Abstract：
:Using the dimethylbenz(a)anthracene-induced mammary tumor model in rats, our studies indicated that there was a dose-response relationship between dietary selenium supplementation and the inhibition of mammary carcinogenesis. The degree of inhibition was proportional to the level of dietary selenium up to 5 ppm, at which point toxicity in the form of a reduction in weight gain was evident. Moreover, it was observed that the chemopreventive efficacy of selenium was influenced by the dose of carcinogen as well as the fat intake of the animals. By supplementing selenium for defined periods of time, we concluded that selenium inhibited both the initiation and the promotion phases of chemical carcinogenesis, and that a continuous intake of selenium was necessary to achieve maximal suppression of tumor growth. In an attempt to improve the efficacy of lower levels of selenium, we conducted another series of experiments in which selenium and vitamin E were tested in combination. Results showed that although vitamin E alone had no prophylactic effect against tumorigenesis, it potentiated the ability of selenium to inhibit the development of mammary tumors. Further investigation suggested that the anticarcinogenic action of selenium could not be explained by its antioxidant function in lipid peroxidation. On the other hand, vitamin E might be able to provide a more favorable climate against oxidant stress to facilitate selenium in exerting its inhibitory effect through some other mechanisms.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Ip Cdoi
10.1007/BF02987217subject
Has Abstractpub_date
1983-08-01 00:00:00pages
317-30issue
4-5eissn
0163-4984issn
1559-0720journal_volume
5pub_type
杂志文章abstract：:Selenium and mercuric chloride (MC) interactions regarding effects on cell growth and cell death have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) and with MC (35 or 50 microM). The 35-microM MC treatments resulted...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:92:2:105
更新日期：2003-05-01 00:00:00
abstract：:The main source of environmental arsenic exposure in most countries of the world is drinking water in which inorganic forms of arsenic predominate. The present study was aimed to test the impact of two different compounds of inorganic arsenic in histomorphometric and enzymatic parameters in the testes by oral expositi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0523-0
更新日期：2016-06-01 00:00:00
abstract：:Previous studies revealed that Se was an important regulatory factor for glutathione peroxidase (GPx) genes. However, the relationship between Se concentrations and mRNA expression levels of GPxs were unclear in goats, especially the goats living in natural Se-enriched area. Thus, the aim of this study was to determin...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9830-5
更新日期：2013-12-01 00:00:00
abstract：:It was determined if the sensitivity in macular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6-8-d-old or 3-4-wk-old macular mutant mouse to copper-induced toxicity was not affected by sex. However, 8-9-wk-old mutant females were more sensitive to copper-induced toxicity than ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783183
更新日期：1993-11-01 00:00:00
abstract：:The study was undertaken to investigate the influence of alpha-tocopherol on zinc, copper, iron, calcium, magnesium, and potassium concentrations in serum of rats with bleomycin-induced pulmonary fibrosis. Fourteen Wistar albino rats were randomly divided into two groups of seven animals each. The first group was trea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:114:1:175
更新日期：2006-01-01 00:00:00
abstract：:The aim of this work was to explore the effects of a low- and high-zinc diet and vitamin Aon the distribution of fatty acids in chylomicrons. Mongolian Gerbils were fed a basal diet (for 3 wk) containing 8 or 38 mg zinc/kg of feed (low-zinc group [termed LZ group] and saturated zinc group [termed SZ group], respective...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:112:2:145
更新日期：2006-08-01 00:00:00
abstract：:The relationship between Ni-induced hepatic lipid peroxidation (LPO) and the concentrations of Ni and trace elements was investigated in male ICR mice. The protective effects of antioxidants were also examined. Hepatic LPO and the concentrations of Ni, Fe, Cu, and Zn in the liver were enhanced after an ip injection of...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784030
更新日期：1998-02-01 00:00:00
abstract：:The effects of dietary sodium selenite and vitamin E on the microvascular permeability of rat organs such as heart, brain, kidney, liver and eye were investigated by using the Evans blue leakage method. Combined deficiency of selenium and vitamin E caused an increase in the permeability of the heart and eye with respe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783332
更新日期：1998-07-01 00:00:00
abstract：:The association between serum copper and zinc concentrations and age, sex, and other risk factors of cardiovascular disease in randomly selected adult volunteers aged 19-59 were investigated. There was a positive relationship between copper and age in both sexes, but zinc was negatively correlated with age in males on...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02950795
更新日期：1994-03-01 00:00:00
abstract：:Infant complementary foods are readily available in the UK markets and nowadays, weaning mothers prefer feeding their babies with these products due to modern lifestyles. However, there is a dearth of research with respect to the health risk assessment of trace essential and potentially toxic elements in these product...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02285-7
更新日期：2020-07-16 00:00:00
abstract：:X-ray Fluorescence (XRF) Analysis and Atomic Absorption Spectrophotometry (AAS) have been used in assessing heavy metal pollution from some gold mines in Ghana. The presence and levels of heavy metals in gold ore, gold tailings, inland waters, and river sediments have been determined. Using these techniques, the heavy...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992682
更新日期：1990-07-01 00:00:00
abstract：:As a nutritionally essential trace element, selenium (Se) is crucial for fish growth. However, the underlying mechanisms remain unclear. Fish somatic growth relies on the white muscle growth. This study aimed to explore the effects and underlying mechanisms of Se on fish white muscle growth using a juvenile rainbow tr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02282-w
更新日期：2020-07-14 00:00:00
abstract：:Numerous experiments in vitro and in vivo have shown that an appropriate increase intake of silicon can facilitate the synthesis of collagen and its stabilization and promote the differentiation and mineralization of osteoblasts. In this study, we examined whether ortho-silicic acid restrains the differentiation of os...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02286-6
更新日期：2020-07-16 00:00:00
abstract：:Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is the most common human enzymopathy in the world. Trace elements are important for normal hematopoiesis and can play a role in acute hemolytic anemia induced by G-6-PD deficiency. For this purpose, we studied two groups consisting of 10 male children who are G-6-P...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:99:1-3:041
更新日期：2004-07-01 00:00:00
abstract：:Twenty-seven infants with classical phenylketonuria were evaluated longitudinally for 6 mo while ingesting Phenex-1 Amino Acid Modified Medical Food With Iron as their primary protein source. Intake of selected nutrients and biochemical indices of trace and ultratrace mineral status and plasma retinol and alpha-tocoph...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/BF02784277
更新日期：1999-01-01 00:00:00
abstract：:The objective of the study was to evaluate the maximum tolerance limit of amino acid copper complex (Cu-Lys-Glu) for laying hens by measuring their laying performance, hematological and serum biochemical parameters, organ index, and histopathology. A total of 450 18-week-old Beijing White layers were randomly allocate...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02406-2
更新日期：2020-10-12 00:00:00
abstract：:Selenium deficiency is known to cause cardiovascular diseases. However, the role of Se deficiency in causing oxidative damage and inflammation injury to the aorta vessels of chickens is not well known. In the present study, 180 1-day-old chickens were randomly divided into two groups, a low-Se group (L group) and a co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0676-5
更新日期：2016-10-01 00:00:00
abstract：:Given the conflicting results about the positive effects of magnesium and L-carnitine and as there is no report concerning concurrent supplementation of magnesium and L-carnitine on migraine prophylaxis, the effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation on migraine indicators ...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-012-9487-5
更新日期：2012-12-01 00:00:00
abstract：:Lung cancer is seriously threatening human health and exposure to trace metals is the most important aetiology for lung cancer. Selected essential/toxic metals (Ca, Mg, Na, K, Fe, Zn, Cu, Sr, Li, Co, Mn, Ni, Cr, Cd and Pb) are measured in the scalp hair and nails of lung cancer patients and controls by atomic absorpti...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9942-6
更新日期：2014-06-01 00:00:00
abstract：:Exposure of cells to ionizing radiation leads to the formation of reactive oxygen species (ROS) that are associated with radiation-induced cytotoxicity. Because of the serious damaging potential of ROS, cells depend on the elaboration of the antioxidant defense system (AODS), both enzymatic and nonenzymatic oxidant de...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:86:1:55
更新日期：2002-04-01 00:00:00
abstract：:In this article, we report the results of a case control study carried out on 290 Turkish pregnant women at 5-24 wk of gestation to determine their zinc, folic acid, and vitamin B12 levels in relation to their nutritional and socioeconomic status. The women were divided into two groups (n=145 each), depending on the s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:109:2:105
更新日期：2006-02-01 00:00:00
abstract：:In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8686-1
更新日期：2011-05-01 00:00:00
abstract：:Rare earth elements can promote photosynthesis, but their mechanisms are still poorly understood under magnesium deficiency. The present study was designed to determine the role of cerium in magnesium-deficient maize plants. Maize was cultivated in Hoagland's solution added with cerium with and without adequate quanti...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8769-z
更新日期：2011-09-01 00:00:00
abstract：:The control of metallothionein (MT) synthesis was investigated in freshly prepared rat hepatocytes in experiments of short-term duration. Viability and metabolic function were maintained in incubations of 6-h duration. MT synthesis was measurable in hepatocytes from fed rats at Zn concentrations down to 1 microM. Zn a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783778
更新日期：1993-01-01 00:00:00
abstract：:Strontium stimulates cartilage matrix formation in vitro. However, the mechanisms governing these effects have not yet been extensively reported. In this study, chondrocytes were isolated from rat articular cartilage by enzymatic digestion and cultured for 24-72 h with 1-5 mM strontium. We investigated the effects of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9640-9
更新日期：2013-06-01 00:00:00
abstract：:The accumulation of cadmium, its affinity for metallothioneins (MTs), and its relation to copper, zinc, and selenium were investigated in the experimental mudpuppy Necturus maculosus and the common toad Bufo bufo captured in nature. Specimens of N. maculosus were exposed to waterborne Cd (85 μg/L) for up to 40 days. E...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9461-2
更新日期：2012-12-01 00:00:00
abstract：:The selenium concentrations were determined in liver, kidney, skeletal muscle, heart, brain, prostate, testis, bile, lung, and spleen of German traffic accident victims. In addition, the nitrogen and phosphorus contents were determined in the same organs and tissues. On a per-weight unit basis, the highest selenium co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990125
更新日期：1988-01-01 00:00:00
abstract：:The phosphorus NMR profile of normal and vanadium-treated chick muscle was obtained in vivo. The data show that the differentiation of breast and thigh muscles in terms of pH, lipid related metabolites, and bioenergetic parameters can be readily followed. Although the vanadium-treated chicks showed substantial retarda...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990427
更新日期：1991-11-01 00:00:00
abstract：:Aflatoxin B1 (AFB1) is a mycotoxin that causes cytotoxicity through oxidative damage to its target organs. The liver is the first target of AFB1 damage. The aim of this study was to evaluate the protective effect of selenium on AFB1-induced hepatic mitochondrial damage in ducklings using molecular biological and histo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0189-z
更新日期：2015-02-01 00:00:00
abstract：:Previous studies showed the attenuation of both morphine-dependence and morphine-place preference by zinc. Conditioned place preference and aversion are experimental models frequently used to test the reward-stimulating, respectively the aversive effects induced by different stimuli or substances. Addictive substances...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-0995-1
更新日期：2017-11-01 00:00:00
