Abstract：
:An "anti-oxidant cocktail" consisting of betacarotene, vitamins B6, C, E, zinc, and selenium or corresponding placebos were given for one y as daily dietary supplements to 45 elderly residents of a nursing home. Initially, the serum TBA reactant levels were higher (2.7 +/- 0.7 mumol/L) than those of an ad hoc control group of healthy younger adults (2.3 +/- 0.6 mumol/L), p less than 0.01. After three mo supplementation, the levels among the verum elderly had decreased to 2.2 +/- 0.6 mumol/L, and they remained at this lower level until the end of the study period, whereas the placebo group showed no change. A significant inverse correlation (r = -0.428, p less than 0.01) existed between the concentrations of serum TBA reactants and whole blood selenium (B-Se), but only B-Se levels above 200 micrograms/L were associated with a decrease in serum lipid peroxides. Serum alpha-tocopherol concentration also correlated inversely with serum TBA reactants but this correlation (r = -0.273, p less than 0.76) was not as strong as that of B-Se. Deficient vitamin B6 status, in biochemical terms, was observed in 25% of the elderly; a daily supplement of 2 mg B6 fully cured all cases of deficiency. The verum group improved slightly in several psychological tests, whereas subjects on placebo remained unchanged or deteriorated during the follow-up period. Clinical amelioration among the verum subjects was reported by the nurses; no toxic side effects were reported. In conclusion, the elderly benefited biochemically and clinically of dietary antioxidant supplements.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Tolonen M,Sarna S,Halme M,Tuominen SE,Westermarck T,Nordberg UR,Keinonen M,Schrijver Jdoi
10.1007/BF02795458subject
Has Abstractpub_date
1988-09-01 00:00:00pages
221-8eissn
0163-4984issn
1559-0720journal_volume
17pub_type
临床试验,杂志文章abstract：:A survey based on 838 samples of milk obtained from 537 dairies covering 70 of 95 districts in France was organized to assess iodine content of milk and its contribution to total intake. Iodine levels were significantly higher in winter than in summer. Very low iodine contents (less than 25 micrograms I/kg) were found...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784607
更新日期：1992-01-01 00:00:00
abstract：:The concentrations of various trace elements in amniotic fluid (AF) change over the course of pregnancy, with gestational age and fetus growth. The aim of the present study was to evaluate the concentrations of selected essential and toxic elements in AF and their relations to maternal and fetal parameters. The study ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0557-3
更新日期：2016-07-01 00:00:00
abstract：:Results from several medical investigations carried out using the Oxford scanning proton microprobe are presented, including maps of the hepatic copper-distribution in primary biliary cirrhosis and maps of the iron distribution in primary hemochromatosis. Preliminary studies of human nervous tissue reveal that morphol...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02796626
更新日期：1987-08-01 00:00:00
abstract：:Smoking is one of the major causes of mortality and numerous diseases, both directly and indirectly. The role of smoking as a significant risk factor is already known in several human diseases such as cardiovascular diseases, lung cancer, and chronic obstructive pulmonary disease. We aimed to compare the toxicity of h...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02537-6
更新日期：2021-01-20 00:00:00
abstract：:This review discusses the development of studies that evaluated the essentiality and requirements of iron from the ancient to the present. The therapeutic effects of iron compounds were recognized by the ancient Greeks and Romans. The earliest recognition of the essentiality of iron was stated by Paracelsus, a disting...
journal_title：Biological trace element research
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s12011-018-1584-7
更新日期：2019-03-01 00:00:00
abstract：:The present study was undertaken to investigate the utility of cystatin C (CysC) as an early biomarker of cadmium (Cd)-induced renal injury. The study was carried out on 50 adult male individuals divided into five groups of 10 individuals as follows: control, welders, smoker welders, diabetic welders, and smoker diabe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9939-1
更新日期：2014-06-01 00:00:00
abstract：:Because nickel may have a biological function in a pathway in which vitamin B12 is important, an experiment was performed to determine the effects of nitrous oxide exposure in rats deprived of nickel. Exposure to nitrous oxide (N2O) causes inactivation of cobalamin and a subsequent decrease in the vitamin B12-dependen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783980
更新日期：1993-07-01 00:00:00
abstract：:Nickel (Ni) has not been elucidated as an essential mineral in dairy animals, though in plants and lower organisms, its role in activation of urease enzyme is well known. This study was conducted to evaluate the effect of Ni supplementation on intake, growth performance, urease activity, antioxidant and immune status,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1524-6
更新日期：2019-07-01 00:00:00
abstract：:This study was focused on the analysis of arsenic (As) levels in scalp hair of children (age, <10 years) collected from two towns of Khairpur, Pakistan, to evaluate the effects of As-contaminated groundwater. For comparative purposes, scalp hair samples of children were also collected from that area having low levels ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8866-z
更新日期：2011-10-01 00:00:00
abstract：:The effect ofin utero zinc deficiency on fetal development in rats is reviewed. Attention is paid to the primary biochemical lesion associated with zinc-related teratogenesis and special consideration is given to the central nervous system. Evidence is presented that the thymidine kinase salvage pathway, used for the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916569
更新日期：1985-03-01 00:00:00
abstract：:Vanadium compounds maintain euglycemic effects in diabetic rats long after drug withdrawal and bis(α-furancarboxylato)oxovanadium(IV) (BFOV) possesses potent antidiabetic effects in diabetic rats. Here, we investigated the treatment and posttreatment effects of BFOV in diabetic Kuo Kondo [1, 2] with Ay gene (KKAy) mic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9689-5
更新日期：2013-06-01 00:00:00
abstract：:Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02402-6
更新日期：2020-10-06 00:00:00
abstract：:Although fish consumption has positive health effects, metals accumulated in fish can cause human health risks. In this study, the levels of ten metals in rainbow trout (Oncorhynchus mykiss) farmed in the Keban Dam Reservoir, which has the biggest rainbow trout production capacity in Turkey, were determined and compar...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1156-2
更新日期：2018-07-01 00:00:00
abstract：:The present study was designed to investigate the effects of montmorillonite (MMT) on dietary Cd-induced oxidative damage in liver and kidney of carp (Carassius auratus). One hundred eighty carp were randomly divided into four groups and fed with a basal diet, a basal diet supplemented with 0.5% MMT, Cd-comtaminated b...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8735-9
更新日期：2011-06-01 00:00:00
abstract：:Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association ...
journal_title：Biological trace element research
pub_type： 杂志文章,meta分析
doi：10.1007/s12011-017-0982-6
更新日期：2017-10-01 00:00:00
abstract：:Two experiments were conducted to study the performance, antioxidant activity, and bone mineral variables in broilers fed organic trace minerals (OTM) at lowered concentrations in the diet. In experiment 1, a total of 1500 day-old broiler male chicks were randomly distributed into six groups with 10 replicates of 25 c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02481-5
更新日期：2020-11-20 00:00:00
abstract：:In the present study, spectroscopic determinations of copper ions using chimeric metal-binding green fluorescent protein (His6GFP) as an active indicator have been explored. Supplementation of copper ions to the GFP solution led to a remarkable decrease of fluorescent intensity corresponding to metal concentrations. F...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8476-9
更新日期：2010-06-01 00:00:00
abstract：:This comparative study of the intestinal absorption of four toxic metals (aluminum, manganese, nickel, and lead) carried out in rats using the in situ intestinal perfusion technique was able to measure the partition of each metal between the intestine (intestinal retention), the blood circulation, and target tissues a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:99:1-3:157
更新日期：2004-07-01 00:00:00
abstract：:Many studies have shown that zinc deficiency could decrease the response to insulin. In genetically diabetic animals, a low zinc status has been observed contrary to induced diabetic animals. The zinc status of human patients depends on the type of diabetes and the age. Zinc supplementation seems to have beneficial ef...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02784615
更新日期：1992-01-01 00:00:00
abstract：:Although substantial progress has been achieved in inductovely coupled plasma (ICP) spectroscopy, placing it among the principal spectroscopic tools in analytical chemistry research and applications laboratories, some limitations exist especially for the analysis of ultratrace concentration levels in biological materi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02918324
更新日期：1984-02-01 00:00:00
abstract：:The present study aimed to investigate the prevalence of thrombocytopenia and its association with serum magnesium in a nationally representative cohort. A total of 8478 participants aged 18 years and over were recruited in a cross-sectional survey. Thrombocytopenia was defined as platelet count less than 150 × 10(9)/...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0406-4
更新日期：2016-01-01 00:00:00
abstract：:The key role of osteoblasts in skeletal fluorosis makes the exploration of the possible mechanisms of the fluoride-induced oxidative stress of osteoblasts of great importance. In this article, the in vitro effects of fluoride on the oxidative stress of osteoblasts are presented. To study the inhibitory effect of baica...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02685921
更新日期：2007-04-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF03032684
更新日期：1991-06-01 00:00:00
abstract：:Obesity is a major public health problem worldwide and a risk factor for certain diseases, including cardiovascular disease, diabetes, cancer, and depression. Unfortunately, currently available anti-obesity drugs have failed in the long-term maintenance of weight control. It has been a challenge to design novel drugs ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01738-y
更新日期：2020-02-01 00:00:00
abstract：:The study was conducted to evaluate the effects of chromium-loaded chitosan nanoparticles (Cr-CNP) on glucose transporter 4 (GLUT4), relevant messenger RNA (mRNA), and proteins involved in phosphatidylinositol 3-kinase (PI3K), Akt2-kinase, and AMP-activated protein kinase (AMPK) of skeletal muscles in finishing pigs. ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0890-1
更新日期：2017-07-01 00:00:00
abstract：:Trace element contamination in Chinese herbal medicines has been recognized as a potential health concern for consumers. To assess the health risk to the herb-consuming population, nine trace elements (Cu, Cd, Cr, Mo, Ni, Pb, Sr, Zn, and As) were investigated based on their concentrations in three common medicinal pla...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02539-4
更新日期：2021-01-03 00:00:00
abstract：:Lead is a biohazardous metal that is commonly involved in human illness including renal injury. Although it is a non-redox reactive metal, lead-induced renal injury is largely based on oxidative stress. The current work aimed at exploring the possible protective effect of γ-glutamyl cysteine (γGC) against lead-induced...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0624-4
更新日期：2016-09-01 00:00:00
abstract：:Three kinds of plant leaves, Chinese white aspen, arborvitae, and pine needles, have been sampled from the Yanshan Oil refinery complex, the Capital Iron and Steel Factory, and Badachu, a control area in Beijing, as biomonitors for air-pollution studies. Each sample was divided into two parts, washed, and unwashed. Th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784212
更新日期：1999-01-01 00:00:00
abstract：:Inducing the differentiation of stem cells from human exfoliated deciduous teeth (SHEDs) proceeds with low efficiency, which greatly limits clinical applications. Divalent metal elements play an important role in osteoinductivity for bone remodeling because they can simulate bone formation and decrease bone resorption...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1256-7
更新日期：2018-10-01 00:00:00
abstract：:Concentration of heavy metals (lead (Pb), cadmium (Cd), chromium (Cr), and copper (Cu)) was determined in the liver, gills, kidneys, and muscles of eight edible fish species (Channa punctata, Cirrhinus reba, Labeo rohita, Heteropneustes fossilis, Mystus cavasius, Oreochromis niloticus, Puntius sophore, and Wallago att...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9011-3
更新日期：2011-12-01 00:00:00
