Abstract：
:Plasma concentrations of a zinc carrier peptide, namely thymulin, were measured according to a bioassay in young donors, healthy elderly, and patients with senile dementia of Alzheimer's type (SDAT). Thymulin is a hormone released by thymic epithelial cells and its biological activity on cells of immune system is dependent on the presence of one molecule of zinc bound to the peptide. Plasma from different subjects were fractionated by gel filtration to yield protein-bound thymulin and free thymulin. The biological activity of the peptide was then assessed in the two different fractions. The activity of protein-bound thymulin was higher in young donors than in elderly or SDAT patients, being the lowest in SDAT. Addition of zinc ions to plasma fractions increased the thymulin activity of samples from elderly and SDAT patients to levels observed in young donors. Thymulin activity in free thymulin fractions was lower in the elderly than in the young and was practically undetectable in SDAT patients. The addition of zinc ions normalized the activity of thymulin in these fractions from both the elderly and SDAT patients. These findings confirm the presence of an altered zinc status in the elderly and suggest that an impaired zinc metabolism may be present in SDAT patients.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Licastro F,Davis LJ,Mocchegiani E,Fabris Ndoi
10.1007/BF02790147subject
Has Abstractpub_date
1996-01-01 00:00:00pages
55-62issue
1eissn
0163-4984issn
1559-0720journal_volume
51pub_type
杂志文章abstract：:Differences in mineral nutrient composition of soils have been considered to affect health and population characteristics of free-ranging animals, particularly herbivores. Contents of Ca, Mg, and K in hair of female fawn white-tailed deer (Odocoileus virginianus) were measured for eight consecutive years to determine ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783968
更新日期：1998-06-01 00:00:00
abstract：:The influence of several commercial albumin preparations on the ferroxidase activity of ceruloplasmin (ferroxidase I, ferrous: O2 oxidoreductase EC 1.16.3.1) at pH 6.0 was determined using ferric-transferrin formation. The ability of several albumin preparations to inhibit the ferroxidase activity of ceruloplasmin dif...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916628
更新日期：1983-04-01 00:00:00
abstract：:Plasma and erythrocyte lipid peroxidation levels of 20 patients with histopathologically confirmed testis cancer and 20 healthy control individuals were studied between November 1995 and June 1997. The group with testis cancer had a mean age of 24.8+/-8.2 yr and the control group's mean age was 28.3+/-6.9 yr. Stage di...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:73:2:181
更新日期：2000-02-01 00:00:00
abstract：:The objective of the study was analysis of hair trace elements content in children with goiter living in Aktubinsk region. Children with goiter and age- and sex-adjusted controls were involved in the current study. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. Thyroid vol...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-016-0711-6
更新日期：2016-12-01 00:00:00
abstract：:The aim of this work was to explore the effects of a low- and high-zinc diet and vitamin Aon the distribution of fatty acids in chylomicrons. Mongolian Gerbils were fed a basal diet (for 3 wk) containing 8 or 38 mg zinc/kg of feed (low-zinc group [termed LZ group] and saturated zinc group [termed SZ group], respective...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:112:2:145
更新日期：2006-08-01 00:00:00
abstract：:Zinc uptake regulator (Zur) is a negative transcriptional regulator of bacteria that belongs to the FUR superfamily of proteins and regulates zinc (Zn) homeostasis under extreme Zn conditions. The Zur protein of Bacillus anthracis (BaZur) was though characterized previously, but the residues of this transcriptional re...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02427-x
更新日期：2020-10-14 00:00:00
abstract：:The combination of excess mycotoxin exposure and selenium deficiency has been widely considered as a cause of Kashin-Beck disease (KBD). The present study aimed to investigate the expression profiles of selenium-related genes in human chondrocytes after exposure to T-2 toxin and deoxynivalenol (DON) and to preliminari...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1560-2
更新日期：2019-08-01 00:00:00
abstract：:Modifications in the enzyme activity of lysozyme, a protein implied in the defence barrier of the organism, can be a good biomarker of alterations in the immune system as a result of exposure to toxic metal, such as lead. The aim of this work was to evaluate the effect of a 200 ppm dose of lead on lysozyme activity in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9446-1
更新日期：2012-12-01 00:00:00
abstract：:Negative potassium balance during hypokinesia (decreased number of kilometers taken/day) is not based on the potassium shortage in the diet, but on the impossibility of the body to retain potassium. To assess this hypothesis, we study the effect of potassium loading on athletes during prolonged hypokinesia (HK). Studi...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/BF02783845
更新日期：1999-10-01 00:00:00
abstract：:Oxidative stress is involved in the pathogenesis of congestive heart failure (CHF). Some trace elements serve as antioxidant defenses. The purpose of this study was to analyze the effect of atrial fibrillation (AF) on zinc (Zn) and copper (Cu) levels in patients with advanced CHF. In this prospective study, serum Zn a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-8956-6
更新日期：2011-12-01 00:00:00
abstract：:Iodine, an essential micronutrient, is required to produce thyroid hormones. Iodine deficiency disorders (IDD) comprise a range of adverse maternal and fetal outcomes, with the most significant irreversible effect resulting from neurodevelopmental deficits in fetal brain caused by deficient iodine status during early ...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-018-1606-5
更新日期：2019-03-01 00:00:00
abstract：:Mitochondria from Trigonella foenum-graecum seedlings grown independently in the presence of either selenium (0.75 ppm) or mimosine (0.1 mM) exhibited respiration-stimulated energy-dependent uptake of Ca2+. Uptake studies were carried out independently at a series of Ca2+ concentrations at two different levels: (1) 1-...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:82:1-3:217
更新日期：2001-07-01 00:00:00
abstract：:The aim of the present study was to investigate the effect of selenium (Se) deficiency on the expression of the toll-like receptor (TLR) signal transduction pathway in the spleen of chickens and explore the relationship between the TLR4/TRIF/NF-κB signaling pathway and inflammatory spleen injury. A total of 200 one-da...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02173-0
更新日期：2021-02-01 00:00:00
abstract：:Three hundred and sixty healthy Ross × Ross 1-day-old broilers were used to study the effects of zinc glycine chelate (Zn-Gly) on oxidative stress, contents of trace elements, and intestinal morphology. All broilers were randomly assigned to six treatment groups, which replicates three times. Diets were as follows: (1...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8824-9
更新日期：2011-09-01 00:00:00
abstract：:Calcium, magnesium, and zinc balances were determined in eleven young adult college females (mean age, 24.9±2.35) during a 39-d metabolic study when the subjects were fed an adequate calorie and protein diet based on habitually consumed foods. Analysis showed that the dietary contribution of calcium, magnesium, and zi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917454
更新日期：1985-11-01 00:00:00
abstract：:Polaprezinc (zinc L-carnosine complex) is a tablet commonly prescribed for gastric ulcers in Japan. Recently, we reported the effects of polaprezinc on pressure ulcer healing at 4-week follow-up. We aimed to further evaluate the efficacy and safety of polaprezinc in 8-week treatment for chronic pressure ulcers. Patien...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-014-9943-5
更新日期：2014-06-01 00:00:00
abstract：:Despite the name, rare earth elements are relatively abundant in soil. Therefore, these elements might interact with biosphere during the history of life. In this study, we have examined the effect of rare earth ions on the growth of bacteria, fungi and soil nematode. All rare earth ions, except radioactive promethium...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0727-y
更新日期：2016-12-01 00:00:00
abstract：:Wistar male rats were exposed to nickel oxide (NiO) aerosols (mass median aerodynamic diameter, 1.2 μm). The average exposure concentration was controlled from low level (0.6 mg/m(3)) to high level (8.0 mg/m(3)) and total exposure time ranged from 140 to 216 h. Some rats were sacrificed just after the exposure, wherea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916542
更新日期：1985-02-01 00:00:00
abstract：:The present study was conducted to investigate whether the combined treatment with Se and Zn offers more beneficial effects than that provided by either of them alone in reversing Cd-induced oxidative stress in the kidney of rat. For this purpose, 30 adult male Wistar albino rats, equally divided into control and four...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8324-y
更新日期：2009-08-01 00:00:00
abstract：:Magnesium (Mg) concentrations in diets have been associated with performance and eggshell quality of laying hens, but the results have been inconclusive. In this experiment, the effects of increasing concentrations of dietary Mg on productive performance and eggshell quality of aged laying hens were evaluated. A total...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9537-z
更新日期：2013-01-01 00:00:00
abstract：:This study was designed to investigate the effects of chromium methionine (Cr-Met) on glucose metabolism, blood metabolites, meat lipid peroxidation, and tissue chromium (Cr) in Mahabadi goat kids. Thirty-two male kids (16.5 ± 2.8 kg BW, 4-5 months of age) were fed for 90 days in a completely randomized design with fo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0190-6
更新日期：2015-03-01 00:00:00
abstract：:Two trials were conducted in a 2 × 2 + 1 factorial arrangement based on a completely randomized design to evaluate the effects of different sources of selenium (Se) on performance, blood metabolites, and nutrient digestibility in male lambs on a barley-based diet. The first trial lasted for 70 days and consisted of 30...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9698-4
更新日期：2013-07-01 00:00:00
abstract：:The levels of iron, zinc, and copper in the tissues of the pregnant rat, on d 12, 19, and 21 after impregnation have been determined and compared with controls. Iron levels decreased considerably in late pregnancy as a result of increased fetal requirements, thus diminishing iron stores in rat tissues, but maintaining...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917464
更新日期：1985-09-01 00:00:00
abstract：:Previous studies revealed that Se was an important regulatory factor for glutathione peroxidase (GPx) genes. However, the relationship between Se concentrations and mRNA expression levels of GPxs were unclear in goats, especially the goats living in natural Se-enriched area. Thus, the aim of this study was to determin...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9830-5
更新日期：2013-12-01 00:00:00
abstract：:It has become evident over the last two decades that there is an intimate relationship between the trace elements and cancer. Some trace elements have been shown to be carcinogens, others appear to provide protection against cancer. Profound changes in trace element concentrations and distribution occur in patients wi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783817
更新日期：1979-08-01 00:00:00
abstract：:This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO4) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO4 strongly inhibited the replic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01728-0
更新日期：2020-02-01 00:00:00
abstract：:For this study, we investigate more deeply the effect calcium (Ca) develops on the mechanism underlying fluoride-triggered osteocyte apoptosis. We detected the morphology of osteocytes by HE staining, mitochondrial microstructure by using the transmission electron microscope, and the biochemical indexes related to bon...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02305-6
更新日期：2020-07-25 00:00:00
abstract：:The present study was conducted to investigate the effects of chromium histidinate (CrHis) against experimentally induced type II diabetes and on chromium (Cr), zinc (Zn), selenium (Se), manganese (Mn), iron (Fe), and copper (Cu) in serum, liver, and kidney of diabetic rats. The male Wistar rats (n = 60, 8 weeks old) ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8351-8
更新日期：2009-11-01 00:00:00
abstract：:Long-term diabetes mellitus can induce osteopenia and osteoporosis, an increase in the incidence of low-stress fractures, and/or delayed fracture healing. Strontium ranelate (SrR) is a dual-action anti-osteoporotic agent whose use in individuals with diabetic osteopathy has not been adequately evaluated. In this study...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1322-1
更新日期：2018-12-01 00:00:00
abstract：:Significant disorders of liver metabolic pathways enzymes after high-cholesterol diet could give information on liver steatosis development. This process could probably also be inhibited by some compounds, as examined in rabbits. Forty-two male rabbits were served a high-cholesterol diet (2 g%) (0.67 g/kg b.m./24 h) w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0070-4
更新日期：2007-01-01 00:00:00
