Abstract：
:Type 2 diabetes is characterized by hyperglycemia and oxidative stress. Hyperglycemia is linked to mitochondrial dysfunction and reduced β-cell mass due to the reduced expression of genes such as Mfn2 as well as the participation of the Bcl2 gene family, responsible for increased apoptosis. The purpose of this study was to describe the effect of different iron and/or glucose concentrations over Mfn2, Bax, and Bcl2 expressions in a β-pancreatic cell line (MIN6 cells). MIN6 cells were pre-incubated with different iron and/or glucose concentrations, and the relative mRNA abundance of the Bcl2/Bax ratio and of Mfn2 genes was measured by qRT-PCR. Heme oxygenase (HO) activity, iron uptake, superoxide dismutase activity, and glutathione content were also determined. The Bcl2/Bax ratio increased and Mfn2 expression decreased in MIN6 cells after glucose stimulation. These effects were higher when glucose and iron were incubated together. Additionally, treatment with glucose/iron showed a higher HO activity. Our study revealed that high glucose/Fe concentrations in MIN6 cells induced an increase of the Bcl2/Bax ratio, an indicator of increased cell apoptosis.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Fuentes M,Andrews M,Arredondo-Olguín Mdoi
10.1007/s12011-013-9666-zsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
390-5issue
1-3eissn
0163-4984issn
1559-0720journal_volume
153pub_type
杂志文章abstract：:The decline in fish population because of water contamination is problem. As a result of direct exposure in water, it has been readily accepted that the gills are the main site of water contamination and toxicity (e.g., metal ions). In the present study, we investigated metal ion contamination on the functional capaci...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:100:3:229
更新日期：2004-09-01 00:00:00
abstract：:A simple, quick procedure has been developed for preparation of human lenses for total chromium (Cr) analysis by electrothermal atomic absorption spectrometry (EAAS). This procedure involves wet ashing in a mini-autoclave with HNO3 and H2SO4. Recovery was 101.6%. This procedure is simple to carry out, does not generat...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784598
更新日期：1992-01-01 00:00:00
abstract：:Zinc (Zn) is essential for development, growth, and reproduction. The Mexican government subsidizes micronutrient-fortified milk for risk groups, with positive effect on the targeted groups' plasma Zn level, inferring a good absorption is achieved although it has not being measured. The aim of this study was to determ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0356-x
更新日期：2015-11-01 00:00:00
abstract：:There have been few investigations of trace elements in the urine and hair of populations exposed to high levels of arsenic (As) in drinking water. Therefore, concentrations of selected metals in urine and hair samples from a population in a study area where arsenism was endemic and a control area were determined. It ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1108-x
更新日期：2018-04-01 00:00:00
abstract：:The present work aimed at assessing passive, innate, and acquired immunity in piglets from sows supplemented with either organic or inorganic selenium (Se). A total of 12 multiparous pregnant sows were randomly allocated to three groups: selenium-deficient, corn and soy-based diet base diet (BD), 0.3 mg Se/kg as hydro...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01754-y
更新日期：2020-03-01 00:00:00
abstract：:The aim of this study was to evaluate and compare the oxidative profiles of three thyroid disorders: Graves' disease (GD), Hashimoto thyroiditis (HT), and papillary thyroid cancer (PTC). Malondialdehyde levels (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities were examined ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8625-1
更新日期：2010-12-01 00:00:00
abstract：:The aim of this study was to investigate the relationships between the bronchopneumonia and mean concentrations of those trace elements in bronchoalveolar lavage fluid (BALF). Twenty-nine dogs were included this study (17 healthy dogs and 12 dogs with respiratory disease). Each BALF sample had been obtained during bro...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8149-0
更新日期：2008-07-01 00:00:00
abstract：:The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 6 per group). Each group received 1 mL (intragastrically) of...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0293-8
更新日期：2015-09-01 00:00:00
abstract：:Fluoride (F) concentration in blood serum of healthy dromedary camel population was measured, and its relationship with age and sex was determined. In male animals, the level varied from 0.017 to 0.296 ppm, with mean (± S.E.) value of 0.163 ± 0.013 ppm. In females, the level varied from 0.036 to 0.372 ppm with mean va...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02534-9
更新日期：2021-01-06 00:00:00
abstract：:The selenium levels and the glutathione peroxidase activity GSH-PX of whole blood and of erythrocytes, respectively, were determined in 139 normal Danes and related to sex and smoking habits. No differences were found in relation to sex apart from a higher GSH-PX activity of females when assayed with tertiary butyl hy...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/BF02990131
更新日期：1988-01-01 00:00:00
abstract：:In three fully crossed, factorially arranged, completely randomized experiments, female weanling rats were fed a basal diet (containing about 10 ng of nickel and 2.3 μg of iron/g) supplemented with graded levels of nickel and iron. Iron was supplemented to the diet in experiment 1 at levels of 0, 25, 50, and 100 μg/g ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990121
更新日期：1981-09-01 00:00:00
abstract：:Three kinds of plant leaves, Chinese white aspen, arborvitae, and pine needles, have been sampled from the Yanshan Oil refinery complex, the Capital Iron and Steel Factory, and Badachu, a control area in Beijing, as biomonitors for air-pollution studies. Each sample was divided into two parts, washed, and unwashed. Th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784212
更新日期：1999-01-01 00:00:00
abstract：:Selenium was added to the feed of White Leghorn type chickens 1 day prior to challenge with either Escherichia coli or sheep erythrocyte antigen. The incidence of death or lesions was reduced from 86% to 21% at the optimal dose of selenium (0.4 mg/kg resulting in feed concentration of 0.45 mg/kg). After the chickens w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917469
更新日期：1997-09-01 00:00:00
abstract：:Our previous studies showed that serum calcium level may have influence in the blood pressure to older male subjects, but the relationship between serum calcium level and blood lipids is unclear. The aim of this study was to evaluate the relationship between total serum calcium level and blood lipids. In our study, to...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9895-9
更新日期：2014-03-01 00:00:00
abstract：:Zinc absorption from the alimentary tract, as revealed by serum zinc concentration, was studied in a group of 10 patients (age 37.7+/-5.1 yr) with moderate and severe untreated primary arterial hypertension before and after a 30-d treatment with perindopril 4 mg/d. Blood pressure was 177.33+/-16.24/111.33+/-15.26 mm H...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:83:1:31
更新日期：2001-10-01 00:00:00
abstract：:Suppression subtractive hybridization analysis in our laboratory recently revealed that transferrin mRNA may be elevated in Sedeficient rat liver. In this work, we compared expression in rat liver of genes for transferrin, transferrin receptor, ferritin light and heavy chains, and iron-regulatory proteins 1 and 2 in S...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:74:1:55
更新日期：2000-04-01 00:00:00
abstract：:Information on cadmium (Cd) uptake and transport is essential to understand better the physiology of Cd tolerance in plants. In this study, Cd uptake, translocation, and tolerance were investigated in AHA1 (Arabidopsis plasma membrane H(+)-ATPase gene) overexpressed plants. Exposed to 10 µM CdCl(2), AHA1OX showed a hi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8657-6
更新日期：2011-02-01 00:00:00
abstract：:Two experiments were conducted to study the performance, antioxidant activity, and bone mineral variables in broilers fed organic trace minerals (OTM) at lowered concentrations in the diet. In experiment 1, a total of 1500 day-old broiler male chicks were randomly distributed into six groups with 10 replicates of 25 c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02481-5
更新日期：2020-11-20 00:00:00
abstract：:Cadmium (Cd) pollution and acid rain are the main environmental issues, and they often occur in the same agricultural region. Nevertheless, up to now, little information on the combined pollution of Cd(2+) and acid rain action on crops were presented. Here, we investigated the combined effect of Cd(2+) and acid rain o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9053-6
更新日期：2011-12-01 00:00:00
abstract：:The contribution of gamma-ray scattering to the total efficiency for point-source geometries in a gamma spectrometer was measured. Scattering of gamma-rays on the shield and in the sample was considered. For a 25% efficiency detector in a small shield, about a 1% contribution to the total efficiency was measured, wher...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917374
更新日期：1994-10-01 00:00:00
abstract：:The aim of this study was to establish the possible effects of the sampling protocol (between-breast, within-feed, and diurnal differences) and the mother's personal factors (age, parity, iron supplementation, smoking habits, and lactation period) on the copper, iron, and zinc contents in human milk. One hundred thirt...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:76:3:217
更新日期：2000-09-01 00:00:00
abstract：:Studies were designed to characterize the plasma membrane polypeptide composition of normal rat kidney (NRK) and virus-transformed NRK cells as a function of time following iron deprivation. Using this approach we found that rapid depletion of iron from the cells increases the amounts of two membrane-associated glycop...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02821711
更新日期：1979-06-01 00:00:00
abstract：:Scleroderma, sclerosis of the skin, is a severe autoimmune disease refractant to all kind of treatments. To study the in vivo effects of a combination of three oligoelements selenium (Se), zinc (Zn), and manganese (Mn) plus Lachesis muta venom (O-LM) on the bleomycin (BLM)-induced scleroderma mouse experimental model....
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9876-4
更新日期：2014-02-01 00:00:00
abstract：:Previous studies have shown that there is a controversial relationship between iron homeostasis and obesity. This study aims to explore the relationship of anemia and iron status with different body size phenotypes in adult Chinese population. Using information on iron status-related parameters and lifestyle data from...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1213-x
更新日期：2018-09-01 00:00:00
abstract：:The molecular localization of maternal and fetal zinc and copper metalloproteins in diabetic and control rats was studied. Compared to controls, liver and kidneys of diabetic dams showed an increased concentration of zinc and copper that was associated with metallothionein. In contrast, fetuses of diabetic dams had lo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917490
更新日期：1988-12-01 00:00:00
abstract：:The liver of Hooded Seal (Cystophora cristata) consists of six lobes of unequal sizes. Extensive sampling by means of cutout samples covering the depth horizon 2-30 mm below liver surface indicates that the liver may be considered homogeneous as to concentrations of zinc, cadmium, mercury, and selenium (residuals of o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789141
更新日期：1990-01-01 00:00:00
abstract：:Preoperative diagnosis of papillary thyroid carcinoma (PTC) comprises numerous diagnostic procedures which are mostly applicable in tertiary institutions. Normal thyroid function depends on the presence of many trace elements and copper (Cu) and zinc (Zn) are some of those. The study is based on retrospective review o...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-014-0071-z
更新日期：2014-09-01 00:00:00
abstract：:The present study investigated the role of kisspeptin-10 on reproductively significant trace elements in relation to testosterone release in male rabbits, Oryctolagus cuniculus. Groups of rabbits were exposed to single 1 μg kisspeptin dose (i.v., saphenous vein), while simultaneous groups were pretreated with a kisspe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9720-x
更新日期：2013-08-01 00:00:00
abstract：:Mitochondria from Trigonella foenum-graecum seedlings grown independently in the presence of either selenium (0.75 ppm) or mimosine (0.1 mM) exhibited respiration-stimulated energy-dependent uptake of Ca2+. Uptake studies were carried out independently at a series of Ca2+ concentrations at two different levels: (1) 1-...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:82:1-3:217
更新日期：2001-07-01 00:00:00
abstract：:Because nickel may have a biological function in a pathway in which vitamin B12 is important, an experiment was performed to determine the effects of nitrous oxide exposure in rats deprived of nickel. Exposure to nitrous oxide (N2O) causes inactivation of cobalamin and a subsequent decrease in the vitamin B12-dependen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783980
更新日期：1993-07-01 00:00:00
