Abstract:
:Results from several medical investigations carried out using the Oxford scanning proton microprobe are presented, including maps of the hepatic copper-distribution in primary biliary cirrhosis and maps of the iron distribution in primary hemochromatosis. Preliminary studies of human nervous tissue reveal that morphologically recognizable structures can be differentiated using precision elemental mapping, and this may lead to a powerful new way of distinguishing subtle perturbations of structure and function. In further prelimianry studies, localized aluminum structures have been observed in Alzheimer's disease tissue at bulk levels of less than parts per million.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Vaux DJ,Grime GW,Watt Fdoi
10.1007/BF02796626subject
Has Abstractpub_date
1987-08-01 00:00:00pages
115-33issue
1eissn
0163-4984issn
1559-0720journal_volume
13pub_type
杂志文章abstract::Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:80:3:251
更新日期:2001-06-01 00:00:00
abstract::Zinc (Zn) is essential for development, growth, and reproduction. The Mexican government subsidizes micronutrient-fortified milk for risk groups, with positive effect on the targeted groups' plasma Zn level, inferring a good absorption is achieved although it has not being measured. The aim of this study was to determ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0356-x
更新日期:2015-11-01 00:00:00
abstract::The effect of manganese (Mn) supplementation on bone mineral density (BMD) and bone metabolism parameters was determined in ovariectomized Sprague-Dawley rats. Rats were divided into four groups (OVX, OVX+Mn, sham, sham+Mn) and fed with different intake levels of manganese (adequate 0.001% Mn, supplementation 0.01% Mn...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8119-6
更新日期:2008-07-01 00:00:00
abstract::Mannheimia haemolytica is the main bacterial pathogen isolated in bovine respiratory disease (BRD), a common disease affecting calves before weaning. Previous research has shown that experimental infection with bovine herpesvirus 1, a respiratory virus, decreases plasma zinc (Zn) levels. However, changes in plasma Zn ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02145-4
更新日期:2021-01-01 00:00:00
abstract::The influence of hair color on the trace elemental status in horse's hair has been studied. A current analytical technique such as particle-induced X-ray emission (PIXE) used in this study has provided reliable, rapid, easy, and relatively inexpensive diagnostic methods. Twenty-eight elements (Al, Br, Ca, Cl, Co, Cu, ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:103:2:169
更新日期:2005-02-01 00:00:00
abstract::In the present study, an investigation was undertaken to assess the efficacy on serum enzymes of colloidal bismuth subcitrate (CBS). CBS was administered with injections to male rats in 100-, 200-, 400-, 500-, and 1000-microg/L doses of bismuth. Rats were anesthetized at different intervals (24, 48, and 72 h) after CB...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:105:1-3:151
更新日期:2005-07-01 00:00:00
abstract::Two experiments were conducted to study the performance, antioxidant activity, and bone mineral variables in broilers fed organic trace minerals (OTM) at lowered concentrations in the diet. In experiment 1, a total of 1500 day-old broiler male chicks were randomly distributed into six groups with 10 replicates of 25 c...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02481-5
更新日期:2020-11-20 00:00:00
abstract::The present investigation was carried out to determine the molybdenum (Mo) status of blood plasma and milk of lactating cows at the Livestock Experimental Station, Khizer abad, Sargodha, Pakistan. Blood and milk from the lactating cows were sampled periodically after every month during winter so as to examine the effe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8874-z
更新日期:2011-10-01 00:00:00
abstract::In vivo X-ray fluorescence (XRF) techniques were used for biological monitoring of lead, cadmium, and mercury. Lead accumulates in bone, the level of which may thus be used for monitoring of exposure. However, there was no close association between lead levels in bone and exposure time, partly because of differences i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796636
更新日期:1987-08-01 00:00:00
abstract::It was determined if the sensitivity in macular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6-8-d-old or 3-4-wk-old macular mutant mouse to copper-induced toxicity was not affected by sex. However, 8-9-wk-old mutant females were more sensitive to copper-induced toxicity than ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783183
更新日期:1993-11-01 00:00:00
abstract::In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8686-1
更新日期:2011-05-01 00:00:00
abstract::Vanadium, a trace element in human cells and regarded as an essential nutrient, plays an active role in all tissues. It is known that peroxovanadate-nicotinic acid (POV), a complex compound of vanadium, can decrease hyperglycemia; however, its biochemical mechanism remains unclear. The object of the present study is t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:74:3:237
更新日期:2000-06-01 00:00:00
abstract::The aim of the present study was to evaluate the oxidative stress level and antioxidant trace elements status associated with lower airway disease in draft horses. For this purpose, venous blood samples were obtained from draft horses exhibiting signs of lower respiratory tract disorders (n = 83) and from control grou...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9471-0
更新日期:2012-12-01 00:00:00
abstract::The lipid and fatty acid composition of the blue mussels Mytilus edulis L. gills and digestive glands was evaluated after 24 and 72 h of cadmium (Cd) and copper (Cu) exposure. Mussels were exposed to different cadmium (10, 100, and 500 μg/L) and copper (5, 50, and 250 μg/L) concentrations. Similar stress response of p...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9727-3
更新日期:2013-08-01 00:00:00
abstract::Patients on total parenteral nutrition without Cr supplementation develop symptoms similar to those of diabetes. Zn has been implicated in diabetes because of its antioxidant properties and interaction with insulin. To study the effect of these metal ions on insulin signaling proteins, cultured mouse skeletal muscle c...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:101:1:19
更新日期:2004-10-01 00:00:00
abstract::Plasma zinc (Zn), copper (Cu), and magnesium (Mg) concentrations, copper/zinc ratio, and selenium (Se) status were studied in 44 vegetarians (22 males and 22 females) and their age- and sex-matched nonvegetarians in the Bratislava region (Slovakia). Vegetarians had statistically significant lower levels of plasma Zn a...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02789145
更新日期:1995-10-01 00:00:00
abstract::The present study was carried out to determine the effects of different sources of selenium (Se; sodium selenite [Na2SeO3] or selenomethionine [Se-Met]) supplementation on egg production, egg quality, levels of malondialdehyde (MDA), and Se in serum and egg yolk in heat-stressed Japanese quail (Coturnix coturnix japon...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8075-6
更新日期:2008-06-01 00:00:00
abstract::Previous studies revealed that Se was an important regulatory factor for glutathione peroxidase (GPx) genes. However, the relationship between Se concentrations and mRNA expression levels of GPxs were unclear in goats, especially the goats living in natural Se-enriched area. Thus, the aim of this study was to determin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9830-5
更新日期:2013-12-01 00:00:00
abstract::Lipid disturbance induced by high-fat diet is a worldwide problem, and it can induce inflammation and oxidative stress in vivo. Zinc is considered as an antioxidant, anti-inflammatory agent. Since matrix metalloprotease 2 (MMP2) and matrix metalloprotease 9 (MMP9)'s expressions are changed under many pathological cond...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0367-7
更新日期:2015-12-01 00:00:00
abstract::The accumulation of cadmium, its affinity for metallothioneins (MTs), and its relation to copper, zinc, and selenium were investigated in the experimental mudpuppy Necturus maculosus and the common toad Bufo bufo captured in nature. Specimens of N. maculosus were exposed to waterborne Cd (85 μg/L) for up to 40 days. E...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9461-2
更新日期:2012-12-01 00:00:00
abstract::Lipid peroxy radicals (ROO.) were detected by electron spin resonance (ESR) at low temperature after formation by addition of H2O2 into a suspension of mice lymphocytes. If lymphocytes were treated with selenomethionine (Se-Met) prior to addition of H2O2, ROO. formation was inhibited in a fashion that was dependent on...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783233
更新日期:1997-01-01 00:00:00
abstract::The primary objective of the present study is analysis of hair trace elements content in children with communication disorder (CD) and autism spectrum disorder (ASD). A total of 99 children from control, CD, and ASD groups (n = 33) were examined. All children were additionally divided into two subgroups according to a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0878-x
更新日期:2017-06-01 00:00:00
abstract::This study investigated whether boron would enhance the ability of 17beta-estradiol (E2) or parathyroid hormone (PTH) to improve bone quality in ovariectomized OVX rats. Adult OVX rats were treated for 5 wk with vehicle, boron (5 ppm as boric acid), E2 (30 microg/kg/d, sc), PTH (60 microg/kg/d, sc), or a combination o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:82:1-3:109
更新日期:2001-07-01 00:00:00
abstract::The intervention effect of fucoxanthin, which is reportedly a powerful antioxidant, on cadmium-induced thyroid damage in mice was evaluated. Animals (N = 120) were divided into control group (given pure water, N = 20) and CdCl2-exposed group (given CdCl2 orally at a dose of 30 mg/kg body weight (bw)/day for 30 days, N...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02291-9
更新日期:2020-07-21 00:00:00
abstract::Plasma and liver selenium of Wistar rats were determined after 1, 3, and 6 mo supplementation with 0.5, 2, 6, or 15 ppm selenium as sodium selenite in drinking water. Plasma selenium was not different from control values at additional intake of 0.5 ppm but increased above usual levels at higher intakes. A highly signi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784050
更新日期:1993-08-01 00:00:00
abstract::Since 1992, the International Atomic Energy Agency (IAEA) has been promoting studies of air pollution using a standard design of air sampler that provides separation on filters into two size fractions with cutoffs of 2.5 and 10 microns (approximately). These are the size ranges presently considered to have the most im...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784202
更新日期:1999-01-01 00:00:00
abstract::Modifications in the enzyme activity of lysozyme, a protein implied in the defence barrier of the organism, can be a good biomarker of alterations in the immune system as a result of exposure to toxic metal, such as lead. The aim of this work was to evaluate the effect of a 200 ppm dose of lead on lysozyme activity in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9446-1
更新日期:2012-12-01 00:00:00
abstract::It has become evident over the last two decades that there is an intimate relationship between the trace elements and cancer. Some trace elements have been shown to be carcinogens, others appear to provide protection against cancer. Profound changes in trace element concentrations and distribution occur in patients wi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783817
更新日期:1979-08-01 00:00:00
abstract::Selenium selenate was administered to streptozotocin-induced diabetic rats to assess its effects on the detrusor muscle. Thirty-two rats were divided into four groups of eight subjects each. The study animals were made diabetic by means of a single intravenous injection of streptozotocin (STZ). The responsiveness of t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:93:1-3:171
更新日期:2003-07-01 00:00:00
abstract::Guizhou black goats are essential to the production system in the Wumeng prairie in the Western China. This study aimed to determine the influence of nano-copper on antioxidant system in copper-deprived Guizhou black goats. We analyzed mineral contents in soil, forage, and goats' tissues. Blood parameters were also de...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02342-1
更新日期:2020-08-18 00:00:00