Chromosomal aberrations induced by cobaltous chloride in mice in vivo.

Abstract:

:The effects of cobaltous chloride in inducing chromosomal aberrations were observed on laboratory bred mice in vivo after single oral administration of different fractions (1/10, 1/20, 1/40) of the lethal toxic dose of the salt. Bone marrow cells were flushed out and processed for chromosome studies following colchicine, hypotonic, giemsa, air drying procedure. The parameters screened were chromosomal aberrations, with and without gaps and break per cell. Slides were screened after the expiry of 6, 12, 18, and 24 h. Statistical analysis indicated the clastogenic effects of the salt. The degree of chromosome damage was directly related to the concentration, and also to the period after administration. The different stages of the cell cycle were affected.

journal_name

Biol Trace Elem Res

authors

Palit S,Sharma A,Talukder G

doi

10.1007/BF03032691

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

139-45

issue

2

eissn

0163-4984

issn

1559-0720

journal_volume

29

pub_type

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