Biochemical response to colloidal bismuth subcitrate: dose-time effect.

Abstract:

:In the present study, an investigation was undertaken to assess the efficacy on serum enzymes of colloidal bismuth subcitrate (CBS). CBS was administered with injections to male rats in 100-, 200-, 400-, 500-, and 1000-microg/L doses of bismuth. Rats were anesthetized at different intervals (24, 48, and 72 h) after CBS injections. The levels of serum enzymes were determined. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and creatine kinase (CK) levels significantly increased after all CBS treatments without dependence on time. All doses of bismuth significantly affected the lactate dehydrogenase (LDH) in serum after 72 h. The lowest doses were the most toxic on ALT and LDH. These data suggest that treatment with CBS can provide evidence for a possible marker of liver toxicity although there is no evidence of liver accumulation of bismuth in the present study.

journal_name

Biol Trace Elem Res

authors

Türkez H,Geyikoğlu F,Keleş MS

doi

10.1385/BTER:105:1-3:151

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

151-8

issue

1-3

eissn

0163-4984

issn

1559-0720

pii

BTER:105:1-3:151

journal_volume

105

pub_type

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