Abstract:
:Obesity is a major public health problem worldwide and a risk factor for certain diseases, including cardiovascular disease, diabetes, cancer, and depression. Unfortunately, currently available anti-obesity drugs have failed in the long-term maintenance of weight control. It has been a challenge to design novel drugs that could potentially treat obesity or prevent uncontrolled weight-gain which lies underneath the pathology of obesity. Since obesity in a way is a consequence of the accumulating new mature adipocytes from undifferentiated precursors which is a process also termed as adipogenesis, drugs that might control adipogenesis could be beneficial for the treatment of obesity. In the current study, combined effect of sodium pentaborate pentahydrate (NaB) and pluronic F68 on adipogenic differentiation was examined by administering various combinations of the two agents to human adipose-derived stem cells (hADSCs) in in vitro. Immunocytochemistry and quantitative RT-PCR were performed to evaluate the levels of adipogenesis-promoting genes such as peroxisome proliferator-activated receptor-γ (PPARγ), fatty acid binding protein (FABP4), and adiponectin. Results indicated that expressions of all these three genes were restrained. Furthermore, Oil Red O staining revealed that lipid vesicle formation was reduced in hADSCs treated with differentiation medium containing NaB/F68 combination. Finally, expression levels of Hippo pathway kinases Lats2, MST1, and scaffold protein Sav1 were reduced in these cells, suggesting a possible link between Hippo pathway-dependent downregulation of PPARγ and the NaB/F68 treatment. Herein, we showed that combination of NaB and F68 curtails adipocyte differentiation by inhibiting the adipogenic transcriptional program leading to a decrease in lipid accumulation in adipocytes even at very low doses, thereby uncovered a striking opportunity to use this combination in obesity treatment.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Yilmaz AB,Tapsin S,Elbasan EB,Kayhan HD,Sahin F,Turkel Ndoi
10.1007/s12011-019-01738-ysubject
Has Abstractpub_date
2020-02-01 00:00:00pages
390-399issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-019-01738-yjournal_volume
193pub_type
杂志文章abstract::Type 2 diabetes is characterized by hyperglycemia and oxidative stress. Hyperglycemia is linked to mitochondrial dysfunction and reduced β-cell mass due to the reduced expression of genes such as Mfn2 as well as the participation of the Bcl2 gene family, responsible for increased apoptosis. The purpose of this study w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9666-z
更新日期:2013-06-01 00:00:00
abstract::The aim of present study was to compare the level of manganese (Mn) with thyroid functions, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxin (FT4) of females having hyper- (HPRT) and hypothyroid (HPOT) disorder. For comparative study, females of the same age group (16-30 years) having ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0277-8
更新日期:2015-10-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8357-2
更新日期:2009-11-01 00:00:00
abstract::The objective of this paper is to investigate the correlation between serum macro-element and trace element contents and bone mineral density (BMD) as well as the occurrence of osteoporosis. After the epidemiological investigation of 290 postmenopausal women from ages 45 to 65 in the Xi'an urban area, their blood was ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8363-4
更新日期:2009-12-01 00:00:00
abstract::Naphthalene-1-acetic acid (HNAA), dichlorophenoxy acetic acid (HDAA), and indole-3-acetic acid (HIAA) are auxinhormones that can affect the growth of plants. The lanthanide complexes of the above auxinhormone LnA3 x 3H2O (Ln = La3+, Ce3+, Sm3+, Er3+, Yb3+; HA = HNAA, HDAA, HIAA; A = NAA-, DAA-, IAA-) were synthesized ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783322
更新日期:1998-07-01 00:00:00
abstract::The objective of the present study was to evaluate the potential effect of maternal cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Between November 2002 and December 2003, 109 normal pregnant women were enrolled in our cohort from Da-Ye Country, Hubei Province in Central China...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8391-0
更新日期:2009-12-01 00:00:00
abstract::Yerba mate (Ilex paraguariensis), a widely consumed beverage in South America, contains various biochemically active substances, among them are several minerals. This paper reports on the results of a survey of trace elements in the yerba mate infusions. Three different commercially available trademarks of I. paraguar...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9056-3
更新日期:2011-12-01 00:00:00
abstract::Fruit juices are widely consumed in tropical countries as part of habitual diet. The concentrations of several minerals in these beverages were evaluated. Four commercially available brands of juices were analyzed for cadmium, lead, copper, zinc, aluminum, iron, chromium, manganese, and molybdenum. The levels ranged f...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9247-y
更新日期:2012-05-01 00:00:00
abstract::Quantitative analysis of follicular fluid and granulosa cells from small, medium and large antral atretic follicles of goat (Capra hircus) ovaries was conducted to study the alterations in trace elements viz zinc (Zn), copper (Cu), manganese (Mn), and iron (Fe). The zinc content was lower in the follicular fluid (0.99...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8700-7
更新日期:2011-06-01 00:00:00
abstract::Zinc uptake regulator (Zur) is a negative transcriptional regulator of bacteria that belongs to the FUR superfamily of proteins and regulates zinc (Zn) homeostasis under extreme Zn conditions. The Zur protein of Bacillus anthracis (BaZur) was though characterized previously, but the residues of this transcriptional re...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02427-x
更新日期:2020-10-14 00:00:00
abstract::The authors present a simple and rapid method for assaying ultrafilterable copper (Cu UF) and albumin-bound copper (Cu ALB). It is based on the ultrafiltration of serum in the presence of ethylenediaminetetraacetic acid (EDTA), used to prevent adsorption on the membranes. EDTA at 0.4 g/L has no effect on the equilibri...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917499
更新日期:1988-12-01 00:00:00
abstract::Several authors have already underlined chromium implication in glucose and lipids metabolism of humans. In this field, physiological chromium determination in serum could be helpful, but the discrepancies reported in numerous papers are confusing. Here we report some results obtained by Zeeman correction Graphite Fur...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784591
更新日期:1992-01-01 00:00:00
abstract::Aluminum (Al) exposure inhibits bone formation. Osteoblastic proliferation promotes bone formation. Therefore, we inferred that Al may inhibit bone formation by the inhibition of osteoblastic proliferation. However, the effects and molecular mechanisms of Al on osteoblastic proliferation are still under investigation....
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0880-3
更新日期:2017-06-01 00:00:00
abstract::In this experimental study, the effect of cadmium on cold and restraint stress-induced gastric lesions has been studied. Rats received 15 micrograms/mL cadmium-containing water for 30 d, and at the end of this period, they were subjected to cold and restraint stress. Cadmium accumulation in gastric mucosa was associat...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790120
更新日期:1995-01-01 00:00:00
abstract::Plasma molybdenum concentrations were determined in children, ages two to 12 yr, with and without phenylketonuria (PKU). Mean plasma molybdenum concentrations did not differ significantly between the children with PKU (1.33 +/- 0.5 microgram/L) and without PKU (1.75 +/- 0.8 microgram/L). Plasma molybdenum concentratio...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785307
更新日期:1993-09-01 00:00:00
abstract::The efficacy of selenate and other divalent anions to stimulate the efflux of radiolabeled sulfate from lactating rat mammary tissue slices has been examined. Both selenate and sulfate markedly increased the fractional release of sulfate via a system that is temperature-sensitive and sensitive to the anion-exchange in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917205
更新日期:1990-03-01 00:00:00
abstract::Selenoprotein K (SelK), a member of selenoprotein family, is identified as a single endoplasmic reticulum (ER) transmembrane protein. Although over-expression of SelK inhibits adherence and migration of human gastric cancer BGC-823 cells, the effects of SelK in human choriocarcinoma (CCA) are not well understood. In t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1155-3
更新日期:2018-07-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of multifactorial origin. Studies have shown that trace elements such as zinc and copper may help maintain optimum function of the immune system and metabolism, while toxic metals such as lead may increase systemic autoimmunity. The curren...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-018-1592-7
更新日期:2019-09-01 00:00:00
abstract::Cerium has been implicated in the pathogenesis of cardiac disorders such as acute myocardial infarction and endomyocardial fibrosis (EMF). A geochemical hypothesis for the causation of EMF linked the cardiac lesions to magnesium deficiency consequent to malnutrition and increased cardiac levels of cerium derived from ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:114:1:85
更新日期:2006-01-01 00:00:00
abstract::This study was focused on the analysis of arsenic (As) levels in scalp hair of children (age, <10 years) collected from two towns of Khairpur, Pakistan, to evaluate the effects of As-contaminated groundwater. For comparative purposes, scalp hair samples of children were also collected from that area having low levels ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8866-z
更新日期:2011-10-01 00:00:00
abstract::Numerous observations suggest a possible connection between the levels of Mg, Zn, Fe, and Zn and the incidence of depressive symptoms. Depression is two to three times more common in women than in men. The menopausal period is extremely conducive to depressive disorders. The aim of this study was to assess the severit...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0798-9
更新日期:2017-03-01 00:00:00
abstract::Interaction of elements in the course of element uptake by carrot (Daucas carota cv. U.S. harumakigosun) exerted by the addition of elements, such as Rb, Zn, and Al, was investigated. For the purpose of precise evaluation of uptake behavior, the simultaneous determination of absorption of Na, Be, Sr, Mn, Co, Zn, Ce, P...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:84:1-3:197
更新日期:2001-01-01 00:00:00
abstract::Various studies indicate the role of manganese (Mn) in the virulence of pathogens. Salmonella is an intracellular pathogen which is able to multiply within the macrophages. The present study was therefore, designed to assess the effect of Mn supplementation on Salmonella-macrophage interactions particularly in referen...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8406-x
更新日期:2010-01-01 00:00:00
abstract::Women with preeclampsia have been shown to have elevated blood levels of the metabolite homocysteine, and alterations in blood levels of zinc and copper have also been reported. This study measured plasma levels of zinc, copper, and homocysteine in women with preeclampsia and in women with healthy, normotensive pregna...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:104:2:097
更新日期:2005-05-01 00:00:00
abstract::Copper is an essential trace element with various biological functions. Excess copper, however, is extremely toxic, leading to many pathological conditions that are consistent with oxidative damage to membranes and molecules. Exposure to high levels of copper results in various changes in the tissues. In liver, hypert...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:96:1-3:209
更新日期:2003-01-01 00:00:00
abstract::Assessment of trace element levels in general population from the specific area is of importance for nutritional and occupational monitoring. In the current study, baseline blood levels of 12 toxic and/or essential metals and metalloids, including arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), chromium (Cr), tha...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1486-8
更新日期:2019-06-01 00:00:00
abstract::The degree of chromosome damage induced by three compounds of zinc (zinc chloride, zinc sulfate, zinc acetate) was compared in human leucocytes in vitro. Three concentrations of each salt, 3.0 x 10(-5)M, 3.0 x 10(-4)M, and 1.5 x 10(-3)M, were added to leukocyte cultures. The cells were harvested after 48 and 72 h and ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:78:1-3:113
更新日期:2000-01-01 00:00:00
abstract::In zinc deficiency, the function of leukocytes is impaired. However, the results of studies on the zinc concentration of blood cells in zinc deficiency are conflicting, probably in part because of technical and analytical problems. The aim of this study was to investigate, under standard conditions, the uptake of 65Zn...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783726
更新日期:1992-11-01 00:00:00
abstract::Cadmium (Cd) pollution and acid rain are the main environmental issues, and they often occur in the same agricultural region. Nevertheless, up to now, little information on the combined pollution of Cd(2+) and acid rain action on crops were presented. Here, we investigated the combined effect of Cd(2+) and acid rain o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9053-6
更新日期:2011-12-01 00:00:00
abstract::Calcium, magnesium, and zinc balances were determined in eleven young adult college females (mean age, 24.9±2.35) during a 39-d metabolic study when the subjects were fed an adequate calorie and protein diet based on habitually consumed foods. Analysis showed that the dietary contribution of calcium, magnesium, and zi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917454
更新日期:1985-11-01 00:00:00