Abstract:
:Zinc has been reported to enhance the response to interferon (IFN) or PEG-IFN plus ribavirin therapy, improve liver function, and ameliorate hematologic side effects in patients with chronic hepatitis C. However, the role of zinc supplementation during IFN therapy in chronic hepatitis B infection (CHB) remains unclear. We therefore aimed to report the results of zinc and IFN-alpha-2a therapy in children with CHB. Twenty-two naive, HBeAg-positive children (mean age 10.4 ± 4.4 years) received IFN-α2a (9 MU/m(2) sc) for 6 months plus peroral zinc (7.5 mg/day for <10 years and 10 mg/day for >10 years) for 12 months. Serum zinc, alanine aminotransferase (ALT), complete blood count, hepatitis B virus DNA (HBV DNA), and serological markers were measured. Histological (HR) and sustained response (SR) were evaluated at 6 months after completion of therapy. Normalization of ALT, HBeAg seroconversion, and HBV DNA < 10,000 copies/ml were considered as SR. HR was defined as decrease in Knodell histological activity index (HAI) score by at least 2 points compared to baseline. End of therapy ALT level and log HBV DNA were significantly lower than pretherapy levels (p = 0.001 and p = 0.001, respectively), while zinc level was not different. Portal inflammation score significantly decreased after therapy (p = 0.043), however, total HAI and other HAI components were not different. SR and HR were 25% and 52.9%. In conclusion as a first study investigating the effect of zinc and IFN combination therapy in children with CHB, SR and HR rates were not better than previously reported monotherapy or combination therapies.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Kuloğlu Z,Kırbaş G,Erden E,Kansu Adoi
10.1007/s12011-011-8971-7subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1302-9issue
3eissn
0163-4984issn
1559-0720journal_volume
143pub_type
杂志文章abstract::The purpose of this 42-day study was to examine the effect of dietary vanadium on the ileac T cells and contents of cytokines including interleukin-2 (IL-2), interleukin-6 (IL-6), and interferon-gamma (IFN-γ) in broilers by flow cytometry and enzyme-linked immunosorbent assay. A total of 420 one-day-old avian broilers...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9274-8
更新日期:2012-06-01 00:00:00
abstract::Selenoprotein K (SelK), a member of selenoprotein family, is identified as a single endoplasmic reticulum (ER) transmembrane protein. Although over-expression of SelK inhibits adherence and migration of human gastric cancer BGC-823 cells, the effects of SelK in human choriocarcinoma (CCA) are not well understood. In t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1155-3
更新日期:2018-07-01 00:00:00
abstract::The aim of this study was to investigate the relationships between the bronchopneumonia and mean concentrations of those trace elements in bronchoalveolar lavage fluid (BALF). Twenty-nine dogs were included this study (17 healthy dogs and 12 dogs with respiratory disease). Each BALF sample had been obtained during bro...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8149-0
更新日期:2008-07-01 00:00:00
abstract::Calcium, phytic acid, polyphenols and fiber are major inhibitors of iron absorption and they could be found in excess in some diets, thereby altering or modifying the iron nutrition status. The purpose of this study is to evaluate the effect of calcium, tannic acid, phytic acid, and pectin over iron uptake, using an i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9911-0
更新日期:2014-04-01 00:00:00
abstract::Footrot (FR) is a common, contagious bacterial disease of sheep that results in lameness and significant economic losses for producers. We previously reported that sheep affected with FR have lower whole-blood (WB) selenium (Se) concentrations and that Se supplementation in conjunction with routine control practices a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9716-6
更新日期:2013-07-01 00:00:00
abstract::The metabolic effects of dietary boron, magnesium, and molybdenum on mineral metabolism in the cholecalciferol-deficient chick, with emphasis on growth cartilage histology, were studied. One-day-old cockerel chicks were assigned to groups in a fully-crossed, three factor, 2 x 2 x 2 design. The basal diet was based on ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02916650
更新日期:1989-11-01 00:00:00
abstract::Selenoproteins and selenium (Se) play important roles in the immune system. Selenoprotein expression in the immune system of mammals is sensitive to dietary Se levels; however, little is known about the expression of selenoproteins and their immune functions in the chicken thymus. We assessed selenoprotein gene expres...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0282-y
更新日期:2015-09-01 00:00:00
abstract::The authors present a simple and rapid method for assaying ultrafilterable copper (Cu UF) and albumin-bound copper (Cu ALB). It is based on the ultrafiltration of serum in the presence of ethylenediaminetetraacetic acid (EDTA), used to prevent adsorption on the membranes. EDTA at 0.4 g/L has no effect on the equilibri...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917499
更新日期:1988-12-01 00:00:00
abstract::The selenium levels and the glutathione peroxidase activity GSH-PX of whole blood and of erythrocytes, respectively, were determined in 139 normal Danes and related to sex and smoking habits. No differences were found in relation to sex apart from a higher GSH-PX activity of females when assayed with tertiary butyl hy...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/BF02990131
更新日期:1988-01-01 00:00:00
abstract::Silicon (Si) is important for the growth and development of bone and connective tissues. Several studies have reported that Si supplementation improved bone mineral density (BMD) in female ovarectomized rats. However, few studies have investigated the effects of Si supplementation on bone status and bone metabolism in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9936-4
更新日期:2014-05-01 00:00:00
abstract::A dose-response experiment was conducted to find the sensitive and consistent biomarker for the estimation of dietary manganese (Mn) requirement and establish the optimal Mn level for broilers fed a practical corn-soybean meal diet from 1 to 21 days of age post-hatching. A total of 480 1-day-old Arbor Acres male chick...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8931-7
更新日期:2011-11-01 00:00:00
abstract::Preoperative diagnosis of papillary thyroid carcinoma (PTC) comprises numerous diagnostic procedures which are mostly applicable in tertiary institutions. Normal thyroid function depends on the presence of many trace elements and copper (Cu) and zinc (Zn) are some of those. The study is based on retrospective review o...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-014-0071-z
更新日期:2014-09-01 00:00:00
abstract::Interaction between toxic and essential elements is of particular interest, because the deficiency of essential element can dramatically increase the absorption rate of toxic metals inside the body. This study was conducted to evaluate the possible correlation of lead (Pb) with calcium (Ca), iron (Fe), and zinc (Zn) i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1141-9
更新日期:2018-06-01 00:00:00
abstract::It was determined if the sensitivity in macular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6-8-d-old or 3-4-wk-old macular mutant mouse to copper-induced toxicity was not affected by sex. However, 8-9-wk-old mutant females were more sensitive to copper-induced toxicity than ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783183
更新日期:1993-11-01 00:00:00
abstract::China has eliminated iodine deficiency disorders since 2011 via the implementation of universal salt iodisation. Following this, a new revised salt iodisation policy was introduced to reduce iodine content in table salt. Since maternal iodine deficiency can lead to cognitive impairment and cretinism in infants, the ai...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02135-6
更新日期:2021-01-01 00:00:00
abstract::Adaptive alterations in glutathione (GSH) metabolism were studied during oxidative stress induced by selenium (Se) deficiency in germinating seedlings of Trigonella foenum-graecum grown for 72 h and the response to supplementation individually of Se or mimosine was explored. Growth enhancement with improved mitochondr...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783830
更新日期:1999-12-01 00:00:00
abstract::The use of phosphate fertilizers is essential in agriculture, because they supply farmland with nutrients for growing plants. However, heavy metals might be included as impurities in natural materials and minerals, so heavy metals can also be present in phosphate fertilizers or other chemical fertilizers. The aim of t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9161-3
更新日期:2012-01-01 00:00:00
abstract::Kashin-Beck disease (KBD) is an endemic, degenerative osteoarthropathy, and particularly seen in China. A deficiency of selenium and iodine is implicated as the main etiological factor for KBD. This meta-analysis aimed to evaluate the differences in the selenium and iodine levels between patients with KBD and healthy ...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析
doi:10.1007/s12011-015-0463-8
更新日期:2016-03-01 00:00:00
abstract::The study was undertaken to investigate the influence of alpha-tocopherol on zinc, copper, iron, calcium, magnesium, and potassium concentrations in serum of rats with bleomycin-induced pulmonary fibrosis. Fourteen Wistar albino rats were randomly divided into two groups of seven animals each. The first group was trea...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:114:1:175
更新日期:2006-01-01 00:00:00
abstract::Lanthanum cations (La 3+) are well known for their inhibitory actions on calcium channels. Prenatal lanthanum exposure may affect the development of embryo and alter the capacity for learning and memory in adults, and the one-trial passive avoidance learning paradigm with day-old chicks is an excellent model to study ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8225-5
更新日期:2009-01-01 00:00:00
abstract::The present study was conducted to investigate whether the combined treatment with Se and Zn offers more beneficial effects than that provided by either of them alone in reversing Cd-induced oxidative stress in the kidney of rat. For this purpose, 30 adult male Wistar albino rats, equally divided into control and four...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8324-y
更新日期:2009-08-01 00:00:00
abstract::This in vitro study was designed to assess the impact of divalent (Fe(2+)) or trivalent (Fe(3+)) iron on the activity and oxidative balance of bovine spermatozoa at specific time intervals (0, 2, 8, 16, and 24 h) during an in vitro culture. Forty-five semen samples were collected from adult breeding bulls and diluted ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0288-5
更新日期:2015-09-01 00:00:00
abstract::Retraction to: Biol Trace Elem Res 144(1–3):1120–1132, DOI 10.1007/s12011-011-9149-z. Article has been retracted due to duplicate publication. ...
journal_title:Biological trace element research
pub_type: 撤回出版物
doi:10.1007/s12011-012-9550-2
更新日期:2013-01-01 00:00:00
abstract::Plasma chromium concentrations have been determined for 150 patients. These were subjected to coronary artery cineangiography and thereby divided into three groups: group CAD (those with coronary artery disease), group HD (those with heart disease, but no CAD) and group N (those with no CAD and no HD). Weighted, avera...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02989260
更新日期:1984-10-01 00:00:00
abstract::We investigated the effect of magnesium supplementation on zinc distribution in rats given excess calcium as carbonate. Rats were given a control diet (5 g/kg calcium and 0.5 g/kg magnesium), a high calcium diet (HC, 25 g/kg calcium and 0.5 g/kg magnesium) or the high calcium diet supplied with magnesium (HCM, 25 g/kg...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8166-z
更新日期:2008-11-01 00:00:00
abstract::The knowledge about cesium metabolism and toxicity is sparse. Oral intake of cesium chloride has been widely promoted on the basis of the hypothesis referred to as "high pH cancer therapy", a complimentary alternative medicine method for cancer treatment. However, no properly confirmed tumor regression was reported so...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/s12011-009-8486-7
更新日期:2010-06-01 00:00:00
abstract::Three kinds of plant leaves, Chinese white aspen, arborvitae, and pine needles, have been sampled from the Yanshan Oil refinery complex, the Capital Iron and Steel Factory, and Badachu, a control area in Beijing, as biomonitors for air-pollution studies. Each sample was divided into two parts, washed, and unwashed. Th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784212
更新日期:1999-01-01 00:00:00
abstract::The influence of dietary supplementation with thiamine on lead (Pb) contents in blood and tissues, blood δ-aminolevulinic acid dehydratase (δ-ALAD) activity, and urinary excretion of δ-aminolevulinic acid (δ-ALA) was evaluated in male Sprague-Dawley rats. Groups of randomly selected animals were given a thiamine-defic...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795566
更新日期:1986-08-01 00:00:00
abstract::Recently, several attempts have been made to use the phytopharmaceuticals from plant extracts as reducing, capping and stabilizing agents for the biomimetic synthesis of various metal nanoparticles conjugated to the phytopharmaceuticals. These biogenic metal nanoparticles are non-toxic and can be used as contrast agen...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1287-0
更新日期:2018-11-01 00:00:00
abstract::Lithium is an integral drug used in the management of acute mania, unipolar and bipolar depression, and prophylaxis of bipolar disorders. Thyroid abnormalities have been associated with treatment with lithium. Zinc is an essential trace element that plays a role in several biological activities. Therefore, the present...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02356-9
更新日期:2020-08-26 00:00:00