Abstract:
:Biotransformation of inorganic arsenic in mammals is catalyzed by three serial enzyme activities: arsenate reductase, arsenite methyltransferase, and monomethylarsonate methyltransferase. Our laboratory has purified and characterized these enzymes in order to understand the mechanisms and elucidate the variations of the responses to arsenate/arsenite challenge. Our results indicate a marked deficiency and diversity of these enzyme activities in various animal species.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Healy SM,Wildfang E,Zakharyan RA,Aposhian HVdoi
10.1007/BF02783907subject
Has Abstractpub_date
1999-06-01 00:00:00pages
249-66issue
3eissn
0163-4984issn
1559-0720journal_volume
68pub_type
杂志文章,评审abstract::In this study, hair levels of Cu and Zn were determined in healthy male and female individuals (n = 192) ages 3.6-14.5 yr and the correlations with Cu and Zn daily intakes were examined. Determinations of Cu and Zn concentrations were performed by way of atomic absorption spectrometry and X-ray fluorescence. Nutrition...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02950788
更新日期:1994-02-01 00:00:00
abstract::The aim of this work is to verify whether there are statistically significant correlations between the concentrations of lead in blood, urine, and hair in children. The sample collected in 2007 consists of 163 children of both sexes from 11-14-year-olds, living in three municipalities of Sardinia (Italy). Inductively ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-8988-y
更新日期:2011-12-01 00:00:00
abstract::We investigated the possible correlation between the leptin concentration and the Zn/Cu ratio in the plasma of women with thyroid disorder. Forty women with hypothyroidism (n = 20) or hypothyroidism (n = 20) and 20 euthyroid controls were recruited. The results showed that the women with thyroid disorder (hypothyroidi...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1385/BTER:75:1-3:99
更新日期:2000-07-01 00:00:00
abstract::The glutathione transferase (GST) activity of rat liver cytosolic preparations with ethacrynic acid (EA) and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydro-benzo(a)pyrene (BPDE) as substrates, increased by 125 and 350%, respectively, in animals that had been treated with a single intraveno...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917265
更新日期:1989-07-01 00:00:00
abstract::Human serum butyrylcholinesterase (BChE) has been converted into a stable but less active desensitized form when heated at 45 degrees C for 24 h. The desensitized BChE follows Michaelis-Menten kinetics, whereas native enzyme exhibits slightly negative cooperativity with respect to butyrylthiocholine binding. In this s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:93:1-3:55
更新日期:2003-07-01 00:00:00
abstract::The present study aimed to evaluate the effect of fluoride (F) on spermatogenesis in male rats. F- at 50 and 100 mg/L was administered for 70 days, after which the testicular and epididymis tissues were collected to observe the histopathological structure under a light microscope. The ultrastructure of the testis and ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1338-6
更新日期:2018-12-01 00:00:00
abstract::Selenoproteins and selenium (Se) play important roles in the immune system. Selenoprotein expression in the immune system of mammals is sensitive to dietary Se levels; however, little is known about the expression of selenoproteins and their immune functions in the chicken thymus. We assessed selenoprotein gene expres...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0282-y
更新日期:2015-09-01 00:00:00
abstract::Smoking is one of the major causes of mortality and numerous diseases, both directly and indirectly. The role of smoking as a significant risk factor is already known in several human diseases such as cardiovascular diseases, lung cancer, and chronic obstructive pulmonary disease. We aimed to compare the toxicity of h...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02537-6
更新日期:2021-01-20 00:00:00
abstract::This comparative study of the intestinal absorption of four toxic metals (aluminum, manganese, nickel, and lead) carried out in rats using the in situ intestinal perfusion technique was able to measure the partition of each metal between the intestine (intestinal retention), the blood circulation, and target tissues a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:99:1-3:157
更新日期:2004-07-01 00:00:00
abstract::Imbalance of zinc and copper status has been hypothesized in human hypertension. A case-control study was carried out to elucidate the possible relationship between zinc and copper status and essential hypertension. Thirty-one subjects affected by mild stable hypertension, pharmacologically untreated, were investigate...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02788959
更新日期:1995-08-01 00:00:00
abstract::To elucidate the element content of newborn blood vessels, umbilical arteries and veins in human umbilical cords, which had the advantage of easy sampling, were examined by ICP-AES. Umbilical cords were removed after birth. Mothers' ages ranged from 26 to 35 yr. It was found that the content of sulfur was the highest ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783875
更新日期:1999-09-01 00:00:00
abstract::Recently, considerable attention has been paid to the negative effects caused by the presence and constant increase in concentration of heavy metals in the environment, as well as to the determination of their content in human biological samples. In this paper, the concentration of chromium in samples of blood and int...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1328-8
更新日期:2018-12-01 00:00:00
abstract::The key role of osteoblasts in skeletal fluorosis makes the exploration of the possible mechanisms of the fluoride-induced oxidative stress of osteoblasts of great importance. In this article, the in vitro effects of fluoride on the oxidative stress of osteoblasts are presented. To study the inhibitory effect of baica...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02685921
更新日期:2007-04-01 00:00:00
abstract::The synthesis, characterization, anti-hyperglycemic activity, oxidative DNA damage capacity, and acute toxicity of chromium(III) malate complex [Cr2(LMA)3] were described. [Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on elemental analysis...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8916-6
更新日期:2011-11-01 00:00:00
abstract::The purpose of this study was to assess insoluble salts containing gadolinium (Gd(3+)) for effects on human dermal fibroblasts. Responses to insoluble Gd(3+) salts were compared to responses seen with Gd(3+) solubilized with organic chelators, as in the Gd(3+)-based contrast agents (GBCAs) used for magnetic resonance ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9176-9
更新日期:2012-02-01 00:00:00
abstract::Since 1992, the International Atomic Energy Agency (IAEA) has been promoting studies of air pollution using a standard design of air sampler that provides separation on filters into two size fractions with cutoffs of 2.5 and 10 microns (approximately). These are the size ranges presently considered to have the most im...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784202
更新日期:1999-01-01 00:00:00
abstract::The use of phosphate fertilizers is essential in agriculture, because they supply farmland with nutrients for growing plants. However, heavy metals might be included as impurities in natural materials and minerals, so heavy metals can also be present in phosphate fertilizers or other chemical fertilizers. The aim of t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9161-3
更新日期:2012-01-01 00:00:00
abstract::Relative stability of mineral elements in tissues is necessary for health. High static magnetic fields (HiSMFs) have been widely used in biomedical research and industry. However, the bioeffect of HiSMFs on animals is still unclear. In this study, we investigated the effects of HiSMF exposure on the levels of Mg, Fe, ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02469-1
更新日期:2021-01-07 00:00:00
abstract::The purpose of this research was to investigate whether copper (Cu) exposure could induce apoptosis via endoplasmic reticulum stress (ERS) in skeletal muscle of broilers. A total of 240 one-day-old chickens were randomly divided into four groups by free access; the diets are as follows: control diet (Cu 11 mg/kg, cont...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02076-0
更新日期:2020-12-01 00:00:00
abstract::Plasma and erythrocyte lipid peroxidation levels of 20 patients with histopathologically confirmed testis cancer and 20 healthy control individuals were studied between November 1995 and June 1997. The group with testis cancer had a mean age of 24.8+/-8.2 yr and the control group's mean age was 28.3+/-6.9 yr. Stage di...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1385/BTER:73:2:181
更新日期:2000-02-01 00:00:00
abstract::Selenoprotein K (SelK), a member of selenoprotein family, is identified as a single endoplasmic reticulum (ER) transmembrane protein. Although over-expression of SelK inhibits adherence and migration of human gastric cancer BGC-823 cells, the effects of SelK in human choriocarcinoma (CCA) are not well understood. In t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1155-3
更新日期:2018-07-01 00:00:00
abstract::The movement of copper and zinc from the fertilized egg into the developing embryo and the subsequent association of the two metals with metallothionein-like proteins (MT) of chick liver was investigated. Hepatic levels of MT in 1-d-old chicks, estimated from specifically bound(115m)Cd, were increased eightfold over e...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02988942
更新日期:1983-12-01 00:00:00
abstract::Adverse effects of mercury on female reproduction are reported; however, its effect on myogenic activity of uterus and mechanism thereof is obscure. Present study was undertaken to unravel the mechanistic pathways of mercuric chloride (HgCl2)-induced myometrial contraction in rats. Isometric tension in myometrial stri...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1379-x
更新日期:2019-02-01 00:00:00
abstract::Control of elemental impurities (EIs) in pharmaceutical herbal products is currently important but not a very popular topic in modern toxicological analysis. The occurrence and concentration of EIs in the pharmaceutical herbal products should be controlled and meet the standards of directive International Conference o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-1643-8
更新日期:2019-10-01 00:00:00
abstract::Epimedium polysaccharide (EPS) and isatis root polysaccharide (IRPS) were extracted, purified, and selenizingly modified by nitric acid-sodium selenite method to obtain nine selenizing EPSs (sEPSs), sEPS1-sEPS9 and nine selenizing IRPSs (sIRPSs), sIRPS1-sIRPS9, respectively. Their effects on chicken peripheral lymphoc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0511-4
更新日期:2016-05-01 00:00:00
abstract::Chromium picolinate is used in the poultry diet because of its antistress effects in addition to the fact that the requirement for it is increased during stress. This study was conducted to determine if the negative effects of high ambient temperature (34 degrees C) on egg production, egg quality, antioxidant status, ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:101:2:181
更新日期:2004-11-01 00:00:00
abstract::The effect of manganese (Mn) supplementation on bone mineral density (BMD) and bone metabolism parameters was determined in ovariectomized Sprague-Dawley rats. Rats were divided into four groups (OVX, OVX+Mn, sham, sham+Mn) and fed with different intake levels of manganese (adequate 0.001% Mn, supplementation 0.01% Mn...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8119-6
更新日期:2008-07-01 00:00:00
abstract::This study aimed to investigate the effects of vitamin D and magnesium co-supplementation on muscle strength and function, body composition, and inflammation in vitamin D-deficient middle-aged women. In this study, 83 healthy middle-aged women (40-55 years) with vitamin D deficiency were randomly assigned into two gro...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02387-2
更新日期:2020-09-21 00:00:00
abstract::It has become evident over the last two decades that there is an intimate relationship between the trace elements and cancer. Some trace elements have been shown to be carcinogens, others appear to provide protection against cancer. Profound changes in trace element concentrations and distribution occur in patients wi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783817
更新日期:1979-08-01 00:00:00
abstract::A cohort study on platers in Tokyo was carried out using the records of the Tokyo Health Insurance Society of Plating Industry. The type of work and chromium-exposure history of each member of this society was investigated by a questionnaire sent to the manager of each factory. The recovery rate of the questionnaire w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783841
更新日期:1979-03-01 00:00:00