Abstract：
:The binding of Cu(II), Zn(II), Ni(II), and Cd(II) to protein components in serum, placenta, kidney, and urine was investigated at physiological pH, using radioisotopes as tracers. All the four metals were bound to albumin and other macromolecules in serum. However, small amounts were also bound to low molecular weight components of the size 1500-10000 daltons. The nature of the Cu(II)-binding to alpha-fetoprotein suggests its important role as the Cu(II)-transporting protein in fetal life. Metal binding to placental components were studied using both rat placenta and isolated human trophoblast cells. Studies of metal binding targets in kidney resulted in the isolation of a 4000 daltons acidic polypeptide which binds Ni(II) and Cd(II) with Kapp = 1.1 x 10(-5) and 2.3 x 10(-5), respectively. Studies of metal binding substances in urine reveals the major amounts of these metals binding to substances of molecular weight 500-5000 daltons. Preliminary amino acid analysis suggests these components rich in acidic amino acids, similar to what has been found with kidney polypeptide. There may be a general role for such compounds in the handling of metals in the process of excretion.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Sarkar Bdoi
10.1007/BF02917246subject
Has Abstractpub_date
1989-07-01 00:00:00pages
137-44eissn
0163-4984issn
1559-0720journal_volume
21pub_type
杂志文章abstract：:Garlic (Allium sativum) is known to reduce lead toxicity in some species of animals. The objective of this study was to evaluate the efficacy of allicin, one of the most active components of garlic, in the treatment of subacute lead intoxication in sheep. Nine female sheep weighing 25-29 kg orally received a daily dos...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8185-9
更新日期：2008-01-01 00:00:00
abstract：:The effects of nutritional copper deficiency on carrageenin edema in the rat were investigated with emphasis on studying the correlation between the degree of copper deficiency and the degree of edema. Carrageenin paw edema in both copper-sufficient and copper-deficient groups of rats was compared after either 20, 40,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917181
更新日期：1989-01-01 00:00:00
abstract：:To better understand the relationship between prenatal exposure to heavy metals and trace elements and the risk of adverse pregnancy outcomes, we investigated the status of heavy metals and trace elements level in a Chinese population by collecting umbilical cord blood. Umbilical cord blood heavy metals and trace elem...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0057-x
更新日期：2014-09-01 00:00:00
abstract：:The objective was to determine if a mammary cell line shows glucocorticoid stimulation of Zn uptake, and to determine whether polyamines mediate this stimulation. 65Zn uptake by COMMA-1D mouse mammary epithelial cells over a 24-h period increased significantly in cells administered 10(-7) or 10(-6) M hydrocortisone. I...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783193
更新日期：1993-11-01 00:00:00
abstract：:The growth of the protozoan Blepherisma is stimulated by Lanthanum (La) at concentrations as low as 0.32 ppm. In mice Yttrium (Y) and Ytterbium (Yb) are absorbed, accumulated, and metabolized. Both rare earth elements (RE) exhibit a high affinity for teeth and bones, accumulation occurs and metabolism is slow. In the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795448
更新日期：1988-09-01 00:00:00
abstract：:After considering the need for quality control in NAA, the concept of quality in NAA procedures themselves is discussed, and some important factors identified. Two approaches to improve quality are then described in more detail. The first concerns the unique ability of NAA using different isotopic reactions and differ...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02917356
更新日期：1994-10-01 00:00:00
abstract：:Plasma and erythrocyte lipid peroxidation levels of 20 patients with histopathologically confirmed testis cancer and 20 healthy control individuals were studied between November 1995 and June 1997. The group with testis cancer had a mean age of 24.8+/-8.2 yr and the control group's mean age was 28.3+/-6.9 yr. Stage di...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:73:2:181
更新日期：2000-02-01 00:00:00
abstract：:Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:80:3:251
更新日期：2001-06-01 00:00:00
abstract：:Bioenvironmental trace elements play a vital role in plant, animal, and man metabolism. This study aims to determine trace element concentration in different parts (pods, pericarp, seeds, cotyledon, and taste) of the warm climate plant pigeon pea (Cajanus cajan L. Millsp.). The pigeon pea pods were collected from the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02256-y
更新日期：2020-06-20 00:00:00
abstract：:Auxiliary enzymes participate in β-oxidation of unsaturated fatty acids. The objective of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on Δ(3)Δ(2)-enoyl-CoA isomerase (ECI) in the liver and other tissues. Five groups of eight weanling rats each were fed...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9940-8
更新日期：2014-06-01 00:00:00
abstract：:Nickel (Ni) has not been elucidated as an essential mineral in dairy animals, though in plants and lower organisms, its role in activation of urease enzyme is well known. This study was conducted to evaluate the effect of Ni supplementation on intake, growth performance, urease activity, antioxidant and immune status,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1524-6
更新日期：2019-07-01 00:00:00
abstract：:Lack of specific markers constitutes a problem during diagnosis of headache syndromes. Recently, some metals have gained importance as biological parameters for the diagnosis and during treatment. Low-ionized Mg and high-ionized Ca/Mg in patients with daily migrainous headaches were noted. The blood Na level was shown...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1385/BTER:90:1-3:1
更新日期：2002-01-01 00:00:00
abstract：:Fluoride and lead are two common pollutants in the environment. Previous investigations have found that high fluoride exposure can increase the lead burden. In this experiment, in order to study on the molecular mechanisms of central neural system injury induced by the above two elements, differently expressed protein...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0117-2
更新日期：2014-12-01 00:00:00
abstract：:Analyzing the concentrations of heavy metals in the sera of umbilical cord blood samples can provide useful information about prenatal exposure to environmental agents. An analytical method based on ICP-MS to simultaneously determine multiple elements in umbilical cord blood samples was developed for assessing the in ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0853-6
更新日期：2017-05-01 00:00:00
abstract：:Arsenic is one of the most important environmental pollutants especially in drinking water. The S100B protein is presented as a sensitive biomarker for assessment of the blood-brain barrier integrity previously. The objective of this study was to determine the impact of chronic arsenic exposure in drinking water and s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1463-2
更新日期：2019-05-01 00:00:00
abstract：:The present study was designed to investigate the effect of mercuric chloride administration on copper, zinc, and iron concentrations in the liver, kidney, lung, heart, spleen, and muscle of rats. The results showed that after dose and time exposure to mercuric chloride, the concentration of mercury in the six tissues...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02910676
更新日期：1997-07-01 00:00:00
abstract：:An "anti-oxidant cocktail" consisting of betacarotene, vitamins B6, C, E, zinc, and selenium or corresponding placebos were given for one y as daily dietary supplements to 45 elderly residents of a nursing home. Initially, the serum TBA reactant levels were higher (2.7 +/- 0.7 mumol/L) than those of an ad hoc control ...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/BF02795458
更新日期：1988-09-01 00:00:00
abstract：:This study was focused on the analysis of arsenic (As) levels in scalp hair of children (age, <10 years) collected from two towns of Khairpur, Pakistan, to evaluate the effects of As-contaminated groundwater. For comparative purposes, scalp hair samples of children were also collected from that area having low levels ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8866-z
更新日期：2011-10-01 00:00:00
abstract：:This study was undertaken to evaluate a systematic analysis of mineral and trace elements of individual functionally determined parts of adult temporal bone. Marked differences were observed in basic structural elements (Ca, P, Mg, and Zn) among different bone regions. The more so, molar Ca/P ratio was significantly d...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF03032672
更新日期：1991-04-01 00:00:00
abstract：:In a controlled animal experiment the effects of dietary subacute Zn deficiency on growth, Zn concentration, and tissue 42-K distribution were studied. Growth retardation caused lower body weight because both skeletal and heart muscle showed a reduction in cell mass. Zn concentrations were reduced in most tissues, how...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789301
更新日期：1994-12-01 00:00:00
abstract：:The present study aimed to investigate the prevalence of thrombocytopenia and its association with serum magnesium in a nationally representative cohort. A total of 8478 participants aged 18 years and over were recruited in a cross-sectional survey. Thrombocytopenia was defined as platelet count less than 150 × 10(9)/...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0406-4
更新日期：2016-01-01 00:00:00
abstract：:The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood. In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9834-1
更新日期：2013-12-01 00:00:00
abstract：:Selenium is an essential nutrient in diets; however, the effects of selenium on enzyme metabolic activation are not currently clear. Cytochromes P450 (CYP450) are major phase I metabolic enzymes involved in the biotransformation of xenobiotics and endogenous compounds to form electrophilic reactive metabolites. To inv...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01945-7
更新日期：2020-08-01 00:00:00
abstract：:The aim of this study was to investigate the effects of the Toxoplasma gondii infection on the total content of the essential elements Zn and Mg levels. Plasma zinc and magnesium concentrations were measured in 158 patients whose anti-T gondii IgG antibodies were positive. Scores were obtained for the patients and the...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:92:1:11
更新日期：2003-04-01 00:00:00
abstract：:Using the dimethylbenz(a)anthracene-induced mammary tumor model in rats, our studies indicated that there was a dose-response relationship between dietary selenium supplementation and the inhibition of mammary carcinogenesis. The degree of inhibition was proportional to the level of dietary selenium up to 5 ppm, at wh...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02987217
更新日期：1983-08-01 00:00:00
abstract：:Three hundred and sixty healthy Ross × Ross 1-day-old broilers were used to study the effects of zinc glycine chelate (Zn-Gly) on oxidative stress, contents of trace elements, and intestinal morphology. All broilers were randomly assigned to six treatment groups, which replicates three times. Diets were as follows: (1...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8824-9
更新日期：2011-09-01 00:00:00
abstract：:The concentrations of 17 elements in the nail and hair of 117 subjects from a nonindustrialized environment were determined by instrumental neutron activation analysis (INAA). A new method of statistical treatment that allows for more meaningful use of detection limit values was used to process the concentration data....
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795450
更新日期：1988-09-01 00:00:00
abstract：:The trace elements antimony, bromine, cesium, cobalt, iron, rubidium, scandium, strontium and zinc were determined by instrumental neutron activation analysis in breast tissue samples with fibrocystic disease and in samples with fibroadenoma tumors. The histological lesions of each breast sample with fibrocystic disea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917337
更新日期：1994-10-01 00:00:00
abstract：:Copper is an essential trace element with various biological functions. Excess copper, however, is extremely toxic, leading to many pathological conditions that are consistent with oxidative damage to membranes and molecules. Exposure to high levels of copper results in various changes in the tissues. In liver, hypert...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:96:1-3:209
更新日期：2003-01-01 00:00:00
abstract：:The aim of the present study was to evaluate the oxidative stress level and antioxidant trace elements status associated with lower airway disease in draft horses. For this purpose, venous blood samples were obtained from draft horses exhibiting signs of lower respiratory tract disorders (n = 83) and from control grou...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9471-0
更新日期：2012-12-01 00:00:00
