Abstract：
:AFB1 is a mycotoxin which exerts their cytotoxicity through increasing oxidative damage in target organ. Kidney is one of target organs vulnerable to damage caused by AFB1. In this study, Madin-Darby canine kidney (MDCK) cells were used to evaluate the AFB1-induced cell damage by the MTT assay. The results revealed that the toxic effect of AFB1 on MDCK cells is both dose and time dependent. Half maximal toxic concentration (IC50) was noted at 0.25 μg/ml of AFB1. Further, protective effect of six different concentrations (0.2, 0.8, 1, 2, 4, and 8 μM) of selenomethionine (SeMet) was observed against 0.25 μg/ml of AFB1-induced damage. The results showed that 0.25 μg/ml of AFB1 caused significant increase in oxidative stress, which was demonstrated by significant increase of malondialdehyde (MDA) level, reduction of intracellular GSH level, as well as GPX1 activity and mRNA level in MDCK cells when compared with control. SeMet protected the cells from AFB1-induced oxidative damage in a dose-dependant manner. Good protection could be achieved between 1 and 4 μM of concentration. Amid this range, MDA level significantly decreased while intracellular GSH level and GPX1 activity in addition to mRNA level significantly increased. Moreover, cell viability was significantly improved. It could be concluded that SeMet is a potential antioxidative agent to alleviate AFB1-induced oxidative stress.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Parveen F,Nizamani ZA,Gan F,Chen X,Shi X,Kumbhar S,Zeb A,Huang Kdoi
10.1007/s12011-014-9887-9subject
Has Abstractpub_date
2014-03-01 00:00:00pages
266-74issue
3eissn
0163-4984issn
1559-0720journal_volume
157pub_type
杂志文章abstract：:The solubility of both free and low molecular weight ligand complexed calcium, magnesium, and zinc in skimmed human and bovine milks over intestinal luminal pH ranges (approximately 3-7) was measured using ultrafiltration techniques. Some of the experimental difficulties associated with the separation of labile metal ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02925450
更新日期：1989-01-01 00:00:00
abstract：:Aspirin is widely used as an antiinflammatory drug especially in children with rheumatic fever arthritis. The diminishing effects of aspirin on antioxidant enzymes and hepato-renal systems at high doses are well-known. It is now evident that the damage at antioxidant system worsens the clinical picture of the disease ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8115-x
更新日期：2008-07-01 00:00:00
abstract：:The influence of several commercial albumin preparations on the ferroxidase activity of ceruloplasmin (ferroxidase I, ferrous: O2 oxidoreductase EC 1.16.3.1) at pH 6.0 was determined using ferric-transferrin formation. The ability of several albumin preparations to inhibit the ferroxidase activity of ceruloplasmin dif...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916628
更新日期：1983-04-01 00:00:00
abstract：:This experiment was designed to assess the effect of chronic fenvalerate toxicity on tissue Cu concentration in goats and to explore the pathways responsible for it. A significant decrease in tissue Cu concentration of kidney, heart, and brain while an increase in the liver were recorded in fenvalerate intoxicated goa...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8629-x
更新日期：2010-12-01 00:00:00
abstract：:The objective of this study was to examine relations between basal metabolic rate (BMR) and cadmium (Cd) accumulation in the liver, kidneys, and duodenum in mice. The 5-month-old mice selected for high (H) and low (L) BMR were exposed for 8 weeks to 0, 10, and 100 μg Cd/mL of drinking water. The H-BMR mice showed sign...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9061-6
更新日期：2011-12-01 00:00:00
abstract：:Plasma chromium concentrations have been determined for 150 patients. These were subjected to coronary artery cineangiography and thereby divided into three groups: group CAD (those with coronary artery disease), group HD (those with heart disease, but no CAD) and group N (those with no CAD and no HD). Weighted, avera...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02989260
更新日期：1984-10-01 00:00:00
abstract：:In the present study, aluminum (Al) accumulation has been examined after aluminum loading in mice. The kidney, liver, and brain aluminum levels for mice that had been treated orally with aluminum hydroxide for 105 d and for the control group were determined using graphite furnace atomic absorption spectrophotometry (G...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917223
更新日期：1994-04-01 00:00:00
abstract：:Several epidemiological studies have shown that exposure to electromagnetic radiation (EMR) can be harmful to human health. The purpose of this study was to examine oxidative parameters and apoptosis induced by EMR in human kidney embryonic cells (HEK293) and to investigate whether zinc (Zn) has protective effect on E...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01811-6
更新日期：2020-04-01 00:00:00
abstract：:The effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using Akt2 and IRS1 gene expression methods in streptozotocin-induced diabetic rats. Fifty rats were randomly divided into five experimental groups: 1, non-diabetic control (NDC); 2, Mg2+-treated non-diabet...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1555-z
更新日期：2019-08-01 00:00:00
abstract：:Accumulation of lanthanum oxide nanoparticles (La2O3NPs) in the femur bone of rats after 30 days of oral administration was explored. Also, the influence of La2O3NPs on macro and trace elements in the rats' femur bone was assessed. Inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma op...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01907-z
更新日期：2020-07-01 00:00:00
abstract：:The decline in fish population because of water contamination is problem. As a result of direct exposure in water, it has been readily accepted that the gills are the main site of water contamination and toxicity (e.g., metal ions). In the present study, we investigated metal ion contamination on the functional capaci...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:100:3:229
更新日期：2004-09-01 00:00:00
abstract：:In present study, the levels of some toxic elements in 19 different home-made cosmetic products (spray hair dye, henna, tattoo, eyeliner, eye mascara, smear, lip moisturizer, and lipstick) were analyzed by inductively coupled plasma mass spectrometric (ICP-MS) after microwave digestion. The ICP-MS results were verifie...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02357-8
更新日期：2020-09-05 00:00:00
abstract：:Despite the name, rare earth elements are relatively abundant in soil. Therefore, these elements might interact with biosphere during the history of life. In this study, we have examined the effect of rare earth ions on the growth of bacteria, fungi and soil nematode. All rare earth ions, except radioactive promethium...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0727-y
更新日期：2016-12-01 00:00:00
abstract：:Various studies indicate the role of manganese (Mn) in the virulence of pathogens. Salmonella is an intracellular pathogen which is able to multiply within the macrophages. The present study was therefore, designed to assess the effect of Mn supplementation on Salmonella-macrophage interactions particularly in referen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8406-x
更新日期：2010-01-01 00:00:00
abstract：:The present study was devoted to investigate the PTE concentrations including cadmium (Cd), chromium (Cr), copper(Cu), iron (Fe), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), arsenic(As), and zinc (Zn) among six types of edible wild, 23 cultivated mushroom samples collected from Iran's market by the aid of an...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02130-x
更新日期：2021-01-01 00:00:00
abstract：:An external-sample liquid scintillation (LS) counting for the gamma emitter 75Se has been developed. An expressly designed well-type LS vial and a 2,5-diphenyoxazole-1,4-bis(5-phenyl-2-oxazoyl)-benzene-xylene solution containing 35% tertrabutylzinn allow 75Se to be counted in a standard LS counter with counting effici...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:77:3:287
更新日期：2000-12-01 00:00:00
abstract：:The incorporation of(3)H-thymidine into DNA in the brains of the 17-day and 20-day old rat fetuses was significantly reduced by maternal zinc restriction during pregnancy. The activity of the enzyme thymidine kinase (EC 2.7.1.21) was similarly reduced in the zine-deprived fetal brains on days 14 and 20 of gestation, b...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789032
更新日期：1980-03-01 00:00:00
abstract：UNLABELLED:Limited data are available indicating the effects of chromium administration on endocrine profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). This study was done to assess the effects of chromium administration on endocrine profiles, biomarkers of inf...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-015-0570-6
更新日期：2016-07-01 00:00:00
abstract：:Atomic absorption spectrometry was used in a quantitative study of zinc, magnesium, and manganese on 71 postmortal human aortas. Samples were obtained from accident victims 35-65 years of age. Fibrous plaques had higher levels of all three elements when compared to normal aortic tissue. The difference was significant ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916613
更新日期：1989-12-01 00:00:00
abstract：:Present study investigates relationships between total and bioaccessibility of trace elements (Cd, Co, Cr, Cu, Mn, NI, Pb, V, and Zn) concentrations in sediment and their bioaccumulation in species in Shadegan wetland in southwest of Iran. Bioavailability factor (BAF) and translocation factor (TF) were calculated in p...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8795-x
更新日期：2011-09-01 00:00:00
abstract：:Using the dimethylbenz(a)anthracene-induced mammary tumor model in rats, our studies indicated that there was a dose-response relationship between dietary selenium supplementation and the inhibition of mammary carcinogenesis. The degree of inhibition was proportional to the level of dietary selenium up to 5 ppm, at wh...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02987217
更新日期：1983-08-01 00:00:00
abstract：:Kashin-Beck disease (KBD) is an endemic, degenerative osteoarthropathy, and particularly seen in China. A deficiency of selenium and iodine is implicated as the main etiological factor for KBD. This meta-analysis aimed to evaluate the differences in the selenium and iodine levels between patients with KBD and healthy ...
journal_title：Biological trace element research
pub_type： 杂志文章,meta分析
doi：10.1007/s12011-015-0463-8
更新日期：2016-03-01 00:00:00
abstract：:To examine whether the calcium accumulation in the arteries is related to the way of walk or not, the calcium contents were determined in various arteries of Japanese monkeys of quadrupedal walk by inductively coupled plasma-atomic emission spectrometry. Japanese monkeys consisted of five males and four females, rangi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:82:1-3:077
更新日期：2001-07-01 00:00:00
abstract：:Extracellular Ca2+-influx induced by trivalent metal ions (Fe3+, Al3+, Cr3+, In3+, Ga3+, and La3+) in Ehrlich carcinoma cells is enhanced by ATP. This action seems to be related to the high coordination capacity of the ATP ligand that inhibits the polymerization of the solvated cations taking place at physiological pH...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02820027
更新日期：1998-04-01 00:00:00
abstract：:Analyzing the concentrations of heavy metals in the sera of umbilical cord blood samples can provide useful information about prenatal exposure to environmental agents. An analytical method based on ICP-MS to simultaneously determine multiple elements in umbilical cord blood samples was developed for assessing the in ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0853-6
更新日期：2017-05-01 00:00:00
abstract：:Organotin compounds are highly versatile group of organometallic chemicals used in industrial and agricultural applications. Their endocrine-disrupting effects are well known and their extensive uses as biocide materials, e.g., in antifouling paints, for many years have led to serious environmental problems. So far, a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0144-z
更新日期：2014-12-01 00:00:00
abstract：:Animal feed has traditionally been supplemented with trace elements at dietary concentrations well above physiological needs. However, environmental concerns have led to calls for better adjustment of mineral supplementation to actual physiological needs and, in this context, consideration of breed-related differences...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1276-3
更新日期：2018-11-01 00:00:00
abstract：:Neonatal uptake of mercury (Hg) from milk was examined in a pregnant sheep model, where radioactive mercury (Hg203)/silver tooth fillings (amalgam) were newly placed. A crossover experimental design was used in which lactating ewes nursed foster lambs. In a parallel study, the relationship between dental history and b...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785388
更新日期：1997-02-01 00:00:00
abstract：:In this article, we report the results of a case control study carried out on 290 Turkish pregnant women at 5-24 wk of gestation to determine their zinc, folic acid, and vitamin B12 levels in relation to their nutritional and socioeconomic status. The women were divided into two groups (n=145 each), depending on the s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:109:2:105
更新日期：2006-02-01 00:00:00
abstract：:The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, so...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:80:1:53
更新日期：2001-04-01 00:00:00
