Abstract：
:This study was performed with the aim of investigating the concentration of zinc and copper in the blood of healthy alpacas (Vicugna pacos) kept in central Europe and to compare the concentration of Zn and Cu in plasma and in whole blood. A further objective was to evaluate blood Zn and Cu in relation to different micromineral supplementation, age and sex groups of alpacas. A total of 299 alpacas (224 adults and 75 crias) from 18 farms were included in this study. The concentrations of copper and zinc in plasma/whole blood were measured by flame atomic absorption spectrometry. The results of this study show high individual variability in plasma Zn (median 3.54, range 1.56-8.01 μmol/l), whole blood Zn (median 10.01, range 6.23-75.0 μmol/l), plasma Cu (median 7.53, range 2.93-16.41 μmol/l) and whole blood Cu (median 6.33, range 3.02-13.95 μmol/l). Plasma Zn was not significantly influenced by sex, age or feeding group. Whole blood Zn was only significantly higher in females than in males. The intake of Zn in all groups was equal to or higher than the nutritional recommendation. During excessive supplementation, Zn absorption decreased and thus blood Zn did not reflect the higher intake. Only a weak correlation was found (Spearman correlation coefficient r = 0.384; p > 0.01; n = 204) between plasma and whole blood Zn concentrations. Plasma copper concentration was significantly influenced by age, sex and feeding; whole blood Cu by age and feeding. However, neither plasma Cu nor whole blood Cu reflected the intake of the element. We found a close correlation between plasma and blood copper concentrations (Spearman correlation coefficient r = 0.9043; p ≤ 0.01; n = 99). According to our results, copper in plasma or blood is not a good indicator of copper intake.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Pechová A,Husáková T,Pavlata L,Holasová M,Hauptmanová Kdoi
10.1007/s12011-017-1043-xsubject
Has Abstractpub_date
2018-02-01 00:00:00pages
242-250issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-017-1043-xjournal_volume
181pub_type
杂志文章abstract：:In the present study, spectroscopic determinations of copper ions using chimeric metal-binding green fluorescent protein (His6GFP) as an active indicator have been explored. Supplementation of copper ions to the GFP solution led to a remarkable decrease of fluorescent intensity corresponding to metal concentrations. F...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8476-9
更新日期：2010-06-01 00:00:00
abstract：:In the present study, aluminum (Al) accumulation has been examined after aluminum loading in mice. The kidney, liver, and brain aluminum levels for mice that had been treated orally with aluminum hydroxide for 105 d and for the control group were determined using graphite furnace atomic absorption spectrophotometry (G...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917223
更新日期：1994-04-01 00:00:00
abstract：:The effect of parenteral zinc on tissue metallothionein (MT) was studied in normal and streptozotocin-induced diabetic rats. The accumulation of Zn-MT in liver and pancreas of normal and diabetic rats following the administration (ip) of various amounts of zinc was not different. Renal Zn-MT was higher in the diabetic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795531
更新日期：1986-12-01 00:00:00
abstract：:Hypomagnesemia is associated with the development of neuropathy and abnormal platelet activity, both of which are risk factors for diabetic foot ulcer (DFU). This study was carried out to evaluate the effects of magnesium administration on wound healing and metabolic status in subjects with DFU. This randomized, doubl...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-017-1056-5
更新日期：2018-02-01 00:00:00
abstract：CONTEXT:Complementary alternative medicine therapies based on the use of cesium chloride preparations for the treatment of cancer and radiation poisoning, have generated therapeutic interest; but oral or intravenous administration of cesium chloride (CsCl) to cancer patients as an alternative mode of cancer therapy hav...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:94:2:97
更新日期：2003-08-01 00:00:00
abstract：:The aim of the present study was to investigate the effect of selenium (Se) deficiency on the expression of the toll-like receptor (TLR) signal transduction pathway in the spleen of chickens and explore the relationship between the TLR4/TRIF/NF-κB signaling pathway and inflammatory spleen injury. A total of 200 one-da...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02173-0
更新日期：2021-02-01 00:00:00
abstract：:This paper aims to compare the Cd, Cu, and Pb concentration in the bone, gills, and muscle of the seven fish species sampled during normal and dry seasons. Cadmium, Cu, and Pb concentrations varied significantly depending on the type of the tissue and season. Bone samples of the Osteochilus hasseltii showed the highes...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8596-2
更新日期：2010-12-01 00:00:00
abstract：:The present research evaluated differential effects of sodium selenite and nano-Se on growth performance, tissue Se distribution, and glutathione peroxidase (GSH-Px) activity of avian broiler. Broilers were randomly segregated into 12 groups so that three replicates were available for each of the three treatments (T-1...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8264-y
更新日期：2009-05-01 00:00:00
abstract：:Diabetes is a common metabolic disorder characterized by elevated blood glucose level. Trace element homeostasis causes disturbances in diabetes due to hyperglycemia. Superoxide dismutase (SOD), an antioxidant enzyme, contains zinc and copper ions as its cofactors. Defects in SOD level and activity have been observed ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0861-6
更新日期：2017-05-01 00:00:00
abstract：:Yerba mate (Ilex paraguariensis), a widely consumed beverage in South America, contains various biochemically active substances, among them are several minerals. This paper reports on the results of a survey of trace elements in the yerba mate infusions. Three different commercially available trademarks of I. paraguar...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9056-3
更新日期：2011-12-01 00:00:00
abstract：:Imbalance of zinc and copper status has been hypothesized in human hypertension. A case-control study was carried out to elucidate the possible relationship between zinc and copper status and essential hypertension. Thirty-one subjects affected by mild stable hypertension, pharmacologically untreated, were investigate...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02788959
更新日期：1995-08-01 00:00:00
abstract：:The present work aimed at assessing passive, innate, and acquired immunity in piglets from sows supplemented with either organic or inorganic selenium (Se). A total of 12 multiparous pregnant sows were randomly allocated to three groups: selenium-deficient, corn and soy-based diet base diet (BD), 0.3 mg Se/kg as hydro...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01754-y
更新日期：2020-03-01 00:00:00
abstract：:The effects of cerium oxide nanoparticles on the proliferation, differentiation, and mineralization function of primary osteoblasts in vitro were evaluated. The results showed that the cell biological effects of cerium oxide nanoparticles varied with different diameters. The cytotoxicity of cerium oxide nanoparticles ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9655-2
更新日期：2013-06-01 00:00:00
abstract：:Linolenic acid is an inhibitor of electron transport in chloroplasts of higher plants. It has obvious effects on the structure and function of chloroplasts. In the present paper, we investigated the nano-anatase relieving the inhibition of photoreduction activity and oxygen evolution caused by linolenic acid in spinac...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-8055-x
更新日期：2008-04-01 00:00:00
abstract：:Antioxidants can play a significant role in chronic inflammatory process. The aim of this study was to evaluate the content of selenium (Se), zinc (Zn), copper (Cu), and total antioxidant status (TAS) of patients with chronic tonsillitis (CT). The study group consisted of 84 patients with CT from 18 to 62 years old an...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-016-0634-2
更新日期：2016-09-01 00:00:00
abstract：:Copper is an essential trace element with various biological functions. Excess copper, however, is extremely toxic, leading to many pathological conditions that are consistent with oxidative damage to membranes and molecules. Exposure to high levels of copper results in various changes in the tissues. In liver, hypert...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:96:1-3:209
更新日期：2003-01-01 00:00:00
abstract：:Studies of effects of diazepam on liver parenchyma are very scanty. In this study, adult albino rats were treated with diazepam in two different doses (0.25 mg and 0.30 mg/kg body wt) daily for 30 and 60 d. Through light microscopy and electron microscopy, prenecrotic and necrotic changes were noted in the high-dose g...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785292
更新日期：1997-06-01 00:00:00
abstract：:This study was undertaken to evaluate a systematic analysis of mineral and trace elements of individual functionally determined parts of adult temporal bone. Marked differences were observed in basic structural elements (Ca, P, Mg, and Zn) among different bone regions. The more so, molar Ca/P ratio was significantly d...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF03032672
更新日期：1991-04-01 00:00:00
abstract：:Zinc (Zn) is essential for development, growth, and reproduction. The Mexican government subsidizes micronutrient-fortified milk for risk groups, with positive effect on the targeted groups' plasma Zn level, inferring a good absorption is achieved although it has not being measured. The aim of this study was to determ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0356-x
更新日期：2015-11-01 00:00:00
abstract：:Indigenous preparations (IPs) have evoked a considerable interest in alleviating infections and chronic diseases and improving wellbeing. While such formulations have been a part of traditional practice in several countries and many have been reviewed scientifically for their claims, several of them until date remain ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1411-1
更新日期：2019-04-01 00:00:00
abstract：:Chronic copper exposure impaired spermatogenesis in adult male mice. The aim of this study was to determine whether chronic copper exposure can induce apoptosis of testicular cell and hypospermatogenesis via disturbing testosterone synthesis in adult male mice. In the present study, sixty CD-1 male mice were randomly ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01852-x
更新日期：2020-06-01 00:00:00
abstract：:Organotin compounds are highly versatile group of organometallic chemicals used in industrial and agricultural applications. Their endocrine-disrupting effects are well known and their extensive uses as biocide materials, e.g., in antifouling paints, for many years have led to serious environmental problems. So far, a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0144-z
更新日期：2014-12-01 00:00:00
abstract：:The aim of this study was to evaluate the impact of three different chromium forms--chromic chloride (CrCl3), chromium picolinate (CrPic), and a newly synthesized complex of chromium chelated with small peptides (CrSP)--on protein metabolism in vitro. In cultured skeletal muscle cells, CrSP was able to increase the ba...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8579-3
更新日期：2010-11-01 00:00:00
abstract：:Tomato quality and its potential health benefits are directly related to its chemical composition. The characterization of nutritional properties of Solanum germplasm is essential to choose suitable donor parents for breeding programs. In this sense, wild species could be very useful for tomato fruit quality genetic i...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8738-6
更新日期：2011-06-01 00:00:00
abstract：:Nano-titanium dioxide is a kind of widely used nanomaterial that exhibits various adverse outcomes. However, the role of oxidative stress in this regard remains controversial. This study aimed to evaluate whether oxidative stress is one of the toxicity mechanisms induced by nano-titanium dioxide in rats and mice model...
journal_title：Biological trace element research
pub_type： 杂志文章,meta分析
doi：10.1007/s12011-019-01761-z
更新日期：2020-03-01 00:00:00
abstract：:To reveal the role of key elements present in the hair of breast cancer patients on cancer development, the levels of a number of elements in scalp hair samples of 82 people including healthy individuals, people suffering from benign breast disease, and breast cancer patients were measured by PIXE analysis. Pellets of...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9671-2
更新日期：2013-06-01 00:00:00
abstract：:The movement of copper and zinc from the fertilized egg into the developing embryo and the subsequent association of the two metals with metallothionein-like proteins (MT) of chick liver was investigated. Hepatic levels of MT in 1-d-old chicks, estimated from specifically bound(115m)Cd, were increased eightfold over e...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02988942
更新日期：1983-12-01 00:00:00
abstract：:It has been shown recently that Selenium (Se), an essential trace element for humans, is involved in the regulation of thyroid function, since the enzyme that catalyzes the liver conversion of the thyroid hormone T4 to the more active form T3 is a selenoenzyme. In chronic uremic patients, low blood Se levels as well a...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02785281
更新日期：1996-12-01 00:00:00
abstract：:The purpose of this study was to analyze the existing studies and to investigate the relationship between children's full-scale intelligence quotient (FIQ), verbal IQ (VIQ), and performance IQ (PIQ) and their blood lead (Pb) and zinc (Zn) levels. All documents in Chinese and English were collected from the PubMed, Web...
journal_title：Biological trace element research
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12011-017-1093-0
更新日期：2018-04-01 00:00:00
abstract：:Trace element contamination in Chinese herbal medicines has been recognized as a potential health concern for consumers. To assess the health risk to the herb-consuming population, nine trace elements (Cu, Cd, Cr, Mo, Ni, Pb, Sr, Zn, and As) were investigated based on their concentrations in three common medicinal pla...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02539-4
更新日期：2021-01-03 00:00:00
