Study of chemical species of iodine in human liver.

Abstract:

:The distribution and chemical species of iodine in various subcellular fractions of human liver were studied by using epithermal neutron activation analysis combined with chemical and biochemical separation techniques, such as gradient centrifugation and gel chromatography. It was found that the total iodine content orders in various subcellular fractions is as follows: nuclei > cytosol > mitochondria > lysosome > microsome. In the lysosomal fraction, iodine is mainly bound to macromolecules, whereas in the nuclei and mitochondrial fractions, mainly with lower-molecular-weight organic compounds. In the cytosol fraction, iodine is combined with three proteins, in which iodine is chiefly bound with mid- and high-molecular-weight proteins.

journal_name

Biol Trace Elem Res

authors

Hou X,Chen C,Ding W,Chai C

doi

10.1007/BF02783916

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

69-76

issue

1

eissn

0163-4984

issn

1559-0720

journal_volume

69

pub_type

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