Abstract：
:Nickel is an important kind of metal and a necessary trace element in people's production and livelihood; it is also a well-confirmed human carcinogen. In the past few years, researchers did a large number of studies about the molecular mechanisms of nickel carcinogenesis, and they focused on activation of proto-oncogenes and inactivation of anti-oncogenes caused by gene point mutation, gene deletion, gene amplification, DNA methylation, chromosome condensation, and so on that were induced by nickel. However, the researches on tumorigenic molecular mechanisms regulated by microRNAs (miRNAs) are rare. In this study, we established nickel-induced tumor by injecting Ni3S2 compounds to Wistar Rattus. By establishing a cDNA library of miRNA from rat muscle tumor tissue induced by Ni3S2, we found that the expression of miR-222 was significantly upregulated in tumor tissue compared with the normal tissue. As we expected, the expression levels of target genes of miR-222, CDKN1B and CDKN1C, were downregulated in the nickel-induced tumor. The same alteration of miR-222 and its target genes was also found in malignant 16HBE cells induced with Ni3S2 compounds. We conclude that miR-222 may promote cell proliferation infinitely during nickel-induced tumorigenesis in part by regulating the expression of its target genes CDKN1B and CDKN1C. Our study elucidated a novel molecular mechanism of nickel-induced tumorigenesis.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Zhang J,Zhou Y,Ma L,Huang S,Wang R,Gao R,Wu Y,Shi H,Zhang Jdoi
10.1007/s12011-013-9619-6subject
Has Abstractpub_date
2013-05-01 00:00:00pages
267-74issue
2eissn
0163-4984issn
1559-0720journal_volume
152pub_type
杂志文章abstract：:Although adriamycin (ADR) exhibits high anti-tumor efficacy in vitro, its clinical use in cancer chemotherapy is limited due to its high renal toxicity. This study investigated the mechanism of ADR nephropathy and the protective effect of selenium on ADR-induced kidney damage by analyzing of the relationship between s...
journal_title：Biological trace element research
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journal_title：Biological trace element research
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
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pub_type： 杂志文章,评审
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更新日期：1999-06-01 00:00:00
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更新日期：2015-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
