Abstract：
:The aim of this study was to investigate the influence of Se deficiency on the transcription of inflammatory factors and selenoprotein genes in the kidneys of broiler chicks. One hundred fifty 1-day-old broiler chicks were randomly assigned to two groups fed with either a low-Se diet (L group, 0.033 mg/kg Se) or an adequate Se diet (C group, 0.2 mg/kg Se). The levels of uric acid (UA) and creatinine (Cr) in the serum and the mRNA levels of 6 inflammatory factors and 25 selenoprotein genes in the kidneys were measured as the clinical signs of Se deficiency occurred at 20 days old. The results indicated that the contents of UA and Cr in the serum increased in L group (p < 0.05), and the mRNA levels of the inflammatory factors (NF-κB, iNOS, COX-2, and TNF-α) increased in L group (p < 0.05). Meanwhile, the mRNA levels of PTGEs and HO-1 were not changed. In addition, 25 selenoprotein transcripts displayed ubiquitous expression in the kidneys of the chicks. The mRNA levels of 14 selenoprotein genes (Dio1, Dio2, GPx3, Sepp1, SelH, SelI, SelK, Sepn1, SelO, SelW, Sep15, SelT, SelU, and SelS) decreased, and 9 selenoprotein genes (GPx1, GPx2, GPx4, SelPb, Txnrd1, Txnrd2, Txnrd3, SPS2, and SelM) increased in L group (p < 0.05), but the Dio3 and Sepx1 mRNA levels did not change. The results indicated that Se deficiency resulted in kidney dysfunction, activation of the NF-κB pathway, and a change in selenoprotein gene expression. The changes of inflammatory factor and selenoprotein gene expression levels were directly related to the abnormal renal functions induced by Se deficiency.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Zhang JL,Xu B,Huang XD,Gao YH,Chen Y,Shan ASdoi
10.1007/s12011-015-0512-3subject
Has Abstractpub_date
2016-05-01 00:00:00pages
201-7issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-015-0512-3journal_volume
171pub_type
杂志文章abstract：:Present study investigates relationships between total and bioaccessibility of trace elements (Cd, Co, Cr, Cu, Mn, NI, Pb, V, and Zn) concentrations in sediment and their bioaccumulation in species in Shadegan wetland in southwest of Iran. Bioavailability factor (BAF) and translocation factor (TF) were calculated in p...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8795-x
更新日期：2011-09-01 00:00:00
abstract：:The degree of accumulation and distribution of Cd and Pb in the organs of young animals compared to the amount taken in with water or feed have not been thoroughly investigated yet. The experiment aimed to verify whether the source of toxic metals (feed, drinking water) administered to growing rats orally has an influ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0414-4
更新日期：2016-02-01 00:00:00
abstract：:A study was conducted to validate the effects of nano form of zinc (NZn) on nutrient digestibility, zinc retention, organ and serum zinc profile, and hepatic metallothionein gene expression in Wistar albino rats (WAR). Nano zinc (NZn) was synthesized through chemical method, by using 0.45 M zinc nitrate [Zn(NO3)2.6H2O...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1517-5
更新日期：2019-07-01 00:00:00
abstract：:The growth of the protozoan Blepherisma is stimulated by Lanthanum (La) at concentrations as low as 0.32 ppm. In mice Yttrium (Y) and Ytterbium (Yb) are absorbed, accumulated, and metabolized. Both rare earth elements (RE) exhibit a high affinity for teeth and bones, accumulation occurs and metabolism is slow. In the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795448
更新日期：1988-09-01 00:00:00
abstract：:Se is an important bioelement essential for a healthy immune system. Dietary Se influences both innate and adaptive immune responses. However, the effects of Se deficiency in chicken spleen are still unknown; thus, we designed an experiment to study the role of Se in chicken spleen. A total of 180 one-day-old sea blue...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1396-9
更新日期：2019-02-01 00:00:00
abstract：:The present study was undertaken to evaluate the in vitro availability of chemically varying forms of selenium (Se), supplemented in cow's milk. Two inorganic (selenite and selenate) and two organic (seleno-methionine [Se-Met] and seleno-cystine [Se-Cys]) Se sources were evaluated. The in vitro availability was estima...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02910666
更新日期：1997-07-01 00:00:00
abstract：:The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood. In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9834-1
更新日期：2013-12-01 00:00:00
abstract：:Plasma zinc (Zn), copper (Cu), and magnesium (Mg) concentrations, copper/zinc ratio, and selenium (Se) status were studied in 44 vegetarians (22 males and 22 females) and their age- and sex-matched nonvegetarians in the Bratislava region (Slovakia). Vegetarians had statistically significant lower levels of plasma Zn a...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/BF02789145
更新日期：1995-10-01 00:00:00
abstract：:A simple, quick procedure has been developed for preparation of human lenses for total chromium (Cr) analysis by electrothermal atomic absorption spectrometry (EAAS). This procedure involves wet ashing in a mini-autoclave with HNO3 and H2SO4. Recovery was 101.6%. This procedure is simple to carry out, does not generat...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784598
更新日期：1992-01-01 00:00:00
abstract：:In the current study, 48 male rats were classified into four groups (12 rats/group): 1-control group received 1 ml distilled water, 2-origanum oil group treated daily with oral dose of origanum oil (5 mg/kg) for 30 and 60 days, 3-mercuric chloride group treated daily with oral dose of mercuric chloride (4 mg/kg) for 3...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1067-2
更新日期：2018-03-01 00:00:00
abstract：:Differences in mineral nutrient composition of soils have been considered to affect health and population characteristics of free-ranging animals, particularly herbivores. Contents of Ca, Mg, and K in hair of female fawn white-tailed deer (Odocoileus virginianus) were measured for eight consecutive years to determine ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783968
更新日期：1998-06-01 00:00:00
abstract：:Selenium (Se) deficiency in the experimental models, Coturnix coturnix japonica and Corcyra cephalonica, resulted in impaired mitochondrial substrate oxidations and lowered thiol levels. Studies with respiratory inhibitors confirmed reduced mitochondrial electron transport enzyme activities, especially at cytochrome c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784077
更新日期：1996-03-01 00:00:00
abstract：:Intact and non-intact urinary stones richening with calcium oxalate were collected and characterized. The elemental analysis, phase quantifications, and function groups were determined by different spectroscopic techniques, namely: energy-dispersive X-ray fluorescence (EDXRF), the synchrotron radiation X-ray diffracti...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02424-0
更新日期：2020-10-10 00:00:00
abstract：:The aim of this study was to trace zinc nanocrystals in the anterior pituitary of zinc-deficient Wistar rats by using autometallographic technique. Male Wistar rats (30-40 days of age, pre-pubertal period) of 40-50 g body weight were divided into the following: the ZC (zinc control) group-fed with 100 ppm zinc in diet...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0881-2
更新日期：2017-06-01 00:00:00
abstract：:In the present world, X-rays have been regarded as one of the most efficient tools in medicine, industry and research. On the contrary, extensive human exposure to these rays is responsible for causing detrimental effects on physiological system. The aim of the present study was to investigate the role of zinc (Zn), i...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-0976-4
更新日期：2017-10-01 00:00:00
abstract：:This study aimed to investigate the effect of zinc (Zn), selenium (Se), and vitamin E (Vit E) administration on semen quality and fertility in male dromedary camels with impotentia generandi (IG, post-coital infertility). Factors that may affect response to treatment were investigated. Thirty-three IG-affected and fiv...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02276-8
更新日期：2020-07-06 00:00:00
abstract：:Two experiments were conducted to study the performance, antioxidant activity, and bone mineral variables in broilers fed organic trace minerals (OTM) at lowered concentrations in the diet. In experiment 1, a total of 1500 day-old broiler male chicks were randomly distributed into six groups with 10 replicates of 25 c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02481-5
更新日期：2020-11-20 00:00:00
abstract：:Among the trace elements, zinc is one of the most used elements in biological systems. Zinc is found in the structure of more than 2700 enzymes, including hydrolases, transferases, oxyreductases, ligases, isomerases, and lyases. Not surprisingly, it is present in almost all body cells. Preserving the stability and int...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-017-1119-7
更新日期：2018-05-01 00:00:00
abstract：:The purpose of this 42-day study was to investigate the effects of dietary excess vanadium on spleen growth and lesions by determining morphological changes and cell cycle of spleen. Four hundred twenty 1-day-old avian broilers were divided into six groups and fed on a corn-soybean basal diet as control diet or the sa...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8938-0
更新日期：2011-11-01 00:00:00
abstract：:Timed-mated Sprague-Dawley rats (60/group) were exposed to boric acid (BA) from gestational days (gd) 0 to 20. BA added to the diet (0, 0.025, 0.050, 0.075, 0.1, or 0.2%) yielded boron (B) intakes of <0.35 (control), 3, 6, 10, 13, or 25 mg B/kg body wt/d. Approximately one-half of the dams/group were terminated on gd ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783148
更新日期：1998-01-01 00:00:00
abstract：:Samples of Evernia prunastri, collected in a mountainous zone, were exposed in urban and highly industrialized areas in order to monitor the atmospheric pollution. Amounts of Cr, Mn, Fe, Ni, Cu, Zn, and Pb were determined by EDXRF spectrometry in secondary target excitation mode and in the thin film approach. An incre...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917318
更新日期：1994-10-01 00:00:00
abstract：:In order to study the metabolism of mercury (Hg), its affinity to metallothionein (MT), and its influence on levels of the essential metals copper and zinc in the brain tissue of rats exposed to elemental mercury (HgO) vapor was investigated. The major findings were: 1. After long-term exposure, about 40% of mercury w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789402
更新日期：1993-04-01 00:00:00
abstract：:In the present study, 15 different commercial tea brands sold in Khyber Pakhtunkhwa were collected from the markets. The samples were analyzed for the concentrations of ten selected heavy metals. The metal concentration showed a random distribution in all samples. The mean concentration of Cd, Cu, Mn, Pb, Zn, and Fe w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02059-1
更新日期：2020-11-01 00:00:00
abstract：:A review of the activity of metal compounds in mammalian cell transformation assays has been completed. Results from these assays appear to correlate well with the known carcinogenic activity displayed by specific metal compounds in vivo. Studies of cell transformation in vitro may provide information pertaining to th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783248
更新日期：1982-06-01 00:00:00
abstract：:Selenium is a trace element that, although toxic in higher concentrations, is essential for human and animal health. In this study, we looked at microarray-based gene expression patterns from liver and gastrocnemius tissues in mice fed either a selenium-deficient diet or diets containing sodium selenite, selenomethion...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8894-8
更新日期：2011-11-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of a daily intake of fluid and salt supplementation (FSS) on the deficiency of electrolytes, which is characterized by higher rather than lower plasma concentration of electrolytes during prolonged hypokinesia (HK) (decreased number of km taken per day). Forty long dist...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783342
更新日期：1998-07-01 00:00:00
abstract：:The effects of selenium were investigated on three human colon cancer cell lines: Caco 2, HRT 18, and HT 29. At low concentrations (10-100 nM), selenium stimulated cell growth in serum-free medium. Thus, selenium is an essential trace element for cell proliferation. At higher concentrations, selenium inhibited cell gr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02919096
更新日期：1989-04-01 00:00:00
abstract：:Water-borne arsenicosis is caused by the consumption of excess levels of inorganic arsenic from drinking water and is a worldwide public health issue. Arsenic exposure has recently attracted extensive attention due to its damage to the cardiovascular system. Vascular endothelial dysfunction (VED) is recognized as an i...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1559-8
更新日期：2019-08-01 00:00:00
abstract：:The current study aims to assess the concentration of cadmium (Cd) and lead (Pb) in five tissues of Cirrhinus mrigala, Labeo rohita, and Catla catla collected from fishponds of Jamshoro and Larkana, Sindh, Pakistan. Meanwhile, the levels of Cd and Pb in feeding materials, water, and sediments of fishponds of both area...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1628-z
更新日期：2019-10-01 00:00:00
abstract：:This study was designed to investigate the pro-inflammatory cytokines and their involvement in the cytotoxic potential of fluoride (F) in HeLa cells. HeLa cells were cultured with varying F concentrations (1-50 mg/L) for 48 h, and treatment effects were analyzed. The viability of HeLa cells was determined with a color...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0749-5
更新日期：2017-01-01 00:00:00
