Effect of selenium on the growth of three human colon cancer cell lines.

Abstract:

:The effects of selenium were investigated on three human colon cancer cell lines: Caco 2, HRT 18, and HT 29. At low concentrations (10-100 nM), selenium stimulated cell growth in serum-free medium. Thus, selenium is an essential trace element for cell proliferation. At higher concentrations, selenium inhibited cell growth. The rate of 75Se uptake was the same in all of the cell lines studied, but the quantity incorporated differed. GSH-Px activity was dependent on the selenium content of the medium. DNA and protein synthesis paralleled the growth curve. Comparison with the curve of viability revealed that selenium inhibited cell growth in two ways: by inhibiting DNA synthesis, without affecting cell viability, and, at higher doses, by cytotoxicity.

journal_name

Biol Trace Elem Res

authors

Nano JL,Czerucka D,Menguy F,Rampal P

doi

10.1007/BF02919096

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

31-43

issue

1-2

eissn

0163-4984

issn

1559-0720

journal_volume

20

pub_type

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