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Selenium protection against mercury-induced apoptosis and growth inhibition in cultured K-562 cells.

Abstract：

:Selenium and mercuric chloride (MC) interactions regarding effects on cell growth and cell death have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) and with MC (35 or 50 microM). The 35-microM MC treatments resulted in a clear inhibition of cell growth with no obvious difference between mercury-treated and mercury-selenium-treated cells. Furthermore, the apoptotic frequency was similar at all observations for all selenium treatments with 35 microM MC. In the simultaneously treated selenite and 50- microM MC combinations, a selenite-dependent protection was shown both by increased cell growth and by lower apoptotic frequency at 48 and 96 h of exposure. Both treatments with selenomethionine showed protection observed as an increased cell growth at 48 and 96 h and as decreased apoptotic frequency at 96 h of exposure.

journal_name

Biol Trace Elem Res

journal_title

Biological trace element research

authors

Frisk P,Wester K,Yaqob A,Lindh U

doi

10.1385/BTER:92:2:105

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

105-14

issue

2

eissn

0163-4984

issn

1559-0720

pii

BTER-92-2-105

journal_volume

92

pub_type

杂志文章

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