it has been readily accepted that the gills are the main site of water contamination and toxicity (e.g., metal ions). In the present study, we investigated metal ion contamination on the functional capaci...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:100:3:229
更新日期：2004-09-01 00:00:00
abstract：:Deficiency in the intake of trace elements, such as copper (Cu), iron (Fe), selenium (Se), and zinc (Zn), is very common in the general population of most developing countries. A preliminary study in India and Pakistan showing the plasma levels of Zn and Fe indicates that approx 50% of the subjects who participated ha...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789092
更新日期：1998-03-01 00:00:00
abstract：:The growth of the protozoan Blepherisma is stimulated by Lanthanum (La) at concentrations as low as 0.32 ppm. In mice Yttrium (Y) and Ytterbium (Yb) are absorbed, accumulated, and metabolized. Both rare earth elements (RE) exhibit a high affinity for teeth and bones, accumulation occurs and metabolism is slow. In the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795448
更新日期：1988-09-01 00:00:00
abstract：:The present investigation was carried out to determine the molybdenum (Mo) status of blood plasma and milk of lactating cows at the Livestock Experimental Station, Khizer abad, Sargodha, Pakistan. Blood and milk from the lactating cows were sampled periodically after every month during winter so as to examine the effe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8874-z
更新日期：2011-10-01 00:00:00
abstract：:Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric disturbances and may arise from an impaired or not fully developed excretion system, transporter malfunction and/or exposure to excessive levels of Mn. Therefore, dec...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1531-7
更新日期：2019-03-01 00:00:00
abstract：:This study was performed with the aim of investigating the concentration of zinc and copper in the blood of healthy alpacas (Vicugna pacos) kept in central Europe and to compare the concentration of Zn and Cu in plasma and in whole blood. A further objective was to evaluate blood Zn and Cu in relation to different mic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1043-x
更新日期：2018-02-01 00:00:00
abstract：:An "anti-oxidant cocktail" consisting of betacarotene, vitamins B6, C, E, zinc, and selenium or corresponding placebos were given for one y as daily dietary supplements to 45 elderly residents of a nursing home. Initially, the serum TBA reactant levels were higher (2.7 +/- 0.7 mumol/L) than those of an ad hoc control ...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/BF02795458
更新日期：1988-09-01 00:00:00
abstract：:The effect of ad libitum ingestion of selenium (Se) in drinking water (0.15 mg SeO2/L) for 3 wk on the brain weight, total brain protein, glutathione (GSH) level, catalase activity, and lipid peroxidation in the brain of protein-undernourished (PU) rats was investigated, in an attempt to determine whether antioxidants...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02685933
更新日期：2007-05-01 00:00:00
abstract：:Calcium, magnesium, and zinc balances were determined in eleven young adult college females (mean age, 24.9±2.35) during a 39-d metabolic study when the subjects were fed an adequate calorie and protein diet based on habitually consumed foods. Analysis showed that the dietary contribution of calcium, magnesium, and zi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917454
更新日期：1985-11-01 00:00:00
abstract：:The degree of chromosome damage induced by three compounds of zinc (zinc chloride, zinc sulfate, zinc acetate) was compared in human leucocytes in vitro. Three concentrations of each salt, 3.0 x 10(-5)M, 3.0 x 10(-4)M, and 1.5 x 10(-3)M, were added to leukocyte cultures. The cells were harvested after 48 and 72 h and ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:78:1-3:113
更新日期：2000-01-01 00:00:00
abstract：:The consumption of vegetables grown on soils polluted by trace elements can cause a serious threat for animal and human health and disturb the functioning of the ecosystem. The aim of this work is to determine the concentrations of As, Cd, Co, Cr, Cu, Ni, Pb, Mn, and Zn in soils and different vegetables from market ga...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01849-6
更新日期：2020-05-01 00:00:00
abstract：:A simple, eco-friendly, green routine co-precipitation method was experimented to synthesize iron nanoparticles (Fe-NPs) using the cell-free supernatant of actinobacteria. The biosynthesized nanoparticles were characterized by UV-Vis spectroscopy, X-ray diffractometer (XRD), energy-dispersive X-ray (EDX), scanning ele...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01777-5
更新日期：2020-03-01 00:00:00
abstract：:Nickel is an important kind of metal and a necessary trace element in people's production and livelihood; it is also a well-confirmed human carcinogen. In the past few years, researchers did a large number of studies about the molecular mechanisms of nickel carcinogenesis, and they focused on activation of proto-oncog...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9619-6
更新日期：2013-05-01 00:00:00
abstract：:The effects of cadmium on the growth rate, catalase activity, and peroxisome proliferation in yeast, Candida albicans, were evaluated. The yeast growth was markedly inhibited by 1 mM cadmium at the initial hours. The toxic effect of cadmium on the cell growth persisted. The catalase activity of the cells treated with ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789415
更新日期：1995-11-01 00:00:00
abstract：:The purpose of the present study was to measure the pattern of uptake of(75)Se into proteins in normal rat lenses and into the proteins of lenses with selenite-induced cataract. Ten-day-old suckling rats received a single injection of(75)Se with or without a cataractous dose of cold carrier sodium selenite. Four days ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917506
更新日期：1984-06-01 00:00:00
abstract：:The effects of nutritional copper deficiency on carrageenin edema in the rat were investigated with emphasis on studying the correlation between the degree of copper deficiency and the degree of edema. Carrageenin paw edema in both copper-sufficient and copper-deficient groups of rats was compared after either 20, 40,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917181
更新日期：1989-01-01 00:00:00
abstract：:Selenium concentrations in the blood of 112 (56 females and 56 males) normal subjects, from different regions of the Punjab (Pakistan), have been determined using the technique of inductively coupled plasma-mass spectrometry. The whole blood selenium concentrations were found to be 452 ± 12 ppb (parts per billion or n...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8867-y
更新日期：2011-10-01 00:00:00
abstract：:The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, so...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:80:1:53
更新日期：2001-04-01 00:00:00
abstract：:The present work aimed at assessing passive, innate, and acquired immunity in piglets from sows supplemented with either organic or inorganic selenium (Se). A total of 12 multiparous pregnant sows were randomly allocated to three groups: selenium-deficient, corn and soy-based diet base diet (BD), 0.3 mg Se/kg as hydro...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01754-y
更新日期：2020-03-01 00:00:00
abstract：:Issues regarding biomagnification of mercury (Hg) due to its persistence, bioaccumulation, and toxicity in freshwater lakes have gained much attention in the last two decades especially in remote regions of the world where anthropogenic inputs are considered as negligible. In this study, spatial distribution of total ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02479-z
更新日期：2021-01-07 00:00:00
abstract：:Tungstate is an oxyanion that has biological similarities to vanadate. In recent years, a number of studies have shown the antidiabetic effects of oral tungstate in animal models of diabetes. However, because of the tissue accumulation and potential toxicity derived from chronic administration of vanadium and tungsten...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1385/BTER:88:2:097
更新日期：2002-08-01 00:00:00
abstract：:The metabolic significance of Se in plants is not well documented, though the presence of many selenoenzymes in bacteria and the essentiality of Se in higher animals is established. Since germination is an active process in plant growth and metabolism, the effect of Se was investigated in germinating Vigna radiata L, ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789188
更新日期：1995-05-01 00:00:00
abstract：:Modifications in the enzyme activity of lysozyme, a protein implied in the defence barrier of the organism, can be a good biomarker of alterations in the immune system as a result of exposure to toxic metal, such as lead. The aim of this work was to evaluate the effect of a 200 ppm dose of lead on lysozyme activity in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9446-1
更新日期：2012-12-01 00:00:00
abstract：:The effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using Akt2 and IRS1 gene expression methods in streptozotocin-induced diabetic rats. Fifty rats were randomly divided into five experimental groups: 1, non-diabetic control (NDC); 2, Mg2+-treated non-diabet...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1555-z
更新日期：2019-08-01 00:00:00
abstract：:Assessment of trace element levels in general population from the specific area is of importance for nutritional and occupational monitoring. In the current study, baseline blood levels of 12 toxic and/or essential metals and metalloids, including arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), chromium (Cr), tha...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1486-8
更新日期：2019-06-01 00:00:00
abstract：:Several epidemiological studies have shown that exposure to electromagnetic radiation (EMR) can be harmful to human health. The purpose of this study was to examine oxidative parameters and apoptosis induced by EMR in human kidney embryonic cells (HEK293) and to investigate whether zinc (Zn) has protective effect on E...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01811-6
更新日期：2020-04-01 00:00:00
abstract：:A series of experiments was conducted to study the effects of dietary and injected lead (as Pb acetate-3H2O) and of dietary Cd, Hg, and Se on fatty acid composition of serum lipids of chicks as measured by gas-liquid chromatography. The effect of dietary Pb on fatty acid composition of erythrocyte membranes was measur...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02989250
更新日期：1985-06-01 00:00:00
