Diversity of inorganic arsenite biotransformation.

Abstract:

:Biotransformation of inorganic arsenic in mammals is catalyzed by three serial enzyme activities: arsenate reductase, arsenite methyltransferase, and monomethylarsonate methyltransferase. Our laboratory has purified and characterized these enzymes in order to understand the mechanisms and elucidate the variations of the responses to arsenate/arsenite challenge. Our results indicate a marked deficiency and diversity of these enzyme activities in various animal species.

journal_name

Biol Trace Elem Res

authors

Healy SM,Wildfang E,Zakharyan RA,Aposhian HV

doi

10.1007/BF02783907

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

249-66

issue

3

eissn

0163-4984

issn

1559-0720

journal_volume

68

pub_type

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