Abstract:
:The effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using Akt2 and IRS1 gene expression methods in streptozotocin-induced diabetic rats. Fifty rats were randomly divided into five experimental groups: 1, non-diabetic control (NDC); 2, Mg2+-treated non-diabetic control (Mg-NDC); 3, chronic diabetic (CD); 4, Mg2+-treated chronic diabetic (Mg-CD); and 5, insulin-treated chronic diabetic (Ins-CD). Streptozotocin was used to induce diabetes. The Mg-CD and Mg-NDC groups received 10 g/l of MgSO4 added to drinking water. The Ins-CD group received 2.5 U/kg of insulin twice a day. Blood glucose level and body weight were measured every week. The intraperitoneal glucose tolerance test (IPGTT) was performed after 16 weeks. MgSO4 administration improved the blood glucose level and IPGTT. It also increased Akt2 and IRS1 genes as well as protein expression. Insulin lowered the blood glucose level and increased IRS1 gene and protein expression, but did not affect Akt2 gene and protein expression. Glucose reduction after Mg therapy may be mediated, at least partially, via IRS1 and Akt2 genes and protein stimulation. In insulin-treated rats, insulin resistance was not significant due to the absence of Akt2 gene expression.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Kamran M,Kharazmi F,Malekzadeh K,Talebi A,Khosravi F,Soltani Ndoi
10.1007/s12011-018-1555-zsubject
Has Abstractpub_date
2019-08-01 00:00:00pages
396-404issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-018-1555-zjournal_volume
190pub_type
杂志文章abstract::The efficacy of selenate and other divalent anions to stimulate the efflux of radiolabeled sulfate from lactating rat mammary tissue slices has been examined. Both selenate and sulfate markedly increased the fractional release of sulfate via a system that is temperature-sensitive and sensitive to the anion-exchange in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917205
更新日期:1990-03-01 00:00:00
abstract::It has been demonstrated that zinc exerts its beneficial influence on skin fibroblasts. Propolis, a complex mixture of plant-derived and bees' products, was reported to stimulate cicatrization processes in skin and prevent infections. The aim of this study was to find out how zinc and propolis influence human skin fib...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0019-3
更新日期:2014-07-01 00:00:00
abstract::The effect of maternal dietary selenium (Se) and gestation on the concentrations of Se and zinc (Zn) in the porcine fetus were determined. Mature gilts were randomly assigned to treatments of either adequate (0.39 ppm Se) or low (0.05 ppm Se) dietary Se. Gilts were bred and fetuses were collected throughout gestation....
journal_title:Biological trace element research
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更新日期:2004-01-01 00:00:00
abstract::Auxiliary enzymes participate in β-oxidation of unsaturated fatty acids. The objective of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on Δ(3)Δ(2)-enoyl-CoA isomerase (ECI) in the liver and other tissues. Five groups of eight weanling rats each were fed...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9940-8
更新日期:2014-06-01 00:00:00
abstract::The liver of Hooded Seal (Cystophora cristata) consists of six lobes of unequal sizes. Extensive sampling by means of cutout samples covering the depth horizon 2-30 mm below liver surface indicates that the liver may be considered homogeneous as to concentrations of zinc, cadmium, mercury, and selenium (residuals of o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789141
更新日期:1990-01-01 00:00:00
abstract::Molybdenum (Mo) is an essential element for human beings and animals; however, high dietary intake of Mo can lead to adverse reactions. Cadmium (Cd) is harmful to health. To investigate the toxicity of Mo combined with Cd in duck kidneys, 240 ducks were randomly divided into six groups and treated with a commercial di...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0348-x
更新日期:2015-11-01 00:00:00
abstract::Information on cadmium (Cd) uptake and transport is essential to understand better the physiology of Cd tolerance in plants. In this study, Cd uptake, translocation, and tolerance were investigated in AHA1 (Arabidopsis plasma membrane H(+)-ATPase gene) overexpressed plants. Exposed to 10 µM CdCl(2), AHA1OX showed a hi...
journal_title:Biological trace element research
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doi:10.1007/s12011-010-8657-6
更新日期:2011-02-01 00:00:00
abstract::The abnormal metabolism of metal ions plays an important role in health and disease conditions; hence, the studies about them have received much interest. The objective of this study was to evaluate the association between trace and toxic elements zinc (Zn), cadmium (Cd), selenium (Se), and mercury (Hg) in biological ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0048-y
更新日期:2014-08-01 00:00:00
abstract::We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 m...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02789076
更新日期:1995-04-01 00:00:00
abstract::The present study was devoted to investigate the PTE concentrations including cadmium (Cd), chromium (Cr), copper(Cu), iron (Fe), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), arsenic(As), and zinc (Zn) among six types of edible wild, 23 cultivated mushroom samples collected from Iran's market by the aid of an...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02130-x
更新日期:2021-01-01 00:00:00
abstract::The objective of the study was analysis of hair trace elements content in children with goiter living in Aktubinsk region. Children with goiter and age- and sex-adjusted controls were involved in the current study. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. Thyroid vol...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-016-0711-6
更新日期:2016-12-01 00:00:00
abstract::Cadmium (Cd) exposure has been recognized to result in a wide variety of cellular responses, including oxidative stress and body weight loss. The aim of the present study was to examine the effect of lycopene supplementation on the antioxidant defense system, lipid peroxidation (LPO) level, nitric oxide (NO), tumor ne...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-0027-7
更新日期:2007-08-01 00:00:00
abstract::Selenium exerts many, if not most, of its physiological functions as a selenocysteine moiety in proteins. Selenoproteins are involved in many biochemical processes including regulation of cellular redox state, calcium homeostasis, protein biosynthesis, and degradation. A neurodevelopmental syndrome called progressive ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9920-z
更新日期:2014-05-01 00:00:00
abstract::The purpose of this study was to analyze the existing studies and to investigate the relationship between children's full-scale intelligence quotient (FIQ), verbal IQ (VIQ), and performance IQ (PIQ) and their blood lead (Pb) and zinc (Zn) levels. All documents in Chinese and English were collected from the PubMed, Web...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12011-017-1093-0
更新日期:2018-04-01 00:00:00
abstract::Differences in mineral nutrient composition of soils have been considered to affect health and population characteristics of free-ranging animals, particularly herbivores. Contents of Ca, Mg, and K in hair of female fawn white-tailed deer (Odocoileus virginianus) were measured for eight consecutive years to determine ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783968
更新日期:1998-06-01 00:00:00
abstract::Nonenzymatic glycation of long-lived proteins has been implicated in several complications related to age and diabetes. Dicarbonyl compounds such as methylglyoxal (MGO) have been identified as the predominant source for the formation of advanced glycation end-products (AGEs) in various tissues. We investigated the eff...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8915-7
更新日期:2011-11-01 00:00:00
abstract::Since chromium(VI) is unreactive toward DNA under physiological conditions in vitro, the ability of carcinogenic chromium(VI) compounds to damage DNA depends on the presence of cellular redox components that reduce chromium(VI) to reactive species capable of interacting with DNA. We have examined the role of glutathio...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02917282
更新日期:1989-07-01 00:00:00
abstract::Plasma concentrations of a zinc carrier peptide, namely thymulin, were measured according to a bioassay in young donors, healthy elderly, and patients with senile dementia of Alzheimer's type (SDAT). Thymulin is a hormone released by thymic epithelial cells and its biological activity on cells of immune system is depe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790147
更新日期:1996-01-01 00:00:00
abstract::Plasma zinc (Zn), copper (Cu), and magnesium (Mg) concentrations, copper/zinc ratio, and selenium (Se) status were studied in 44 vegetarians (22 males and 22 females) and their age- and sex-matched nonvegetarians in the Bratislava region (Slovakia). Vegetarians had statistically significant lower levels of plasma Zn a...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
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更新日期:1995-10-01 00:00:00
abstract::This work is a first attempt to determine the speciation of Cr in human plasma. With the aid of in vitro and in vivo 51Cr-labeled experiments, it was possible to develop the necessary biochemical techniques for the separation of the plasma proteins. Further work will use real samples, taking care to avoid contaminatio...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992700
更新日期:1990-07-01 00:00:00
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journal_title:Biological trace element research
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更新日期:2006-07-01 00:00:00
abstract::The distribution and chemical species of iodine in various subcellular fractions of human liver were studied by using epithermal neutron activation analysis combined with chemical and biochemical separation techniques, such as gradient centrifugation and gel chromatography. It was found that the total iodine content o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783916
更新日期:1999-07-01 00:00:00
abstract::The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 6 per group). Each group received 1 mL (intragastrically) of...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0293-8
更新日期:2015-09-01 00:00:00
abstract::Renal functions were damaged at the reabsorptive site by the injection of cadmium-metallothionein (Cd-MT) and its effect on discrimination of chemically similar elements was examined for the two alkaline-earth elements, calcium (Ca) and strontium (Sr). Tubular damage was induced in female Wistar rats, 7 wk old, body w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917418
更新日期:1989-10-01 00:00:00
abstract::Auditory brainstem electric response (ABR) and somatosensory evoked potential (SEP) of 21 subjects (41 ears) among villagers in a rare earth element (REE) area in Gan County, Jiangxi, China, were studied. No difference in ABR between the subjects from the REE area and the control group was noted. However, the conducti...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02803871
更新日期:1997-04-01 00:00:00
abstract::A cohort study on platers in Tokyo was carried out using the records of the Tokyo Health Insurance Society of Plating Industry. The type of work and chromium-exposure history of each member of this society was investigated by a questionnaire sent to the manager of each factory. The recovery rate of the questionnaire w...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783841
更新日期:1979-03-01 00:00:00
abstract::Breast milk is considered the best source of nutrition for all infants. However, exposure of newborns to toxic metals is of special interest due to their potential harmful effects. Thus, the primary aims of this study were to determine the concentration of toxic heavy metals including lead, mercury, cadmium, and bariu...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1355-5
更新日期:2019-01-01 00:00:00
abstract::The experiment was conducted to investigate the protective effects of different sources of maternal selenium (Se) on oxidative stressed chick embryo. A total of 270 Lingnan Yellow broiler breeders were randomly allocated into three treatments with five replicates for 18 birds each. Breeders were fed with basal diet (B...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-015-0541-y
更新日期:2016-07-01 00:00:00
abstract::The metabolic effects of dietary boron, magnesium, and molybdenum on mineral metabolism in the cholecalciferol-deficient chick, with emphasis on growth cartilage histology, were studied. One-day-old cockerel chicks were assigned to groups in a fully-crossed, three factor, 2 x 2 x 2 design. The basal diet was based on ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916650
更新日期:1989-11-01 00:00:00
abstract::A review of the activity of metal compounds in mammalian cell transformation assays has been completed. Results from these assays appear to correlate well with the known carcinogenic activity displayed by specific metal compounds in vivo. Studies of cell transformation in vitro may provide information pertaining to th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783248
更新日期:1982-06-01 00:00:00