Abstract：
:Patients on total parenteral nutrition without Cr supplementation develop symptoms similar to those of diabetes. Zn has been implicated in diabetes because of its antioxidant properties and interaction with insulin. To study the effect of these metal ions on insulin signaling proteins, cultured mouse skeletal muscle cells was used as an in vitro model, as the tissue accounts for more than 80% of insulin-stimulated glucose disposal in the body. In the present study, it has been observed that both Cr and Zn, upon prolonged exposure, could stimulate tyrosine phosphorylation of insulin receptor (IR) even in the absence of insulin. Insulin-mediated IR tyrosine phosphorylation was enhanced by the treatment with both of the metal ions. Both Cr and Zn could phosphorylate insulin receptor substrate-1 (IRS-1). Phosphorylation of IRS-1 induced by metal ions was higher than that induced by insulin. Hence, both Cr and Zn were found to have insulin mimetic activity. Both of the metal ions were also found to potentiate insulin-mediated activation of IRS-1. The basal level of glucose uptake was also increased by prolonged treatment of the cells with the metal ions. The ions could also enhance the insulin-stimulated glucose uptake into the cells. Therefore, both Zn and Cr seem to have a positive effect on insulin signaling leading to glucose uptake.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Miranda ER,Dey CSdoi
10.1385/BTER:101:1:19subject
Has Abstractpub_date
2004-10-01 00:00:00pages
19-36issue
1eissn
0163-4984issn
1559-0720pii
BTER:101:1:19journal_volume
101pub_type
杂志文章abstract：:Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable Cu application. Cu-Z...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-0965-7
更新日期：2017-10-01 00:00:00
abstract：:Lead poisoning is a worldwide health problem, and its treatment is under investigation. The aim of this study was to access the efficacy of Coriandrum sativum (coriander) in reducing lead-induced changes in mice testis. Animal exposed to lead nitrate showed significant decrease in testicular SOD, CAT, GSH, total prote...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8553-0
更新日期：2010-09-01 00:00:00
abstract：:Nickel is an important kind of metal and a necessary trace element in people's production and livelihood; it is also a well-confirmed human carcinogen. In the past few years, researchers did a large number of studies about the molecular mechanisms of nickel carcinogenesis, and they focused on activation of proto-oncog...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9619-6
更新日期：2013-05-01 00:00:00
abstract：:The aim of this study was to investigate the protective effect of luteolin on liver Ca, Mg, Zn, Cu, Fe, and Mn content in mice with carbon tetrachloride (CCl4)-induced hepatotoxicity. Additionally, liver metallothionein (MT) expression was studied. Luteolin was administered intraperitoneally (i.p.) as a single 5- or 5...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8181-0
更新日期：2008-01-01 00:00:00
abstract：:Selenium (Se) is an essential trace element for both humans and animals. Se deficiency leads to myocardial injury, reproductive disorder, increased exudation, inflammatory injury, and other diseases. The present study analyzed the relationships of Se deficiency, inflammation, and smooth muscle contraction in the small...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02245-1
更新日期：2020-06-15 00:00:00
abstract：:Selenium was added to the feed of White Leghorn type chickens 1 day prior to challenge with either Escherichia coli or sheep erythrocyte antigen. The incidence of death or lesions was reduced from 86% to 21% at the optimal dose of selenium (0.4 mg/kg resulting in feed concentration of 0.45 mg/kg). After the chickens w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917469
更新日期：1997-09-01 00:00:00
abstract：:The trace element selenium is an essential micronutrient for human health and its low levels in serum are implicated in the pathogenesis of several chronic diseases. Therefore, the determination of total selenium in serum may contribute to the assessment of the health and nutritional status of certain populations. The...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8252-2
更新日期：2009-04-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of a daily intake of fluid and salt supplementation (FSS) on the deficiency of electrolytes, which is characterized by higher rather than lower plasma concentration of electrolytes during prolonged hypokinesia (HK) (decreased number of km taken per day). Forty long dist...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783342
更新日期：1998-07-01 00:00:00
abstract：:Concentrations of trace metals (Cu, Pb, Zn, Cd, Cr, Hg, and As) were determined for the first time in seawater, sediment, and Manila clam from Deer Island, Liaoning Province, China. The seawater, sediment, and clam samples were collected seasonally at three clam farming sites around Deer Island during 2010-2011. The a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9628-5
更新日期：2013-06-01 00:00:00
abstract：:Arsenic (As) is widely distributed in our living environment and is useful for industry, agriculture, medical treatment, and other fields. Arsenic trioxide (As2O3) is an existing form of As. Exposure to As2O3 has a toxic effect on humans and animals. It not only leads to skin cancer, peripheral vascular disease, hyper...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0462-9
更新日期：2016-03-01 00:00:00
abstract：:This study was undertaken to evaluate a systematic analysis of mineral and trace elements of individual functionally determined parts of adult temporal bone. Marked differences were observed in basic structural elements (Ca, P, Mg, and Zn) among different bone regions. The more so, molar Ca/P ratio was significantly d...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF03032672
更新日期：1991-04-01 00:00:00
abstract：:Sponge granuloma formation was compared in copper-deficient and copper-sufficient rats following feeding of respective diets for 20, 40, or 60 d. Body weight, total blood hemoglobin, and activities of ceruloplasmin and Cu, Zn-superoxide dismutase in plasma were monitored to ascertain copper deficiency. Mean granuloma ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990272
更新日期：1990-05-01 00:00:00
abstract：:In this article, we report the results of a case control study carried out on 290 Turkish pregnant women at 5-24 wk of gestation to determine their zinc, folic acid, and vitamin B12 levels in relation to their nutritional and socioeconomic status. The women were divided into two groups (n=145 each), depending on the s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:109:2:105
更新日期：2006-02-01 00:00:00
abstract：:The nuclear microscope is now gaining popularity in the field of life sciences. In particular, the combination of proton-induced X-ray emission to measure the elemental concentrations of inorganic elements, Rutherford backscattering spectrometry to characterize the organic matrix, and scanning transmission ion microsc...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02784192
更新日期：1999-01-01 00:00:00
abstract：:Scleroderma, sclerosis of the skin, is a severe autoimmune disease refractant to all kind of treatments. To study the in vivo effects of a combination of three oligoelements selenium (Se), zinc (Zn), and manganese (Mn) plus Lachesis muta venom (O-LM) on the bleomycin (BLM)-induced scleroderma mouse experimental model....
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9876-4
更新日期：2014-02-01 00:00:00
abstract：:Zinc uptake regulator (Zur) is a negative transcriptional regulator of bacteria that belongs to the FUR superfamily of proteins and regulates zinc (Zn) homeostasis under extreme Zn conditions. The Zur protein of Bacillus anthracis (BaZur) was though characterized previously, but the residues of this transcriptional re...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02427-x
更新日期：2020-10-14 00:00:00
abstract：:We investigated the rooting rate, the number of roots, and the state of growth of loquat (Eriobotrya japonica Lindi) plantlet in medium where La(NO3)3 (0.5-100.0 micromol/L) was added 20 d after transplanting. The activity of peroxidase, nitrate reductase, and the fresh weight of roots were determined 44 d after trans...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:89:3:277
更新日期：2002-12-01 00:00:00
abstract：:This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO4) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO4 strongly inhibited the replic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01728-0
更新日期：2020-02-01 00:00:00
abstract：:This experiment was conducted to evaluate the effects of heme and non-heme iron sources on growth performances, blood parameters, tissue mineral concentration, and intestinal morphology in weanling pigs. At 25 days of age, 32 newly weaned piglets (Duroc × Landrace × Yorkshire; 8.66 ± 0.59 kg) were allocated to one of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1385-z
更新日期：2019-02-01 00:00:00
abstract：:The objective of this study was to investigate the effects of dietary supplemental chromium (Cr) on growth performance, carcass traits, and meat quality of broilers reared under heat stress. A total of 252 1-d-old Cobb 500 commercial female broilers were randomly allotted by body weight (BW) to one of six replicate ca...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0443-z
更新日期：2016-03-01 00:00:00
abstract：:Zinc is a nutritionally essential trace element required for many biological functions to be successfully carried out. The aim of the present work was to study the influence of zinc on the intestinal absorption of L-threonine and on the aminopeptidase N activity in rabbit jejunum, after in vitro addition and/or oral a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784557
更新日期：1996-07-01 00:00:00
abstract：:Samples of Evernia prunastri, collected in a mountainous zone, were exposed in urban and highly industrialized areas in order to monitor the atmospheric pollution. Amounts of Cr, Mn, Fe, Ni, Cu, Zn, and Pb were determined by EDXRF spectrometry in secondary target excitation mode and in the thin film approach. An incre...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917318
更新日期：1994-10-01 00:00:00
abstract：:The purpose of the study was to determine the concentration of trace elements in serum samples of women who are chronic users of skin-whitening agents as well as the hepatic and renal effects of these agents on these women. The study was conducted among 23 skin-whitening users while 25 women served as the controls. Th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-8962-8
更新日期：2011-12-01 00:00:00
abstract：:One hundred and eighty Kunming mice were allotted to three groups in a randomized complete block design, including two treatments and one control. Mice in group 1 were fed a basal diet as control, while mice in groups 2 and 3 were fed the basal diet supplemented with 0.2 mg/kg selenium as sodium selenite (SS) or selen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0243-5
更新日期：2015-06-01 00:00:00
abstract：:The effects of selenium were investigated on three human colon cancer cell lines: Caco 2, HRT 18, and HT 29. At low concentrations (10-100 nM), selenium stimulated cell growth in serum-free medium. Thus, selenium is an essential trace element for cell proliferation. At higher concentrations, selenium inhibited cell gr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02919096
更新日期：1989-04-01 00:00:00
abstract：:Trace elements can influence dental health, possibly by altering tooth resistance during preeruptive development. Therefore, it was investigated whether lead and fluoride would be incorporated into the calcifying matrices or the cellular parts of tooth germs in vitro. Using laser microprobe mass analysis, the localiza...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917184
更新日期：1989-01-01 00:00:00
abstract：:A 6-week trial was conducted to compare the effect of selenium (Se) from hydroponically produced Se-enriched kale sprout (HPSeKS), sodium selenite (SS), and Se-enriched yeast (SeY) in laying hens. A total of 144 40-week-old hens were randomly divided into four groups, according to a completely randomized design. Each ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1069-0
更新日期：2018-03-01 00:00:00
abstract：:In the present study, we investigated the effects of Se-enriched Agaricus blazei Murill (Se-AbM) on liver injury in mice induced by acute alcohol administration. Mice received ethanol (5 g/kg body weight (BW)) by gavage every 12 h for a total of 3 doses. Se-AbM was administrated before ethanol administration. Subseque...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0022-8
更新日期：2014-07-01 00:00:00
abstract：:Measurement and monitoring of magnesium (Mg) are important to prevent the development of serious and potentially fatal complications in critically ill patients. Although ion-selective electrodes are available and earlier reports suggest that free ionized magnesium (iMg2+) is the most useful test to estimate Mg status,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:115:1:13
更新日期：2007-01-01 00:00:00
abstract：:The increase in the prevalence of metabolic disorders globally is becoming a public health concern. Previous studies have reported an association between environmental exposures to hazardous substances, including various heavy metals, and the risk for metabolic syndrome. However, reports on the contributions of cadmiu...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02502-3
更新日期：2021-01-06 00:00:00
