Comparison of chromosome damage induced by three zinc compounds using human leukocyte culture.

Abstract:

:The degree of chromosome damage induced by three compounds of zinc (zinc chloride, zinc sulfate, zinc acetate) was compared in human leucocytes in vitro. Three concentrations of each salt, 3.0 x 10(-5)M, 3.0 x 10(-4)M, and 1.5 x 10(-3)M, were added to leukocyte cultures. The cells were harvested after 48 and 72 h and chromosome spreads were prepared following a colchicine-hypotonic-fixation-air drying-Giemsa staining schedule. The end point screened was chromosome aberrations. All three salts were lethal at the highest concentration. The degree of chromosome damage was directly proportional to the concentrations used for zinc sulfate and zinc acetate but not for zinc chloride.

journal_name

Biol Trace Elem Res

authors

Santra M,Talukder G,Sharma A

doi

10.1385/BTER:78:1-3:113

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

113-9

issue

1-3

eissn

0163-4984

issn

1559-0720

pii

BTER:78:1-3:113

journal_volume

78

pub_type

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