Abstract:
:The authors present a simple and rapid method for assaying ultrafilterable copper (Cu UF) and albumin-bound copper (Cu ALB). It is based on the ultrafiltration of serum in the presence of ethylenediaminetetraacetic acid (EDTA), used to prevent adsorption on the membranes. EDTA at 0.4 g/L has no effect on the equilibrium of serum copper vectors and enables Cu UF to be assayed by flameless atomic absorption. EDTA at 2 g/L is used to assay total exchangeable copper (CU EXC) (ultrafilterable + albumin-bound). The evaluation criteria of the method are furnished, as are the normal values in healthy subjects: 14.6 micrograms/L for Cu UF and 87 micrograms/L for Cu EXC. Finally, the usefulness of the methods described here for the diagnosis of Wilson's and Menkes' disease was demonstrated.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Favier A,Ruffieux Ddoi
10.1007/BF02917499subject
Has Abstractpub_date
1988-12-01 00:00:00pages
145-60eissn
0163-4984issn
1559-0720journal_volume
18pub_type
杂志文章abstract::The trace element selenium is an essential micronutrient for human health and its low levels in serum are implicated in the pathogenesis of several chronic diseases. Therefore, the determination of total selenium in serum may contribute to the assessment of the health and nutritional status of certain populations. The...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8252-2
更新日期:2009-04-01 00:00:00
abstract::Two trials were conducted in a 2 × 2 + 1 factorial arrangement based on a completely randomized design to evaluate the effects of different sources of selenium (Se) on performance, blood metabolites, and nutrient digestibility in male lambs on a barley-based diet. The first trial lasted for 70 days and consisted of 30...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9698-4
更新日期:2013-07-01 00:00:00
abstract::Cadmium concentrations were determined in the hair of 226 school children in an industrial and in a rural area of Tarragona Province (NE Spain). The influence of sex, age, hair color, smoking habits of the household members, and parents' occupation on the children's hair cadmium levels was also evaluated. Children liv...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02863080
更新日期:1991-02-01 00:00:00
abstract::To examine whether an accumulation of Ca in the tissues was accompanied by an increase of Mg, the authors investigated the relationships between Ca and Mg contents in the common iliac arteries, aortic valves, xiphoid processes, costal cartilages, posterior longitudinal ligaments, trigeminal nerves, and ribs by inducti...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:102:1-3:083
更新日期:2004-01-01 00:00:00
abstract::Cerium has been implicated in the pathogenesis of cardiac disorders such as acute myocardial infarction and endomyocardial fibrosis (EMF). A geochemical hypothesis for the causation of EMF linked the cardiac lesions to magnesium deficiency consequent to malnutrition and increased cardiac levels of cerium derived from ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:114:1:85
更新日期:2006-01-01 00:00:00
abstract::Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable Cu application. Cu-Z...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-0965-7
更新日期:2017-10-01 00:00:00
abstract::The purpose of this study was to determine glutathione peroxidase (GSHPx) activity in the liver of red deer in relation to selenium concentrations in the liver, as well as to evaluate changes in GSHPx activity according to sex, body weight and season of the year. Total selenium concentration in the liver of red deer a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9022-0
更新日期:2011-12-01 00:00:00
abstract::To elucidate compositional changes of the mitral valve with aging, the authors investigated the relationships among element contents in the mitral valves. The subjects consisted of 10 men and 15 women, ranging in age from 65 to 102 yr. After the ordinary dissection, mitral valves, lower parts of the interventricular s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:88:3:203
更新日期:2002-09-01 00:00:00
abstract::Plasma molybdenum concentrations were determined in children, ages two to 12 yr, with and without phenylketonuria (PKU). Mean plasma molybdenum concentrations did not differ significantly between the children with PKU (1.33 +/- 0.5 microgram/L) and without PKU (1.75 +/- 0.8 microgram/L). Plasma molybdenum concentratio...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785307
更新日期:1993-09-01 00:00:00
abstract::Pituitary dwarfism (hGHD) is known to be associated with trace element deficiency, which causes improper functioning of the involved endocrine system. Previously, we reported on the head hair concentrations of zinc, copper, manganese, and iron from a total of 418 normal subjects (154 male and 264 female). In this repo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:85:2:127
更新日期:2002-02-01 00:00:00
abstract::The effect of ad libitum ingestion of selenium (Se) in drinking water (0.15 mg SeO2/L) for 3 wk on the brain weight, total brain protein, glutathione (GSH) level, catalase activity, and lipid peroxidation in the brain of protein-undernourished (PU) rats was investigated, in an attempt to determine whether antioxidants...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02685933
更新日期:2007-05-01 00:00:00
abstract::Some studies have found that nano-sized titanium dioxide (nano-TiO2) has adverse effects on the male reproductive system. Blood-testis barrier (BTB), as one of the tightest blood-tissue restriction, is crucial to the male reproductive system. However, the potential effects on BTB and signaling pathway changes in testi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02404-4
更新日期:2020-09-29 00:00:00
abstract::Strontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a bone-seeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9158-y
更新日期:2012-01-01 00:00:00
abstract::The forms of Se in the Se-dependent enzyme formate dehydrogenase is known to be selenocysteine, but the way this amino acid enters the polypeptide chain has not been established. Through the use of a cysteine-requiring mutant ofEscherichia coli K-12 that could also grow in the presence of glutathione, we were able to ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795520
更新日期:1986-12-01 00:00:00
abstract::In this experimental study, the effect of cadmium on cold and restraint stress-induced gastric lesions has been studied. Rats received 15 micrograms/mL cadmium-containing water for 30 d, and at the end of this period, they were subjected to cold and restraint stress. Cadmium accumulation in gastric mucosa was associat...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790120
更新日期:1995-01-01 00:00:00
abstract::Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric disturbances and may arise from an impaired or not fully developed excretion system, transporter malfunction and/or exposure to excessive levels of Mn. Therefore, dec...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1531-7
更新日期:2019-03-01 00:00:00
abstract::This study was undertaken to evaluate a systematic analysis of mineral and trace elements of individual functionally determined parts of adult temporal bone. Marked differences were observed in basic structural elements (Ca, P, Mg, and Zn) among different bone regions. The more so, molar Ca/P ratio was significantly d...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF03032672
更新日期:1991-04-01 00:00:00
abstract::Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) bas...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9325-9
更新日期:2012-06-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of multifactorial origin. Studies have shown that trace elements such as zinc and copper may help maintain optimum function of the immune system and metabolism, while toxic metals such as lead may increase systemic autoimmunity. The curren...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-018-1592-7
更新日期:2019-09-01 00:00:00
abstract::Arsenite has been known for half a century to have a protective effect against selenium poisoning. Paradoxically, arsenite inhibits the conversion of inorganic selenium salts to methylated excretory products, although methylation has long been regarded as a detoxification mechanism for selenium. Moreover, there is evi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02919103
更新日期:1989-04-01 00:00:00
abstract::A double label procedure with 57Co and 58Co has been developed for detailed in vivo studies of erythrocyte survival. A well-type Ge detector is used in the measurements. The activities necessary for these experiments are very low, and the associated dose received by the test persons can be neglected. ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992664
更新日期:1990-07-01 00:00:00
abstract::Two 42-d experiments were conducted with weanling male rats to study interactions between nickel and copper. In Experiment 1, a low-copper basal diet was supplemented with copper at 0 or 30 ppm and nickel at 0 or 30 ppm. Copper was added in Experiment 2 to a basal copper-deficient diet at a level of 0 or 15 ppm and ni...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916540
更新日期:1985-04-01 00:00:00
abstract::Selenium-containing proteins in human serum of four volunteers in Beijing were separated and purified by preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Selenium contents in the proteins were quantified by high-performance liquid chromatography (HPLC) coupled with a fluorescence detec...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:100:2:105
更新日期:2004-08-01 00:00:00
abstract::Nowadays, 70 % of global monogastric feeds contains an exogenous phytase. Phytase supplementation has enabled a more efficient utilisation of phytate phosphorous (P) and reduction of P pollution. Trace minerals, such as iron (Fe), zinc (Zn), copper (Cu) and manganese (Mn) are essential for maintaining health and immun...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0161-y
更新日期:2015-02-01 00:00:00
abstract::This study aimed to determine the effect of excessive fluoride (F) on the morphological characteristics of the small intestine and the contents of serum cytokines in rats. A total of 48 3-week-old healthy female Sprague-Dawley rats were randomly divided into four groups (n = 12). The control group was given deionized ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1503-y
更新日期:2019-06-01 00:00:00
abstract::Male Sprague-Dawley rats, weighing 175-200 g, six per group were fed AIN 93M diet (CON) or diets containing 500 mg Ca (LCa), 7 mg Zn (LZn), 2 mg Cu (LCu), 60 mg Zn (HZn), or 12 mg Cu (HCu) per kilogram of diet in the following combinations: control (CON), LCa+LZn (LC+Z), LCa+LZn+LCu (LC+Z+C), or HZn+HCu (HZ+C) without...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:108:1-3:169
更新日期:2005-01-01 00:00:00
abstract::Woodlice are top consumers of a three-trophic system (soil, leaf litter, woodlice), and they are closely related to pollutant absorbing surfaces such as soil, leaf litter, and organic matter. We studied the effects of urbanization on trace element concentrations and fluctuating asymmetry of Armadillidium vulgare (Crus...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1454-3
更新日期:2019-05-01 00:00:00
abstract::In the current study, 48 male rats were classified into four groups (12 rats/group): 1-control group received 1 ml distilled water, 2-origanum oil group treated daily with oral dose of origanum oil (5 mg/kg) for 30 and 60 days, 3-mercuric chloride group treated daily with oral dose of mercuric chloride (4 mg/kg) for 3...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1067-2
更新日期:2018-03-01 00:00:00
abstract::The interaction of the vanadyl (IV) cation with N-acetyl-D-galactosamine, D-galactosamine, and D-glucuronic acid has been investigated by electron absorption spectroscopy at different metal to ligand ratios and pH values. In the case of D-glucuronic acid, a more detailed study was undertaken, using differential IR spe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785436
更新日期:1996-02-01 00:00:00
abstract::We explored the synergistic effect of serine combined with several selenocompounds or used alone on the expression of selenoprotein P (SelP) and glutathione peroxidase (GPx) in this study. We first compared the SelP and GPx expression difference between HepG2 and Hela cells treated with serine and finally chose HepG2 ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0665-8
更新日期:2016-10-01 00:00:00