Abstract：
:The effect of manganese (Mn) supplementation on bone mineral density (BMD) and bone metabolism parameters was determined in ovariectomized Sprague-Dawley rats. Rats were divided into four groups (OVX, OVX+Mn, sham, sham+Mn) and fed with different intake levels of manganese (adequate 0.001% Mn, supplementation 0.01% Mn) for 12 weeks. BMD of the lumbar vertebrae, femur, and tibia were significantly lowered in ovariectomized rats compared to the sham group. In addition, BMD of the lumbar vertebrae was significantly increased by Mn supplementation in the sham groups. Serum C-telopeptide cross-links of type I collagen (CTx), bone resorption biomarker, alkaline phosphatase (ALP), and bone formation biomarkers were not significantly different among the four groups. However, serum osteocalcin, a more sensitive bone formation biomarker, was significantly increased by Mn supplementation. To summarize, Mn supplementation resulted in increased BMD and bone formation. Based on our findings, more research is needed to better understand the effects of manganese supplementation on bone formation and resorption.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Bae YJ,Kim MHdoi
10.1007/s12011-008-8119-6subject
Has Abstractpub_date
2008-07-01 00:00:00pages
28-34issue
1eissn
0163-4984issn
1559-0720journal_volume
124pub_type
杂志文章abstract：:The study was undertaken to investigate the influence of alpha-tocopherol on zinc, copper, iron, calcium, magnesium, and potassium concentrations in serum of rats with bleomycin-induced pulmonary fibrosis. Fourteen Wistar albino rats were randomly divided into two groups of seven animals each. The first group was trea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:114:1:175
更新日期：2006-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:81:1:29
更新日期：2001-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1255-8
更新日期：2018-10-01 00:00:00
abstract：:Diabetic osteoporosis (DOP) is a complication of diabetes, with the characteristics of bone mineral density (BMD) reduction and bone structure destruction. Zinc was reported has a benefit effect on postmenopausal osteoporosise, it was also has hypoglycemic effect, whether zinc was beneficial on diabetes-induced osteop...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01810-7
更新日期：2020-04-01 00:00:00
abstract：:The effects of zinc on growing rats were characterized using the dietary zinc-deficient (ZD) and Zinc-overdose (ZO) models. Zinc deficiency had negative effects on the host final body weight and liver zinc content, whereas zinc overdose had positive effects. In order to identify the molecular changes in the liver resp...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02686028
更新日期：2007-02-01 00:00:00
abstract：:Heavy metals are the most common form of aquatic pollutants and are of great health risk to consumers of contaminated sea food. This study investigated the level of heavy metals in three species of catfishes Chrysichthys nigrodigitatus (marine catfish), Clarias gariepinus (African catfish), and Schilbe mystus (silver ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1484-x
更新日期：2019-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783916
更新日期：1999-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8252-2
更新日期：2009-04-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF03032691
更新日期：1991-05-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02152-5
更新日期：2021-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:98:3:229
更新日期：2004-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9668-x
更新日期：2013-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9671-2
更新日期：2013-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0096-3
更新日期：2014-11-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783193
更新日期：1993-11-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784557
更新日期：1996-07-01 00:00:00
abstract：:Pituitary dwarfism (hGHD) is known to be associated with trace element deficiency, which causes improper functioning of the involved endocrine system. Previously, we reported on the head hair concentrations of zinc, copper, manganese, and iron from a total of 418 normal subjects (154 male and 264 female). In this repo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:85:2:127
更新日期：2002-02-01 00:00:00
abstract：:The aim of the study has been to determine and compare the influence upon the kidney antioxidative system, exercised by administration of vitamin E, and vitamin E in combination with methionine, under conditions of oxidative stress induced by sodium fluoride. The experiment was carried out on Wistar FL rats (adult mal...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-8030-6
更新日期：2008-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1995-04-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Biological trace element research
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更新日期：2005-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0749-5
更新日期：2017-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917291
更新日期：1989-07-01 00:00:00
abstract：:Analyzing the concentrations of heavy metals in the sera of umbilical cord blood samples can provide useful information about prenatal exposure to environmental agents. An analytical method based on ICP-MS to simultaneously determine multiple elements in umbilical cord blood samples was developed for assessing the in ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0853-6
更新日期：2017-05-01 00:00:00
abstract：:The aim of this study was to evaluate the impact of three different chromium forms as chromic chloride (CrCl), chromium picolinate (CrPic), and a newly synthesized complex of chromium chelated with small peptides (CrSP) on glucose uptake and metabolism in vitro. In cultured skeletal muscle cells, chromium augmented in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8357-2
更新日期：2009-11-01 00:00:00
abstract：:The solubility of both free and low molecular weight ligand complexed calcium, magnesium, and zinc in skimmed human and bovine milks over intestinal luminal pH ranges (approximately 3-7) was measured using ultrafiltration techniques. Some of the experimental difficulties associated with the separation of labile metal ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02925450
更新日期：1989-01-01 00:00:00
abstract：:Fluoride compounds are abundant and widely distributed in the environment at a variety of concentrations. Further, fluoride induces toxic effects in target organs such as the liver. In this study, we investigated liver histopathology, DNA damage, apoptosis, and the mRNA and protein expressions of caspase-3 and -9 in t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0265-z
更新日期：2015-08-01 00:00:00
abstract：:The aim of present study was to compare the level of manganese (Mn) with thyroid functions, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxin (FT4) of females having hyper- (HPRT) and hypothyroid (HPOT) disorder. For comparative study, females of the same age group (16-30 years) having ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0277-8
更新日期：2015-10-01 00:00:00
abstract：:This study aimed to investigate the effects of a combination of a dairy product fermented by lactobacilli (DFL) and galactooligosaccharides (GOS) on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor (PPI). Three-week-old male rats were assigned to receive one of six diets: a cont...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9681-0
更新日期：2013-06-01 00:00:00
abstract：:Wistar male rats were exposed to nickel oxide (NiO) aerosols (mass median aerodynamic diameter, 1.2 μm). The average exposure concentration was controlled from low level (0.6 mg/m(3)) to high level (8.0 mg/m(3)) and total exposure time ranged from 140 to 216 h. Some rats were sacrificed just after the exposure, wherea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916542
更新日期：1985-02-01 00:00:00
