Feasibility of breast cancer screening by PIXE analysis of hair.

Abstract:

:To reveal the role of key elements present in the hair of breast cancer patients on cancer development, the levels of a number of elements in scalp hair samples of 82 people including healthy individuals, people suffering from benign breast disease, and breast cancer patients were measured by PIXE analysis. Pellets of hair samples were prepared and bombarded by 2.2 MeV proton beam of a 3-MV Van de Graaff accelerator. The number of incident ions hitting the sample was indirectly measured using the RBS spectrum of a thin Ag film placed in the beam path. The concentrations of S, Cl, K, Ca, Fe, and Cu in the hair of healthy individuals were in agreement with those observed in the hair of hyperplasia and cancer patients within standard deviations. However, a lower average level of zinc was found in samples from hyperplasia and breast cancer patients. Strong positive correlations were found between iron and potassium as well as between calcium and potassium in the cancer patients. These results could be of significance in the screening for breast cancer.

journal_name

Biol Trace Elem Res

authors

Gholizadeh N,Kabiri Z,Kakuee O,Saleh-Kotahi M,Changizi V,Fathollahi V,Oliaiy P,Omranipour R

doi

10.1007/s12011-013-9671-2

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

105-10

issue

1-3

eissn

0163-4984

issn

1559-0720

journal_volume

153

pub_type

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