Abstract:
:To obtain real-time dynamic changes of non-protein-bound copper in the blood, we have developed an online microdialysis sampling system coupled with a flow-injection graphite furnace-atomic absorption spectrometer (FI-GFAAS). The analytical performances of the online system such as linearity, limit of detection, precision, and spiked recoveries were validated. Before the in vivo experiments, the in vivo recovery was conducted. The levels of non-protein-bound Cu in the blood of living rabbits were evaluated before and after administering them with 5 mg/kg body weight of CuSO4 by the online microdialysis-FI-GFAAS system. The results showed that the average basal concentration of non-protein-bound Cu in the blood of living rabbits was 16.2 microg/L (n = 3). Furthermore, the levels of non-protein-bound Cu in the blood of living rabbits were observed after a long delay following intravenous injection of CuSO4. The non-protein-bound Cu reached the maximum value at 125 min after injection. Our present study might provide the in vivo, direct observation that different metals have their own binding characteristics with proteins when transported into the blood of living organisms.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Lin SJ,Lee CF,Tseng WC,Huang YL,Wu HLdoi
10.1385/BTER:111:1:255subject
Has Abstractpub_date
2006-07-01 00:00:00pages
255-63issue
1-3eissn
0163-4984issn
1559-0720pii
BTER:111:1:255journal_volume
111pub_type
杂志文章abstract::Chronic alcoholics frequently show associated malnutrition. Both ethanol and malnutrition exert profound changes on zinc and copper metabolism. In this study, we found higher hair zinc and copper values in 43 male alcoholics than in 39 controls. Hair copper was significantly related to the amount of ethanol consumed, ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:85:3:269
更新日期:2002-03-01 00:00:00
abstract::The biological function of selenium (Se) is mainly elicited through Se-containing proteins. Selenoprotein W (SelW), one member of the selenoprotein family, is essential for the normal function of the skeletal muscle system. To investigate the possible relationship of Se in the process of differentiation in chicken myo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9520-8
更新日期:2012-12-01 00:00:00
abstract::The seeds of Nelumbo nucifera (Lotus) have been used in the traditional system of medicine for various ailments including diabetes. The present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hypoglycemic propertie...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8614-4
更新日期:2010-12-01 00:00:00
abstract::The present research evaluated differential effects of sodium selenite and nano-Se on growth performance, tissue Se distribution, and glutathione peroxidase (GSH-Px) activity of avian broiler. Broilers were randomly segregated into 12 groups so that three replicates were available for each of the three treatments (T-1...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8264-y
更新日期:2009-05-01 00:00:00
abstract::Plasma concentrations of a zinc carrier peptide, namely thymulin, were measured according to a bioassay in young donors, healthy elderly, and patients with senile dementia of Alzheimer's type (SDAT). Thymulin is a hormone released by thymic epithelial cells and its biological activity on cells of immune system is depe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790147
更新日期:1996-01-01 00:00:00
abstract::Tibetan sheep have been observed with mineral deficiencies and marginal deficiencies in Qinghai-Tibetan Plateau. Adequate amounts of essential minerals are critical to maximize the productivity and health of livestock. The objectives of this study were to evaluate the effects of 6 months of mineral block supplementati...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-015-0593-z
更新日期:2016-08-01 00:00:00
abstract::Environmental metal exposure, as well as dietary metals, may adversely affect semen quality even as others play an essential role in normal spermatogenesis and fertility. Measures of seminal fluid metals have therefore been of high interest in the last several decades but have shown inconsistent results in correlation...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1527-3
更新日期:2019-07-01 00:00:00
abstract::In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8686-1
更新日期:2011-05-01 00:00:00
abstract::This study evaluated the effects of the different dietary zinc (Zn) levels on semen quality, on spermatozoa and seminal plasma antioxidant status, and on the seminal and blood plasma mineral status in mature male Cashmere goats during the breeding season. Twenty-eight mature male Liaoning Cashmere goats were divided i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01933-x
更新日期:2020-08-01 00:00:00
abstract::The effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using Akt2 and IRS1 gene expression methods in streptozotocin-induced diabetic rats. Fifty rats were randomly divided into five experimental groups: 1, non-diabetic control (NDC); 2, Mg2+-treated non-diabet...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1555-z
更新日期:2019-08-01 00:00:00
abstract::The present study was carried out to determine the effects of different sources of selenium (Se; sodium selenite [Na2SeO3] or selenomethionine [Se-Met]) supplementation on egg production, egg quality, levels of malondialdehyde (MDA), and Se in serum and egg yolk in heat-stressed Japanese quail (Coturnix coturnix japon...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8075-6
更新日期:2008-06-01 00:00:00
abstract::Strontium stimulates cartilage matrix formation in vitro. However, the mechanisms governing these effects have not yet been extensively reported. In this study, chondrocytes were isolated from rat articular cartilage by enzymatic digestion and cultured for 24-72 h with 1-5 mM strontium. We investigated the effects of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9640-9
更新日期:2013-06-01 00:00:00
abstract::Herein, we assess the antioxidant potential of core-shell yttrium oxide nanoparticles functionalized with ethylene glycol methacrylate phosphate (EGMP). The antioxidant properties of these nanoparticles were investigated in heat stressed models of 21 rats (heat stressed group, group B). Different samples of blood, ser...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02036-8
更新日期:2020-11-01 00:00:00
abstract::Adverse effects of mercury on female reproduction are reported; however, its effect on myogenic activity of uterus and mechanism thereof is obscure. Present study was undertaken to unravel the mechanistic pathways of mercuric chloride (HgCl2)-induced myometrial contraction in rats. Isometric tension in myometrial stri...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1379-x
更新日期:2019-02-01 00:00:00
abstract::In this study, a new method was developed for the pre-concentration of trace mercury from seafood samples prior to analysis by spectrophotometry. The method is based on the complexation between 2-hydrazinobenzothiazole (2-HBT)-modified copolymer(s) and Hg(II) in the presence of an ionic surfactant, cetyltrimethylammon...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1614-5
更新日期:2019-09-01 00:00:00
abstract::Prostate cancer is one of the most common cancers and the second cause of cancer-related deaths among men. Metals are recognized as chemical carcinogens where chronic exposures to such metals are implicated in the development of cancer, including prostate cancer. This in vitro study demonstrates the relative death sen...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0100-y
更新日期:2014-12-01 00:00:00
abstract::Animal feed has traditionally been supplemented with trace elements at dietary concentrations well above physiological needs. However, environmental concerns have led to calls for better adjustment of mineral supplementation to actual physiological needs and, in this context, consideration of breed-related differences...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1276-3
更新日期:2018-11-01 00:00:00
abstract::The characteristics of aluminum and chromium binding to apo-transferrin (apo-tf) have been investigated and compared. Both metal ions were taken up by human transferrin forming complexes with the maximum absorbances at 405 nm for chromium-transferrin (cr-tf) and 240 nm for aluminum-transferrin (Al-tf). In the presence...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784585
更新日期:1992-01-01 00:00:00
abstract::Auxiliary enzymes participate in β-oxidation of unsaturated fatty acids. The objective of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on Δ(3)Δ(2)-enoyl-CoA isomerase (ECI) in the liver and other tissues. Five groups of eight weanling rats each were fed...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9940-8
更新日期:2014-06-01 00:00:00
abstract::Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable Cu application. Cu-Z...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-0965-7
更新日期:2017-10-01 00:00:00
abstract::We investigated the effect of magnesium supplementation on zinc distribution in rats given excess calcium as carbonate. Rats were given a control diet (5 g/kg calcium and 0.5 g/kg magnesium), a high calcium diet (HC, 25 g/kg calcium and 0.5 g/kg magnesium) or the high calcium diet supplied with magnesium (HCM, 25 g/kg...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8166-z
更新日期:2008-11-01 00:00:00
abstract::Zinc (Zn) is essential for development, growth, and reproduction. The Mexican government subsidizes micronutrient-fortified milk for risk groups, with positive effect on the targeted groups' plasma Zn level, inferring a good absorption is achieved although it has not being measured. The aim of this study was to determ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0356-x
更新日期:2015-11-01 00:00:00
abstract::Recent findings showed that zinc might be linked to alanine aminotransferase (ALT) elevation. This analysis aimed to explore the association between serum zinc levels and ALT elevation in adults. Data on serum zinc and ALT levels from adults aged 20 years and older who participated in the 2011-2016 National Health and...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02318-1
更新日期:2020-07-31 00:00:00
abstract::The concentrations of cadmium, lead, selenium, and zinc in blood and seminal plasma were determined in 76 Singapore males. Except for zinc, the concentrations were generally higher in blood than in seminal plasma (cadmium, 1.31 micrograms/L vs 0.61 micrograms/L; lead, 82.6 micrograms/L vs 12.4 micrograms/L, and seleni...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916820
更新日期:1994-01-01 00:00:00
abstract::Aflatoxin B1 (AFB1) is the most toxic among the mycotoxins and causes detrimental health effects on the liver of human and animals. Selenium (Se) plays an important role in protection of various animal species against numerous notorious toxic agents. The present study is designed to explore the protective effects of S...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1623-4
更新日期:2019-10-01 00:00:00
abstract::Calsyntenin-2 (Clstn2) and calsyntenin-3 (Clstn3) are the members of the cadherin superfamily and function to regulate the postsynaptic activity. Both proteins are known to play an important role in memory and learning. This study was designed to test the hypothesis that exposure of mothers to Pb in drinking water may...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02241-5
更新日期:2020-06-16 00:00:00
abstract::The aim of this work is to verify whether there are statistically significant correlations between the concentrations of lead in blood, urine, and hair in children. The sample collected in 2007 consists of 163 children of both sexes from 11-14-year-olds, living in three municipalities of Sardinia (Italy). Inductively ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-8988-y
更新日期:2011-12-01 00:00:00
abstract::The knowledge about cesium metabolism and toxicity is sparse. Oral intake of cesium chloride has been widely promoted on the basis of the hypothesis referred to as "high pH cancer therapy", a complimentary alternative medicine method for cancer treatment. However, no properly confirmed tumor regression was reported so...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/s12011-009-8486-7
更新日期:2010-06-01 00:00:00
abstract::This study aimed to determine the relationship between the metabolic and endocrinological pathologies in polycystic ovary syndrome (PCOS) and the levels of arsenic, chromium, cadmium, lead, mercury, antimony, zinc, and copper to evaluate the relationship of these toxic metals with inflammatory/oxidative parameters. Th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02220-w
更新日期:2020-11-01 00:00:00
abstract::Trace elemental content was analysed in edible tissues of Mytilus galloprovincialis collected in five different sampling areas near the mouth of river Tagus estuary in Lisbon. The concentrations of essential elements (S, K, Ca, Fe, Cu, Zn, As, Br and Sr) were determined by energy-dispersive X-ray fluorescence (EDXRF) ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9974-y
更新日期:2014-06-01 00:00:00